Results 51 to 60 of about 170,814 (256)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Another way of thinking: creativity and conformity [PDF]

, 2007
This paper explores possible tactics for academics working within a context of regulation and constraint. One tactic we suggest is moving outside of a creativity/conformity binary.
Harman, K, Harman, Kerry, Bohemia, E, Bohemia, Erik   +3 more
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Isolation and Genomic Profiling of Multi-Drug-Resistant pathogen Candidozyma auris, Including the New Clade VI, Through Wastewater Surveillance in Abu Dhabi, United Arab Emirates

Communications Medicine
Background Candidozyma auris (C auris) is an opportunistic, multidrug-resistant fungus associated with a high mortality rate and sustained transmission in both healthcare and environment settings, representing significant public health concerns.
Vinay Kusuma, Sumayya Almansoori, Bhuvaneshkumar Shanmugam, Surabhi Singh, Maryam AlQaydi, Siba Moussa, Grzegorz Brudecki, Shilp Purohit, Sharika Pariyachery, Shalini Behl, Samara Bin Salem, Tiago Magalhaes, Thyago Cardoso, Javier Quilez, Wael Elamin   +14 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A criterion for comparing measurement results and determining conformity with specifications [PDF]

In this paper a new criterion for comparing measurement results and determining conformity with specifications is proposed, which essentially is a strategy of estimating the empirical relationships of objects.
Ding, Hao, Jiang, Xiang, Scott, Paul J.
core   +3 more sources

Potential lighting and thermal demand reduction in office buildings using blind control considering surrounding buildings

Journal of Asian Architecture and Building Engineering, 2019
Automated blind control has been found to be more effective in controlling solar penetration than manual blind operation. Existing automated blind control methods mainly focus on improving indoor conditions, but considering the outside obstructions may ...
Woong June Chung, Chunde Liu, Yoon-Bok Seong   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Automated Evaluation of Layer Thickness Uniformity in 3D-Printed Cementitious Composites Using Deep Learning and Comparison with Manual Tracing Methods

Buildings
Layer thickness uniformity critically influences the dimensional accuracy and mechanical performance of large-scale cementitious structures produced by material extrusion 3D printing.
Jiseok Seo, Jun Lee, Bongchun Lee
doaj   +1 more source