Pharmacology Research & Perspectives, 2022 Anti‐proinflammatory cytokine therapies against interleukin (IL)‐6, tumor necrosis factor (TNF)‐α, and IL‐1 are major advancements in treating inflammatory diseases, especially rheumatoid arthritis.
Ikuno Uehara +7 more
doaj +1 more source
Deglycosylation of Gonadotropins with an Endoglycosidase
Experimental Biology and Medicine, 1986 A commercially available endoglycosidase (N-glycanase, Genzyme, Boston, Mass.) purified from Flavobacterium meningosepticum with a specificity for cleaving asparagine-linked carbohydrate moieties in glycoproteins was tested on several pituitary and chorionic gonadotropins as substrates.
Swedlow, Jason R. +2 more
openaire +3 more sources
Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation
eLife, 2020 During endoplasmic reticulum-associated degradation (ERAD), the cytoplasmic enzyme N-glycanase 1 (NGLY1) is proposed to remove N-glycans from misfolded N-glycoproteins after their retrotranslocation from the ER to the cytosol. We previously reported that
Antonio Galeone +13 more
doaj +1 more source
Metabolic profile, bioavailability and toxicokinetics of zearalenone-14-glucoside in rats after oral and intravenous administration by liquid chromatography high-resolution mass spectrometry and tandem mass spectrometry [PDF]
, 2019 Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity.
De Boevre, Marthe +9 more
core +1 more source
Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2
Frontiers in Pharmacology, 2022 Aim: The 20(S)-ginsenoside Rh2 (Rh2) is being developed as a new antitumor drug. However, to date, little is known about the kinetics of its deglycosylation metabolite (protopanoxadiol) (PPD) following Rh2 administration.
Hong-can Ren +20 more
doaj +1 more source
Applied Sciences, 2021 Platycosides are the functional saponins present in balloon flowers that exert diverse biological effects, and which can be further improved by their deglycosylation. Deapiose-xylosylated platycodin D, which is absent in balloon flowers, can be generated
Kyung-Chul Shin +5 more
doaj +1 more source
Trapping and Characterization of the Reaction Intermediate in Cyclodextrin Glycosyltransferase by Use of Activated Substrates and a Mutant Enzyme [PDF]
, 1997 Cyclodextrin glycosyltransferases (CGTases) catalyze the degradation of starch into linear or cyclic oligosaccharides via a glycosyl transfer reaction occurring with retention of anomeric configuration.
Dijkstra, Bauke W., +4 more
core +3 more sources
Liver Involvement in Congenital Disorders of Glycosylation and Deglycosylation [PDF]
Frontiers in Pediatrics, 2021 Background: Congenital disorders of glycosylation (CDG) and NGLY1-CDDG (NGLY1-congenital disorder of deglycosylation) usually represent multisystem (especially neurovisceral) diseases with liver involvement reported in some of them. The aim of the study was to characterize the liver phenotype in CDG and NGLY1-CDDG patients hospitalized in our Institute,
Patryk Lipiński +3 more
openaire +3 more sources
Frontiers in Microbiology, 2019 Resveratrol, a bioactive compound in high quantities in Polygonum cuspidatum, has well-known health benefits. However, it mainly exists in its glycosidic form, polydatin, in plants.
Chunqing Wang +10 more
doaj +1 more source
Role of glycosylation in secretion and stability of micromycetes α-galactosidase [PDF]
The Ukrainian Biochemical Journal, 2014 The effect of the glycosylation inhibitors (tunicamycin and 2-deoxy-D-glucose) on the activity, stability and production of fungal glycosidases has been studied.
N. V. Borzova +2 more
doaj +1 more source