Results 81 to 90 of about 756 (108)

Simultaneous detection of PNGase and ENGase activities in tissue lysate or cytosol using a simply designed high-mannose-type glycopeptide probe containing an Asn-leu-leu sequence.

Bioorganic & Medicinal Chemistry Letters
Endoplasmic reticulum-associated degradation facilitates the elimination of misfolded glycoproteins through a sequential process involving deglycosylation by cytosolic PNGase, followed by the removal of GlcNAc residues by ENGase.
Yuiko Kamata, N. Saito, Haruhiko Fujihira, Tadashi Suzuki, Mitsuaki Hirose, K. Totani   +5 more
semanticscholar   +1 more source

Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans

PLoS Biology
The conserved SKN-1A/Nrf1 transcription factor regulates the expression of proteasome subunit genes and is essential for maintenance of adequate proteasome function in animal development, aging, and stress responses.
Katherine S. Yanagi, Briar Jochim, Sheikh Omar Kunjo, Peter C. Breen, Gary Ruvkun, Nicolas J Lehrbach   +5 more
semanticscholar   +1 more source

An induced pluripotent stem cell-derived NMJ platform for study of the NGLY1-Congenital Disorder of Deglycosylation.

Advanced therapeutics
There are many neurological rare diseases where animal models have proven inadequate or do not currently exist. NGLY1 Deficiency, a congenital disorder of deglycosylation, is a rare disease that predominantly affects motor control, especially control of neuromuscular action. In this study, NGLY1-deficient, patient-derived induced pluripotent stem cells
Trevor, Sasserath, Ashley L, Robertson, Roxana, Mendez, Tristan T, Hays, Ethan, Smith, Helena, Cooper, Nesar, Akanda, John W, Rumsey, Xiufang, Guo, Atena, Farkhondeh, Manisha, Pradhan, Karsten, Baumgaertel, Matthew, Might, Steven, Rodems, Wei, Zheng, James J, Hickman   +15 more
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Novel NGLY1 gene variants in Chinese children with global developmental delay, microcephaly, hypotonia, hypertransaminasemia, alacrimia, and feeding difficulty

Journal of Human Genetics, 2020
Kuerbanjiang Abuduxikuer, Lin Zou, Lei Wang, Li Chen, Jian-She Wang   +4 more
semanticscholar   +1 more source

HILIC-UPLC-MS for high throughput and isomeric N-glycan separation and characterization in Congenital Disorders Glycosylation and human diseases

Glycoconjugate Journal, 2020
A. Messina, A. Palmigiano, F. Esposito, A. Fiumara, A. Bordugo, R. Barone, L. Sturiale, J. Jaeken, D. Garozzo   +8 more
semanticscholar   +1 more source

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa, Joyce M Slingerland   +1 more
exaly  

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

Ca-A Cancer Journal for Clinicians, 2020
Aaron J Grossberg, William L Hwang, Anirban Maitra   +2 more
exaly  

Oral complications of cancer and cancer therapy

Ca-A Cancer Journal for Clinicians, 2012
Joel B Epstein, Rene-Jean Bensadoun, Andrei Barasch   +2 more
exaly  

The financial burden and distress of patients with cancer: Understanding and stepping‐up action on the financial toxicity of cancer treatment

Ca-A Cancer Journal for Clinicians, 2018
Pricivel M Carrera, Hagop M Kantarjian, Victoria S Blinder   +2 more
exaly