Results 61 to 70 of about 752,008 (291)

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Congenital malformations among newborns admitted in the neonatal unit of a tertiary hospital in Enugu, South-East Nigeria - a retrospective study

BMC Research Notes, 2012
Background Congenital abnormalities are not uncommon among newborns and contribute to neonatal and infant morbidity and mortality. The prevalence and pattern of presentation vary from place to place.
Obu Herbert A, Chinawa Josephat M, Uleanya Nwachinemere D, Adimora Gilbert N, Obi Ikechukwu E   +4 more
doaj   +1 more source

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: systematic review [PDF]

, 2016
BACKGROUND The World Health Organization (WHO) stated in March 2016 that there was scientific consensus that the mosquito-borne Zika virus was a cause of the neurological disorder Guillain-Barré syndrome (GBS) and of microcephaly and other congenital ...
Porgo, Teegwendé V, Olufemi T. Oladapo (763006), Teegwendé V Porgo, Fabienne Krauer, Nathalie J. Broutet (3611078), Anina Haefliger, Broutet, Nathalie J, Anina Haefliger (3611081), Riesen, Maurane, Oladapo, Olufemi T, Nicola Low, Maurane Riesen (3611075), Nathalie J Broutet, Ruth Martínez-Vega (704834), Olufemi T Oladapo, Krauer, Fabienne, Maurane Riesen, Martínez-Vega, Ruth, Ludovic Reveiz (196131), Teegwendé V. Porgo (3611084), Ruth Martínez-Vega, Nicola Low (62560), Fabienne Krauer (103598), Ludovic Reveiz, WHO Zika Causality Working Group, Reveiz, Ludovic, Haefliger, Anina, Low, Nicola   +27 more
core   +2 more sources

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

MIS12 Is Required for Kinetochore‐Microtubule Attachment in Oocyte Meiosis

Advanced Science, EarlyView.
A model depicting the role of MIS12 in K‐MT attachment during oocyte meiosis. The presence of MIS12 stabilizes bipolar K‐MT attachments by maintaining the function of NDC80 and its interaction with TUBB. This, in turn, promotes KNL1 assembly and subsequent SAC protein recruitment to kinetochores.
Jian Li, Chun‐Hui Zhang, Yong Wang, Cheng‐Yuan Li, Da‐Rong Wen, Xi Xia, Liang Zhou, Wei‐Ping Qian, Qing‐Yuan Sun, Chang‐Zhong Li   +9 more
wiley   +1 more source

Clinical Implication and Ontological Basis of Bilobed Spleen: A Rare Case Report

Journal of Clinical and Diagnostic Research
Anatomical knowledge regarding the external morphology of the spleen is essential for surgical intervention and radiological diagnosis. A characteristic feature of the spleen is the presence of splenic notches at the superior border; however, such ...
Chaitanya Singh, Neelesh Kanaskar
doaj   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Insufficiency of Antenatal Ultrasonographic Examination to Detect Major Congenital Abnormalities in the Presence of Severe Oligohydramnios: A Case Report

Gynecology Obstetrics & Reproductive Medicine, 2008
Twenty years old patient was referred to our clinic from another state hospital with the diagnosis of oligohydramnios and intrauterin growth restriction (IUGR).
Metin Altay, Sinan Karadeniz, Okyar Erol, Yetkin Karasu, Orhan Gelişen, Ali Haberal   +5 more
doaj  

Validasi Ultrasonografi Transabdominal pada Luaran Kelainan Kongenital Janin di RSUP Dr. Hasan Sadikin Bandung Tahun 2018

Obgynia, 2020
Objective: The purpose of this study was to determine transabdominal ultrasound validation in detecting fetal congenital abnormalities in RSUP dr. Hasan Sadikin Bandung.
Yoga Paripurna, M. Rizkar Arev Sukarsa, Hanom Husni Syam, R. M. Sonny Sasotya, Adhi Pribadi, M. Alamsyah Aziz, Akhmad Yogi Pramatirta, Amillia Siddiq   +7 more
doaj   +1 more source