The FASEB Journal, Volume 38, Issue 13, 15 July 2024.N‐glycosylation inhibitions by Tunicamycin (TUN) or by knockdown of phosphomannomutase 2 (PMM2) gene block the C2C12 myoblast fusion and impair the myogenic program. TUN treatment decreased myogenic markers and increased atrophy markers in muscles of WT and MLC/mIgf‐1 mice, which overexpress muscle Igf‐1Ea mRNA isoform.
Giosuè Annibalini +13 more
wiley +1 more source
Discovering the Hidden Power of NGLY1: Orchestrating Immune Cell Functions and Autoimmune Diseases
Frontiers in Bioscience-LandmarkThe enzyme N-glycanase 1 (NGLY1) regulates autophagic processes and endoplasmic reticulum (ER)-associated proteasomal degradation by de-N-glycosylation of misfolded glycoproteins.
Christina B. Brunner +6 more
doaj +1 more source
Molecular and Cell Biology of Infantile (CLN1) and variant Late Infantile (CLN5) Neuronal Ceroid Lipofuscinoses [PDF]
, 2003 Myös verkossa; väitöskirja, ohj.
Isosomppi, Juha
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α2δ3 is the preferred auxiliary α2δ subunit of Cav2.1 channels in spiral ganglion neurons and is required for development of auditory nerve fiber synapses [PDF]
, 2019 Voltage-gated calcium channels (VGCCs) are composed of a pore-forming α1 subunit and the auxiliary β and α2δ subunits. The largely extracellular α2δ proteins α2δ1-4 modulate the Ca2+ current properties but the reasons for their partial redundancy ...
Stephani, Friederike Lene Brigitte
core +1 more source
Depletion of Essential Isoprenoids and ER Stress Induction Following Acute Liver-Specific Deletion of HMG-CoA Reductase [PDF]
, 2020 HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and ...
Borchers, Christoph H +11 more
core +2 more sources
PROTEOMICS, Volume 24, Issue 1-2, January 2024.Abstract The Cys‐loop pentameric ligand‐gated ion channels comprise a dynamic group of proteins that have been extensively studied for decades, yielding a wealth of findings at both the structural and functional levels. The nicotinic acetylcholine receptor (nAChR) is no exception, as it is part of this large protein family involved in proper organismal
Rafael Maldonado‐Hernández +4 more
wiley +1 more source
Impact of truncated O-glycans in cancer associated CD44 variants [PDF]
, 2019 O-glycosylation is a post-translational modification misregulated in cancer and often correlated with poor prognosis and low overall survival. Particularly, truncated O-glycans, Tn and STn, are known as pancarcinoma markers.
Moreira, Inês Barbosa
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N-glycosylation as a regulatory process in the IGF-1 system: from mechanisms to clinical implications [PDF]
, 2020 open1nobiocellembargoed_20211221Di Patria, LauraDi Patria ...
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Identifying The Role Of The Type-Ii Transmembrane Serine Protease Tmprss13 In Breast Cancer [PDF]
, 2018 Breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death in women in the United States. Breast cancer progression is accompanied by increased expression of extracellular and cell surface proteases that are ...
Murray, Andrew Stevan
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Congenital alacrima in a 17-month-old boy: a case report [PDF]
, 2020 Alakrima je rijedak poremećaj koji označava smanjenu ili odsutnu proizvodnju suza i to se većinom očituje od rođenja. Može se javiti izolirano zbog urođene aplazije/hipoplazije ili poremećaja inervacije suzne žlijezde i pridruženih struktura, ali može ...
Adriana Bobinec +4 more
core +2 more sources