Results 241 to 250 of about 3,454,137 (301)

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Interfacial Failure and Self‐Healing in Solid‐State Batteries

Advanced Materials, EarlyView.
Dynamic interfacial self‐healing offers an adaptive route to mitigate coupled mechanical, chemical, and electrochemical degradation in solid‐state batteries. This review connects evolving interfacial failure mechanisms with physical‐flow, chemical‐restoration, stimuli‐responsive, and electric‐field‐assisted repair strategies, highlighting targeted self‐
Xinxin Zhu, Tengfei Dai, Wendi Dou, Zhiheng Li, Kaihua Wen, Yanqun Lv, Ming Zhao, Jun Lu, Zaiping Guo   +8 more
wiley   +1 more source

Temperature-Dependent Conformational Dynamics of Substrate Entrance Loops in β-Glucosidase: Insights from Molecular Dynamics Simulations. [PDF]

Int J Mol Sci
Nam KH.
europepmc   +1 more source

Diketopyrrolopyrrole‐Based Cation as a Semiconducting Spacer in Layered Perovskite

Advanced Materials, EarlyView.
Diketopyrrolopyrrole cation incorporated layered perovskites exhibiting extended absorption profiles and enhanced charge carrier mobility with type‐II energy alignment. The improved photoconversion efficiency demonstrates the critical role of incorporating organic semiconductors in optimizing layered perovskite performance.
Waygen Thor, Colin Jeanguenat, Louise De Cian, Demetra Tsokkou, Parnian Ferdowsi, Nicolas J. Diercks, Natalie Banerji, Jun‐Ho Yum, Kevin Sivula   +8 more
wiley   +1 more source

Stability and Conformational Dynamics of Interferons: Structural Insights into the Urea- and Guanidinium Chloride-Induced Unfolding. [PDF]

ACS Omega
Aiman A, Ahmad F, Kataria P, Prakash A, Iram F, Khan T, Basir SF, Khan LA, Shahid M, Hassan MI, Islam A.   +10 more
europepmc   +1 more source

Electropolymerized Aptasensor for Femtogram‐Level Cytokine Detection

Advanced Materials, EarlyView.
Electropolymerization of 3‐amino‐ʟ‐tyrosine creates ultrathin, smooth, and chemically robust pALT nanofilms with accessible carboxyl functionalities for direct aptamer immobilization. Integrated with fiber‐optic SPR and OECT platforms, these interfaces enable IL‐6 detection down to 100 fg mL−1 and provide a versatile route to bioelectronic sensing ...
Jiyao Yu, Renan Colucci, Rachel X. Shi, Qi Lu, Tommaso Marchesi D'Alvise, Ulrike Kraft, Christopher V. Synatschke, Tanja Weil   +7 more
wiley   +1 more source

In silico conformational dynamics of the α-actinin-2 actin-binding domain upon phosphorylation. [PDF]

Biophys J
Tigro H, Childers MC, Regnier M, Solís C.   +3 more
europepmc   +1 more source

All‐Amyloid Functional Coacervates

Advanced Materials, EarlyView.
This study introduces an all‐amyloid interfacial complex coacervate technique that employs charge‐mediated or functionalization‐assisted complexation of oppositely charged food protein‐derived amyloid nanofibrils to engineer functional soft constructs across multiple length scales.
Seyyed Alireza Hashemi, Mohammad Peydayesh, Laura Baraldi, Mohammad Arjmand, Raffaele Mezzenga   +4 more
wiley   +1 more source

Simulating Freely Diffusing Single-Molecule FRET Data with Consideration of Protein Conformational Dynamics. [PDF]

J Phys Chem B
Losey J, Jauch M, Cortes-Cubero A, Wu H, Polasa A, Sauve S, Rivera R, Matteson DS, Moradi M.   +8 more
europepmc   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source