Results 151 to 160 of about 755,354 (398)

Social learning strategies modify the effect of network structure on group performance

open access: yes, 2016
The structure of communication networks is an important determinant of the capacity of teams, organizations and societies to solve policy, business and science problems.
Barkoczi, Daniel, Galesic, Mirta
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

The Effectiveness of Physical Practices on the Reduction of Slow-Pace Students’ Aggression [PDF]

open access: yesرشد و یادگیری حرکتی ورزشی, 2009
The aim of this study was to determine the effectiveness of physical practices on the reduction of slow-pace children's aggression. For this purpose, 20 guidance school students with slow pace were selected through simple random sampling.
Gholamali Afrouz   +3 more
doaj  

BETWEEN THE RIGHT AND THE COMMON. HOW GROUPS REACT TO SOCIALLY UNDESIRABLE BEHAVIOUR

open access: yesStudies in Logic, Grammar and Rhetoric, 2017
The aim of the paper is to analyse the relationship between group characteristics and the scope of reaction of the group to socially undesirable behaviour.
Komendant-Brodowska Agata
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

General radiographic patient dose monitoring using conformity test data

open access: diamond, 2021
I Ketut Gede Darma Putra   +2 more
openalex   +2 more sources

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