Results 81 to 90 of about 663,489 (316)

Conformation-Dependent Reversible Interaction of Ca2+/Calmodulin-Dependent Protein Kinase Kinase with an Inhibitor TIM-063

open access: yes, 2022
Ca2+/calmodulin-dependent protein kinase kinase (CaMKK), a Ca2+/CaM-dependent enzyme that phosphorylates and activates multifunctional kinases, including CaMKI, CaMKIV, protein kinase B/Akt, and 5′AMP-activated protein kinase, is involved in various Ca2+-
Naoki Kanayama (13691)   +21 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Conformation-Dependent Photochemistry of 5-Halouracil-Containing DNA:  Stereospecific 2‘α-Hydroxylation of Deoxyribose in Z-form DNA

open access: yes, 2016
Conformation-Dependent Photochemistry of 5-Halouracil-Containing DNA:  Stereospecific 2‘α-Hydroxylation of Deoxyribose in Z-form ...
Isao Saito (2455927)   +2 more
core   +1 more source

Aperçu des techniques d'analyse conformationnelle des macromolécules biologiques [PDF]

open access: yesBiotechnologie, Agronomie, Société et Environnement, 1998
Outline of conformational analysis techniques of the biological macromolecules. This paper presents a synthesis of thevarious methods of conformational analysis of biological macromolecules usually quoted in the literature.
Paquot M.   +3 more
doaj  

Conformation and Dynamics of the Cyclic Lipopeptide Viscosinamide at the Water-Lipid Interface

open access: yesMolecules, 2019
Cyclic lipodepsipeptides or CLiPs from Pseudomonas are secondary metabolites that mediate a wide range of biological functions for their producers, and display antimicrobial and anticancer activities.
Niels Geudens   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Conformal technicolor [PDF]

open access: yesJournal of High Energy Physics, 2006
26 pages + References. Slight wording changes.
Luty, Markus A., Okui, Takemichi
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Il professore immaginato e la valutazione come causa finale

open access: yesIm@go. A Journal of the Social Imaginary, 2015
The article, by assuming as main theoretical framework some French and Italian critical perspectives concerning the critical analysis of the “evaluation” dispositive and its cognitive and social consequences, focuses on a questionnaire to be answered by ...
Mino Conte
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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