Results 31 to 40 of about 17,182 (211)
Deglycosylation of Gonadotropins with an Endoglycosidase
Experimental Biology and Medicine, 1986 A commercially available endoglycosidase (N-glycanase, Genzyme, Boston, Mass.) purified from Flavobacterium meningosepticum with a specificity for cleaving asparagine-linked carbohydrate moieties in glycoproteins was tested on several pituitary and chorionic gonadotropins as substrates.
Swedlow, Jason R. +2 more
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N-terminal deletion of peptide:N-glycanase results in enhanced deglycosylation activity. [PDF]
PLoS ONE, 2009 Peptide:N-glycanase catalyzes the detachment of N-linked glycan chains from glycopeptides or glycoproteins by hydrolyzing the beta-aspartylglucosaminyl bond. Peptide:N-glycanase in yeast binds to Rad23p through its N-terminus.
Shengjun Wang +6 more
doaj +1 more source
Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2
Frontiers in Pharmacology, 2022 Aim: The 20(S)-ginsenoside Rh2 (Rh2) is being developed as a new antitumor drug. However, to date, little is known about the kinetics of its deglycosylation metabolite (protopanoxadiol) (PPD) following Rh2 administration.
Hong-can Ren +20 more
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Applied Sciences, 2021 Platycosides are the functional saponins present in balloon flowers that exert diverse biological effects, and which can be further improved by their deglycosylation. Deapiose-xylosylated platycodin D, which is absent in balloon flowers, can be generated
Kyung-Chul Shin +5 more
doaj +1 more source
Frontiers in Microbiology, 2019 Resveratrol, a bioactive compound in high quantities in Polygonum cuspidatum, has well-known health benefits. However, it mainly exists in its glycosidic form, polydatin, in plants.
Chunqing Wang +10 more
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Role of glycosylation in secretion and stability of micromycetes α-galactosidase [PDF]
The Ukrainian Biochemical Journal, 2014 The effect of the glycosylation inhibitors (tunicamycin and 2-deoxy-D-glucose) on the activity, stability and production of fungal glycosidases has been studied.
N. V. Borzova +2 more
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A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin [PDF]
The EMBO Journal, 2011 Oligosaccharide chains of newly synthesized membrane receptors are trimmed and modified to optimize their trafficking and/or signalling before delivery to the cell surface. For most membrane receptors, the functional significance of oligosaccharide chain modification is unknown.
Cao, Jinguo +7 more
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Deglycosylation is necessary but not sufficient for activation of proconcanavalin A [PDF]
Journal of Experimental Botany, 2001 Concanavalin A (ConA), one of the most studied plant lectins, is formed in jack bean (Canavalia ensiformis) seeds. ConA is synthesized as an inactive glycoprotein precursor proConA. Different processing events such as endoproteolytic cleavages, ligation of peptides and deglycosylation of the precursor are required to generate the different polypeptides
C, Ramis, V, Gomord, P, Lerouge, L, Faye
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Physiological Reports, 2020 The detection of erythropoietin (Epo) protein by Western blotting has required pre‐purification of the sample. We developed a new Western blot method to detect plasma and urinary Epo using deglycosylation.
Yukiko Yasuoka +17 more
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Therapeutic potential of deglycosylated antibodies [PDF]
Proceedings of the National Academy of Sciences, 2013 Autoimmune destruction of self tissue is the consequential result of a convergence of several factors, both genetic and environmental, that effectively dislocates the immune system’s ability to tolerate self-antigens but simultaneously retains its focus on those perceived as foreign.
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