Results 111 to 120 of about 2,345,864 (352)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Integrability and holographic aspects of six-dimensional N = 1 , 0 $$ \mathcal{N}=\left(1,\ 0\right) $$ superconformal field theories

Journal of High Energy Physics, 2019
In the framework of six-dimensional conformal field theories with N = 1 , 0 $$ \mathcal{N}=\left(1,\ 0\right) $$ supersymmetry we develop the map between the holographic description, the field theoretical description and the associated Hanany-Witten set ...
Kostas Filippas, Carlos Núñez, Jeroen van Gorsel   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The Fractional Carleson Measures on the Unit Ball of ℝn+1

Journal of Function Spaces and Applications, 2013
We construct a quantity in terms of Lp integral of the Jacobian of a conformal self-map on the unit ball of ℝn+1. Then, we characterize the fractional Carleson measures on the unit ball by the quantity.
Dongfang Wang, Bolin Ma
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

General f-harmonic morphisms

Arab Journal of Mathematical Sciences, 2016
In this paper, we prove that a map between Riemannian manifolds is an f-harmonic morphism in a general sense if and only if it is horizontally weakly conformal, satisfying some conditions, and we investigate the properties of f-harmonic morphism in a ...
Nour Elhouda Djaa, Ahmed Mohamed Cherif
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Virtual Mass of Any Shape of Body by using General Mapping Function

MATEC Web of Conferences, 2017
When an object is moving in acceleration with fluid interaction from surrounding, it possesses virtual mass (added mass) in which the total mass of object is higher than the original mass.
Arai Norio
doaj   +1 more source

Optimization Of Conformal Cartographic Projections For The Slovak Republic According To Chebyshev’s Theorem

Slovak Journal of Civil Engineering, 2015
Disadvantages of the currently used Křovák’s map projection in the Slovak Republic, such as large scale distortion, became evident after the division of Czechoslovakia.
Szatmári Daniel
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source