Results 51 to 60 of about 93,031 (274)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Higher derivative invariants in four dimensional 𝒩 = 3 Poincaré supergravity

Journal of High Energy Physics, 2023
In this paper we use the superconformal approach to derive the higher derivative action for 𝒩 = 3 Poincaré supergravity in four space-time dimensions. We first study the coupling of 𝒩 = 3 vector multiplets to conformal supergravity. Thereafter we combine
Subramanya Hegde, Madhu Mishra, Debangshu Mukherjee, Bindusar Sahoo   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Correlation functions of sourced gravitational waves in inflationary scalar vector models. A symmetry based approach

Journal of High Energy Physics, 2019
We use conformal symmetry to constrain the shape of inflationary correlators in the presence of long-lived vector field perturbations. Applying conformal Ward identities, we derive general expressions, up to amplitudes and normalization factors, for the ...
Juan P. Beltrán Almeida, Josué Motoa-Manzano, César A. Valenzuela-Toledo   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Closed Conformal Vector Fields in Gradient Einstein Solitons

Axioms
We investigate gradient Einstein solitons admitting closed conformal vector fields. Under constant scalar curvature, we establish rigidity results showing that complete solitons with non-parallel closed conformal vector fields are isometric to Euclidean ...
Norah Alshehri, Fatin Nabila Abd Latiff, Mukarram Ali, Akram Ali   +3 more
doaj   +1 more source

Scalar and vector gauges unification in de Sitter ambient space formalism

Nuclear Physics B, 2022
We consider the massless minimally coupled scalar field in the de Sitter ambient space formalism as a gauge potential or connection field. We construct the scalar gauge theory by helping an arbitrary constant five-vector field Bα analogous to the ...
M.V. Takook
doaj   +1 more source

Graviton Vertices and the Mapping of Anomalous Correlators to Momentum Space for a General Conformal Field Theory

, 2012
We investigate the mapping of conformal correlators and of their anomalies from configuration to momentum space for general dimensions, focusing on the anomalous correlators $TOO$, $TVV$ - involving the energy-momentum tensor $(T)$ with a vector $(V)$ or
A Bzowski, A Cappelli, AI Davydychev, AM Polyakov, C Corianò, Claudio Corianò, D Kazakov, DZ Freedman, E Fradkin, E Mottola, E Mottola, Emil Mottola, F Bastianelli, F Bastianelli, G Degrassi, GV Dunne, H Osborn, I Antoniadis, J Erdmenger, JM Maldacena, L Bonora, Luigi Delle Rose, M Duff, M Duff, M Giannotti, Mirko Serino, PO Mazur, PR Anderson, R Armillis, R Armillis, R Bertlmann, R Riegert, S Raju, SR Coleman, YS Stanev, YS Stanev   +35 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Analysis of m-Modified Conformal Vector Fields on the Tangent Bundle With Synectic Lift Metrics

International Journal of Mathematics and Mathematical Sciences
In this study, we introduce the notion of an m-modified conformal vector field, which represents a natural generalization of the classical conformal vector field concept. This extension allows for a broader class of vector fields that conform to modified
Lokman Bilen, Erkan Karakas, Cagri Karaman, Aydin Gezer, Yanlin Li   +4 more
doaj   +1 more source