Gerstmann-Sträussler-Scheinker disease revisited: accumulation of covalently-linked multimers of internal prion protein fragments [PDF]
, 2019 Despite their phenotypic heterogeneity, most human prion diseases belong to two broadly defined groups: Creutzfeldt-Jakob disease (CJD) and Gerstmann-Sträussler-Scheinker disease (GSS).
Cali, Ignazio +8 more
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Deglycosylation is necessary but not sufficient for activation of proconcanavalin A [PDF]
Journal of Experimental Botany, 2001 Concanavalin A (ConA), one of the most studied plant lectins, is formed in jack bean (Canavalia ensiformis) seeds. ConA is synthesized as an inactive glycoprotein precursor proConA. Different processing events such as endoproteolytic cleavages, ligation of peptides and deglycosylation of the precursor are required to generate the different polypeptides
C, Ramis, V, Gomord, P, Lerouge, L, Faye
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Studying Lactoferrin N-Glycosylation. [PDF]
, 2017 Lactoferrin is a multifunctional glycoprotein found in the milk of most mammals. In addition to its well-known role of binding iron, lactoferrin carries many important biological functions, including the promotion of cell proliferation and ...
Barile, Daniela +4 more
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Therapeutic potential of deglycosylated antibodies [PDF]
Proceedings of the National Academy of Sciences, 2013 Autoimmune destruction of self tissue is the consequential result of a convergence of several factors, both genetic and environmental, that effectively dislocates the immune system’s ability to tolerate self-antigens but simultaneously retains its focus on those perceived as foreign.
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A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin [PDF]
The EMBO Journal, 2011 Oligosaccharide chains of newly synthesized membrane receptors are trimmed and modified to optimize their trafficking and/or signalling before delivery to the cell surface. For most membrane receptors, the functional significance of oligosaccharide chain modification is unknown.
Cao, Jinguo +7 more
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Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule. [PDF]
, 1989 Neural cell adhesion molecule (N-CAM) is a membrane glycoprotein expressed on neural and muscle tissues that is involved in homotypic adhesive interactions.
Bindl, J +3 more
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OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair
Cell Death and Disease, 2021 Accumulated evidence shows that OGT-mediated O-GlcNAcylation plays an important role in response to DNA damage repair. However, it is unclear if the “eraser” O-GlcNAcase (OGA) participates in this cellular process.
Yaqi Cui +8 more
doaj +1 more source
Prion protein in the cerebrospinal fluid of healthy and naturally scrapie-affected sheep [PDF]
, 2006 The aim of this study was to characterize the cerebrospinal fluid (CSF) prion protein (PrP) of healthy and naturally scrapie-affected sheep. The soluble form of CSF PrPC immunoblotted with an anti-octarepeat and an anti-C terminus mAb showed two isoforms
Andréoletti +24 more
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Enzymatic deglycosylation of the dendrotoxin‐binding protein [PDF]
FEBS Letters, 1989 The neuronal membrane protein which binds the K+‐channel ligands dendrotoxin, mast cell degranulating peptide, and β‐bungarotoxin was purified from rat brain membranes. When analysed on 10% SDS gel electrophoresis, the purified protein contained two peptides: the toxin‐binding subunit of apparent M r, 90 000 and another peptide of M r, 38 000 ...
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CLONING OF THE 1.4-kb mRNA SPECIES OF HUMAN COMPLEMENT FACTOR H REVEALS A NOVEL MEMBER OF THE SHORT CONSENSUS REPEAT FAMILY RELATED TO THE CARBOXY TERMINAL OF THE CLASSICAL 150-kDa MOLECULE [PDF]
, 1991 Three factor H mRNA species of 4.3 kb, 1.8 kb, and 1.4 kb are constitutively expressed in human liver. Having previously characterized full-length cDNA clones derived from the 4.3-kb and 1.8-kb factor mRNA, we report here the isolation and eucaryotic ...
Dierich, Manfred P. +4 more
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