Results 61 to 70 of about 170,814 (256)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Herding, Social Preferences and (Non-) Conformity [PDF]

We study the role of social preferences and conformity in explaining herding behavior in anonymous risky environments. In an experiment similar to information cascade settings, but with no private information, we find no evidence for conformity.
Ben Greiner, Luca Corazzini
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Investigation of Porcelain Plates Roughness Influence on Determination of Explosives Friction Sensitivity

Applied Sciences
The influence of the roughness of porcelain plates on the results of the friction sensitivity test of explosives was investigated. For this purpose, the roughness of selected batches of plates from several manufacturers (Julius Peters, OZM Research s.r.o.
Sonia Nachlik, Mateusz Pytlik
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Risks for the readymix concrete producer and contractor according to the acceptance or rejection criteria specified in different standards (part II)

Materiales de Construccion, 2006
This paper continues the work done on Part I included in this Volume. Based on the conformity and acceptance criteria analysed on Part I (1), EN 206-1:2000 (2) and AC/-318 (3) standards are studied and compared to EHE (4) standard described in Part l ...
D. M. Prada Betancourt, D. Revuelta Crespo, L. Fernández Luco, L. Vega Catalán   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

When In Rome: Conformity and the Provision of Public Goods [PDF]

We ask whether conformity, copying the most observed behavior in a population, can affect free riding in a public goods situation. Our model suggests that, if free riding is sufficiently frequent at the start of a public goods game, conformity will ...
Jeffrey Carpenter
core