Results 151 to 160 of about 181,206 (262)

Conformational stability of hemocyanins regulates their lysosomal and proteasomal degradation, influencing their pro-inflammatory effects on mammalian antigen-presenting cells. [PDF]

Front Immunol
Salazar ML, d'Alençon C, Díaz-Dinamarca D, Bustamante J, Castillo B, Alvarado A, Salazar F, Manubens A, Becker MI.   +8 more
europepmc   +1 more source

Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design. [PDF]

Front Immunol, 2021
Riley TP, Chou HT, Hu R, Bzymek KP, Correia AR, Partin AC, Li D, Gong D, Wang Z, Yu X, Manzanillo P, Garces F.   +11 more
europepmc   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Thermodynamic versus kinetic basis for the high conformational stability of nanobodies for therapeutic applications. [PDF]

FEBS Lett
Gómez-Mulas A, Cano-Muñoz M, Salido Ruiz E, Pey AL.   +3 more
europepmc   +1 more source

Ion mobility mass spectrometry and molecular dynamics simulations unravel the conformational stability of zinc metallothionein-2 species.

Chem Commun (Camb), 2023
Peris-Díaz MD, Barkhanskiy A, Liggett E, Barran P, Krężel A.   +4 more
europepmc   +1 more source

Bacterial Luciferases from Vibrio harveyi and Photobacterium leiognathi Demonstrate Different Conformational Stability as Detected by Time-Resolved Fluorescence Spectroscopy. [PDF]

Int J Mol Sci, 2021
Nemtseva EV, Gulnov DV, Gerasimova MA, Sukovatyi LA, Burakova LP, Karuzina NE, Melnik BS, Kratasyuk VA.   +7 more
europepmc   +1 more source

Rational Design of Organic Chromophores for Simultaneously Trig‐gering Redox Imbalance and Tracking Organelles in Biological Sys‐tems Under Near‐Infrared Light Irradiation

Advanced Healthcare Materials, EarlyView.
TOC represents the synthesis of theory‐guided novel near‐infrared (NIR) light‐absorbing organic photosensitizers (OPS) enabling redox‐induced tumor phototherapy and single‐cell organelle tracking. ABSTRACT The design of organic photosensitizers that operate efficiently in the near‐infrared (NIR) region remains challenging due to the need to balance ...
Pragti, Bidyut Kumar Kundu, Jiajie Diao, Yujie Sun   +3 more
wiley   +1 more source

Correction: Pandey et al. Enhancing the Conformational Stability of the cl-Par-4 Tumor Suppressor via Site-Directed Mutagenesis. Biomolecules 2023, 13, 667. [PDF]

Biomolecules
Pandey S, Raut KK, Baudin A, Djemri L, Libich DS, Ponniah K, Pascal SM.   +6 more
europepmc   +1 more source

Similarities and differences in the conformational stability and reversibility of ORF8, an accessory protein of SARS-CoV-2, and its L84S variant. [PDF]

Biochem Biophys Res Commun, 2021
Ohki S, Imamura T, Higashimura Y, Matsumoto K, Mori M.   +4 more
europepmc   +1 more source

Tumor‐Targeted Hyaluronic Acid/Tannic Acid‐Engineered Oxygen Nanogenerators With IR780 Payloads Enable Dual‐Mode Glutathione Depletion and Effective Singlet Oxygen Generation for Melanoma Treatment

Advanced Healthcare Materials, EarlyView.
A hyaluronic acid/tannic acid‐engineered Prussian blue oxygen nanogenerator loaded with IR780 is developed to enhance melanoma phototherapy. By integrating tumor targeting, oxygen self‐supply, and dual‐mode glutathione depletion, the nanoplatform effectively overcomes hypoxia and antioxidant defenses, potentiating synergistic photothermal/photodynamic ...
Chai‐How Hsu, I‐Ju Liu, Hsiang‐Yun Chih, Tsai‐Ching Hsu, Ju‐An Liang, Chia‐Wei Kuo, Bor‐Show Tzang, Wen‐Hsuan Chiang   +7 more
wiley   +1 more source