Results 71 to 80 of about 663,489 (316)

Palmitoylation of A-kinase anchoring protein 79/150 modulates its nanoscale organization, trafficking, and mobility in postsynaptic spines

Frontiers in Synaptic Neuroscience, 2022
A-kinase anchoring protein 79-human/150-rodent (AKAP79/150) organizes signaling proteins to control synaptic plasticity. AKAP79/150 associates with the plasma membrane and endosomes through its N-terminal domain that contains three polybasic regions and ...
Xiaobing Chen, Kevin C. Crosby, Austin Feng, Alicia M. Purkey, Maria A. Aronova, Christine A. Winters, Virginia T. Crocker, Richard D. Leapman, Thomas S. Reese, Mark L. Dell’Acqua   +9 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Conformation-Induced Dynamical Heterogeneity of Water in the Solvation Shell of Zwitterionic γ‑Aminobutyric Acid

, 2019
The structure and dynamics of water molecules around the carboxylate and amino groups of γ-aminobutyric acid (GABA), a primary neurotransmitter in mammals, are investigated by means of ab initio molecular dynamics simulation.
Amalendu Chandra, Bikramjit Sharma, Amalendu Chandra (1570213), Bikramjit Sharma (1476895)   +3 more
core   +1 more source

Carcass characteristics of feedlot-finished Nellore heifers slaughtered at different weights

Acta Scientiarum: Animal Sciences, 2019
Carcass and meat characteristics of 48 Nellore heifers at 24 to 30 months of age, with an initial weight of 263.4 ± 13.9 kg, were evaluated. The experiment was set up as a completely randomized design with four treatments, which consisted of four ...
Pedro Leonardo de Paula Rezende, João Restle, Ubirajara Oliveira Bilego, Juliano José de Resende Fernandes, Regis Luis Missio, Tiago Pereira Guimarães   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural conformation of lipids at the oil-water interface

, 2012
This is the accepted version of this article. The final published version can be found here: http://dx.doi.org/10.1039/C2SM26028JA neutron reflectivity study of the phospholipid 1,2-distearoyl-sn-glycero-3-phosphocholine at the hexadecane–water interface
Zarbakhsh, Ali, Webster JRP, Zarbakhsh A, Webster, JRP, Campana, Mario, Lawrence, M. Jayne, Campana, M, Lawrence MJ, Webster, John R. P., Campana M, Zarbakhsh, A, Lawrence,, MJ   +11 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The C–F bond as a conformational tool in organic and biological chemistry

Beilstein Journal of Organic Chemistry, 2010
Organofluorine compounds are widely used in many different applications, ranging from pharmaceuticals and agrochemicals to advanced materials and polymers.
Luke Hunter
doaj   +1 more source

Effects of a quantitative trait locus for increased muscularity on carcass traits measured by subjective conformation and fat class scores and video image analysis in crossbred lambs

Animal, 2009
A quantitative trait locus (QTL) for increased loin muscularity (TM-QTL) has previously been identified in purebred Texel sheep. Crossbred lambs born out of Mule ewes mated to heterozygous Texel sires for the TM-QTL were evaluated for a range of carcass ...
E. Rius-Vilarrasa, R. Roehe, J.M. Macfarlane, N.R. Lambe, K.R. Matthews, W. Haresign, O. Matika, L. Bünger   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source