Results 171 to 180 of about 2,345,864 (352)

FOXP3 Polymorphism and Upregulation of the CXCL12‐CXCR4‐SNAIL Axis with High Infiltration of M2TAM by STAT3/NFKB Pathways Influence the Survival of Cervical Cancer Patients

open access: yesAdvanced Biology, EarlyView.
This study highlights how cervical carcinoma progression is shaped by immune–tumor interactions within the TME. M2‐TAM infiltration, regulated through STAT3/NF‐κB and linked to CXCL12–CXCR4, promotes immune suppression, angiogenesis, and poor survival.
George A. Lira   +11 more
wiley   +1 more source

Quantum chaos in Liouville CFT

open access: yesJournal of High Energy Physics
Fast scrambling is a distinctive feature of quantum gravity, which by means of holography is closely tied to the behaviour of large-c conformal field theories.
Julian Sonner, Benjamin Strittmatter
doaj   +1 more source

Engineering the Link: From Genome Interaction Maps to Functional Insight

open access: yesAdvanced Biology, EarlyView.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen   +5 more
wiley   +1 more source

Laser Metal Deposited Ti4822 Hollow Pipe: Experimental and Computational Modelling Study

open access: yesAdvanced Engineering Materials, EarlyView.
Laser metal deposition (LMD) of a crack‐free built Ti4822 alloys is challenging. This article reports outstanding characteristics of a hollow pipe that is built with LMD technology when a predicted, nontransformation substrate temperature of 800 °C is used.
Sadiq A. Raji   +5 more
wiley   +1 more source

Additive Manufacturing of Hot Work Tool Steel by Laser Powder Bed Fusion Utilizing Powder Mixtures Including Grinding Chips: Assessing Chemical Homogeneity and Achievable Hardness

open access: yesAdvanced Engineering Materials, EarlyView.
Grinding chips of high‐alloyed steel are prepared to be admixed to a starting powder mixture for laser powder bed fusion. A three‐stage preparation is performed, including washing in acetone, magnetic separation, and ball milling. The addition of 30% of grinding chips to the powder mixture allows the fabrication of dense samples.
Felix Großwendt   +4 more
wiley   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

open access: yesAdvanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice   +2 more
wiley   +1 more source

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