Antibody Fragments Defining Biologically Relevant Conformations of Target Proteins
Antibodies, 2014 Antibody fragments have long been used as chaperones in crystallography, but have more recently been applied to the definition of biologically relevant conformations among the dynamic ensemble of target protein conformational sampling. This review charts
Alastair D. G. Lawson
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Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics [PDF]
, 2014 Dinuclear metal complexes have emerged as a promising class of biologically active compounds which possess unique anticancer activity. Here, we describe a novel series of arene-linked dinuclear organometallic Ru(II) complexes, where the relative ...
Dyson, Paul J. +3 more
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Investigation of the Ergopeptide Epimerization Process
Computation, 2014 Ergopeptides, like ergocornine and a-ergocryptine, exist in an S- and in an R-configuration. Kinetic experiments imply that certain configurations are preferred depending on the solvent. The experimental methods are explained in this article. Furthermore,
Karsten Andrae +6 more
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Coil-helix transition of polypeptide at water-lipid interface [PDF]
, 2015 We present the exact solution of a microscopic statistical mechanical model for the transformation of a long polypeptide between an unstructured coil conformation and an $\alpha$-helix conformation.
Andreev, Oleg A. +4 more
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Conformal Connections and Conformal Transformations [PDF]
Transactions of the American Mathematical Society, 1959 Introduction. In the previous paper [5], we have studied the groups of projective transformations of affinely connected manifolds by the application of the theory of normal projective connections. The main purpose of the present paper is to study the conformal properties of complete Riemannian spaces of some special type by the application of the ...
openaire +2 more sources
Average Structures of a Single Knotted Ring Polymer
, 2008 Two types of average structures of a single knotted ring polymer are studied by Brownian dynamics simulations. For a ring polymer with N segments, its structure is represented by a 3N -dimensional conformation vector consisting of the Cartesian ...
Abagyan R. +23 more
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Geometric decomposition of the conformation tensor in viscoelastic turbulence
, 2018 This work introduces a mathematical approach to analysing the polymer dynamics in turbulent viscoelastic flows that uses a new geometric decomposition of the conformation tensor, along with associated scalar measures of the polymer fluctuations.
Gayme, Dennice F. +3 more
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Engineering of Cyclodextrin Product Specificity and pH Optima of the Thermostable Cyclodextrin Glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1 [PDF]
, 1998 The product specificity and pH optimum of the thermostable cyclodextrin glycosyltransferase (CGTase) from Thermoanaerobacterium thermosulfurigenes EM1 was engineered using a combination of x-ray crystallography and site-directed mutagenesis.
Bauke W. Dijkstra +44 more
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Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists [PDF]
, 2014 A knowledge-based library of aryl 2,3-dichlorophenylsulfonamides was synthesised and screened as human CCR4 antagonists, in order to identify a suitable hit for the start of a lead-optimisation programme.
Copley, R.C.B. +4 more
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Crystal structure of 2-methoxy-2-[(4-methoxyphenyl)sulfanyl]-1-phenylethanone
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title β-thiocarbonyl compound, C16H16O3S, the adjacent methoxy and carbonyl O atoms are synperiplanar [the O—C—C—O torsion angle is 19.8 (4)°] and are separated by 2.582 (3) Å.
Ignez Caracelli +5 more
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