Results 131 to 140 of about 139,209 (314)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Notre Dame Journal of Formal Logic, 1985 This is a discussion of some of the features of the author's systems of relevant logic, which he calls ''conforming'' relevant logics. They obey the principle of conformity to Boolean ordering: theorems are entailed by their negations. An example of a conforming relevant logic already in the literature is J. M. Dunn's R-Mingle.
openaire +2 more sources
Trends of Measuring Instruments Conformity Assessment
The aim of the paper is to show main points of measuring instruments conformity assessment to which need to pay attention and which can be changed in nearest future.
Liepiņa, Raimonda
core
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
The wedding paradox: individualised conformity
, 2015 Marriage rates are historically low, almost half of marriages end in divorce, and it has never been easier to live in other relationship forms like cohabitation and LAT (living apart together).
Carter, J.
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Wedding paradoxes: individualized conformity and the ‘perfect day’
, 2016 Marriage rates in 21st century Britain are historically low, divorce and separation are historically high, and marriage is no longer generally seen as necessary for legitimate sexual relationships, long-term partnership, or even parenting.
Simon Duncan +5 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Publications of the Research Institute for Mathematical Sciences, 1986 (From the author's introduction) ''By a conformal covariant we mean a holomorphic differential operator which intertwines two holomorphic representations of the conformal group SU(2,2). In this article we determine all such. [...] The determination of the set of covariant differential operators is equivalent to the determination of the set of ...
openaire +2 more sources