Results 91 to 100 of about 791,870 (310)

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Pulmonary arterial hypertension with left to right shunts: When to treat and/or close?

International Journal of Cardiology Congenital Heart Disease
Pulmonary arterial hypertension (PAH) is defined as increase in mean pulmonary arterial pressure and pulmonary vascular resistance (PVR). It can be associated with congenital heart disease (CHD) with the following subtypes: 1) uncorrected left-to-right ...
Michele D'Alto, Emanuele Romeo, Paola Argiento, Andrea Vergara, Eleonora Caiazza, Antonio Orlando, Rosa Franzese, Giancarlo Scognamiglio, Berardo Sarubbi, Konstantinos Dimopoulos   +9 more
doaj   +1 more source

Nucleoporin NUP205 plays a critical role in cilia and congenital disease. [PDF]

Dev Biol, 2021
Marquez J, Bhattacharya D, Lusk CP, Khokha MK.   +3 more
europepmc   +1 more source

Evidence for high levels of vertical transmission in Toxoplasma gondii [PDF]

, 2009
Toxoplasma gondii is a highly ubiquitous and prevalent parasite. Despite the cat being the only definitive host, it is found in almost all geographical areas and warm blooded animals. Three routes of transmission are recognised: ingestion of oocysts shed
Buxton, D. THOMASSON, Dubey, E. A. WRIGHT, E. K. MORLEY, G. HIDE, Hide, J. E. SMITH, J. M. HUGHES, K. H. ELMAHAISHI, M. S. ELMAHAISHI, O. GERWASH, R. G. MURPHY, R. H. WILLIAMS, Rodger   +14 more
core   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Generation of a new six1-null line in Xenopus tropicalis for study of development and congenital disease. [PDF]

Genesis, 2021
Coppenrath K, Tavares ALP, Shaidani NI, Wlizla M, Moody SA, Horb M.   +5 more
europepmc   +1 more source

Congenital Cystic Lung Diseases

Journal of Clinical Imaging Science, 2013
Congenital cystic diseases of the lung are a rare but significant cause of morbidity in children and young adults presenting with respiratory distress and repeated chest infections. They consist of cystic adenomatoid malformation, bronchogenic cyst, pulmonary sequestration, and congenital lobar emphysema.
Jain, Aditi, Anand, K, Singla, Saurabh, Kumar, Ashok   +3 more
openaire   +3 more sources

Tricuspid valve dysplasia in dogs [PDF]

, 2018
A general overview of tricuspid valve dysplasia in dogs is presented in this review. This congenital disease has been described in numerous large dog breeds but especially the Labrador retriever is predisposed.
Bavegems, Valérie, Broeckx, Bart, De Rooster, Hilde, Favril, Sophie, Peelman, Luc, Smets, Pascale   +5 more
core   +1 more source

How to improve the early diagnosis of Trypanosoma cruzi infection: Relationship between validated conventional diagnosis and quantitative DNA amplification in congenitally infected children [PDF]

, 2013
BACKGROUND: According to the Chagas congenital transmission guides, the diagnosis of infants, born to Trypanosoma cruzi infected mothers, relies on the detection of parasites by INP micromethod, and/or the persistence of T. cruzi specific antibody titers
Bua, Jacqueline Elena, Cardoni, Rita Liliana, de Rissio, Ana María, Perrone, Alina Elizabeth, Ruiz, Andrés Mariano, Scollo, Karenina, Velázquez, Elsa Beatriz, Volta, Bibiana Julieta   +7 more
core   +3 more sources

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, EarlyView.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source