Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2
Cell Reports, 2023 Summary: Posttranslational modifications represent a key step in modulating programmed death-1 (PD-1) functions, but the underlying mechanisms remain incompletely defined. Here, we report crosstalk between deglycosylation and ubiquitination in regulating
Zhen Wu, Zhijie Cao, han Yao
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The impact of Fc glycosylation on IgG susceptibility to hinge region chemical reduction: implications for the development of immunoassays [PDF]
Biochemistry and Biophysics ReportsAntibodies are glycoproteins, and Fc glycosylation plays a critical structural role in maintaining the proper folding of the CH2 domain. Deglycosylated IgGs exhibit an open CH2 domain conformation that structurally affects also the neighboring hinge ...
Vanessa Susini +5 more
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Structure characterization and IgE-binding of soybean 7S globulin after enzymatic deglycosylation
International Journal of Food Properties, 2018 This study investigated the effects of enzymatic deglycosylation following ultrasound pretreatment on structure and immunoreactivity of soybean 7S globulin. Soybean 7S globulin was pretreated by ultrasound (40 kHz, 300 W) and enzymatically deglycosylated
Anshu Yang, Zhihua Wu, Ping Tong
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Deglycosylation induces a novel distal conformation in the mannose receptor CD206 [PDF]
Scientific ReportsDeglycosylation can disrupt protein structure and dynamics in ways that compromise function. In this study, we examine the structural and functional consequences of N-glycan removal in the mannose receptor CD206, a multi-domain lectin involved in innate ...
Guadalupe Alvarez +4 more
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Identification and characterization of the elusive protein backbone of the immuno-dominant and species-specific Em2(G11) metacestode antigen of Echinococcus multilocularis [PDF]
Frontiers in ParasitologyAlveolar echinococcosis (AE) caused by Echinococcus multilocularis, is a severe zoonotic disease in humans. One of the major metacestode antigens of E. multilocularis is the Em2 or Em2(G11) native purified antigen.
Philipp A. Kronenberg +13 more
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Frontiers in Chemistry, 2021 Reversible protein glycosylation and phosphorylation tightly modulate important cellular processes and are closely involved in pathological processes in a crosstalk dependent manner.
Cheng Chen, Xiaofei Zhang, Han Zhou
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Deglycosylation of eukaryotic-expressed flagellin restores adjuvanticity
npj Vaccines, 2023 Flagellin, the TLR5 agonist, shows potent adjuvant activities in diverse vaccines and immunotherapies. Vibrio vulnificus flagellin B expressed in eukaryotic cells (eFlaB) could not stimulate TLR5 signaling. Enzymatic deglycosylation restored eFlaB’s TLR5
Koemchhoy Khim +7 more
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Liver involvement in NGLY1 congenital disorder of deglycosylation [PDF]
Polish Journal of Pathology, 2020 N-glycanase 1 deficiency is a congenital disorder of deglycosylation, which has been diagnosed in 27 patients, including 2 of them from Poland. The most characteristic symptoms include global developmental disability, hyperkinetic movement disorder, hypo-
Patryk Lipiński +3 more
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NGLY1 deficiency—A rare congenital disorder of deglycosylation
JIMD Reports, 2020 AbstractPathogenic variants in the NGLY1 gene are associated with a Congenital Disorder of Deglycosylation (CDDG) characterized by delays in reaching developmental milestones, complex hyperkinetic movement disorder, transient elevation of transaminases, and alacrima or hypolacrima.
Patrícia Lipari Pinto
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Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions. [PDF]
, 2011 BackgroundOsteopontin (OPN) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family and a cytokine with diverse biologic roles.
Arjomandi, Mehrdad +5 more
core +16 more sources