Results 51 to 60 of about 1,012,378 (302)

A dual fluorescent-Raman bioorthogonal probe for specific biosynthetic labeling of intracellular gangliosides

Communications Chemistry
Gangliosides are sialic acid-containing glycosphingolipids integral to the cell membrane, and they are particularly abundant in the nervous system.
Mana Mohan Mukherjee, Matthew D. Watson, Devin Biesbrock, Lara K. Abramowitz, Steven K. Drake, Jennifer C. Lee, John A. Hanover   +6 more
doaj   +1 more source

Mechano-transduction: from molecules to tissues. [PDF]

, 2014
External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R, Nelson, W James, Pruitt, Beth L, Weis, William I   +3 more
core   +2 more sources

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation

Nature Communications
N- and C-terminal α-synuclein (α-syn) truncations are prevalent in Parkinson’s disease. Effects of the N- and C-terminal residues on α-syn aggregation and fibril propagation are distinct, where the N-terminus dictates fibril structure. Here, the majority
Ryan P. McGlinchey, Sashary Ramos, Emilios K. Dimitriadis, C. Blake Wilson, Jennifer C. Lee   +4 more
doaj   +1 more source

Crystal structure of (E)-4-methyl-N-{2-[2-(4-nitrobenzylidene)hydrazin-1-yl]-2-oxoethyl}benzenesulfonamide N,N-dimethylformamide monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2017
The molecule of the title Schiff base compound, C16H16N4O5S·C3H7NO, displays a trans conformation with respect to the C=N double bond. The C—N and N—N bonds are relatively short compared to their normal bond lengths, indicating some degree of ...
H. Purandara, Sabine Foro, B. Thimme Gowda   +2 more
doaj   +1 more source

How conformational changes can affect catalysis, inhibition and drug resistance of enzymes with induced-fit binding mechanism such as the HIV-1 protease

, 2013
A central question is how the conformational changes of proteins affect their function and the inhibition of this function by drug molecules. Many enzymes change from an open to a closed conformation upon binding of substrate or inhibitor molecules ...
Hemmateenejad, Bahram, Weikl, Thomas R.
core   +1 more source

Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek, Lori Wiener, Stephanie Veldhuijzen van Zanten, Donna Johnston, Fyeza Hasan, Adam Rapoport, Nathasha Datoo, Kimberley Widger, Sumit Gupta, Karen Fergus, Anthony K. C. Chan, Alisha Kassam, Emily McCullogh, Dave Lysecki   +13 more
wiley   +1 more source

Structure of 3-(3,5-Dimethylpiperidino)-\u3cem\u3eN\u3c/em\u3e-(\u3cem\u3ep\u3c/em\u3e-Chlorophenyl)Succinimide [PDF]

, 1993
In the title molecule, 3-(3,5-dimethylpiperidino )-1-(4-chlorophenyl)-2,5-pyrrolidinedione (1), the N-(p-chlorophenyl) substituent is rotated by 68.8° relative to the succinimide plane.
Igonin, V. A., Lindeman, Sergey V., Mendoza, V., Nava, Ezequiel Huipe, Struchkov, Yuri T.   +4 more
core   +1 more source

1,5-Bis(4-nitrophenoxy)pentane [PDF]

, 2009
The title compound, C17H18N2O6, crystallizes with two molecules in the asymmetric unit. In both molecules, one of the C-C bonds of the pentamethylene chain connecting the two aromatic rings is in a trans conformation and another displays a gauche ...
Muhammad Saif Ullah Khan, Zareen Akhter, Michael Bolte, M. Saeed Butt, Humaira M. Siddiqi, Faghihi, Hsiao, Hsiao, Mehdipour-Ataei, Mehdipour-Ataei, Schab-Balcerzak, Shao, Sheldrick, Spek   +13 more
core   +1 more source

Conformal Radii for Conformal Loop Ensembles [PDF]

Communications in Mathematical Physics, 2009
12 pages, v4 updates ...
Schramm, Oded, Sheffield, Scott, Wilson, David B.   +2 more
openaire   +4 more sources