Results 11 to 20 of about 23,224 (220)

The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases [PDF]

Nature Communications
Corynebacterium diphtheriae clade species secrete single-domain endo-β-N-acetylglucosaminidases (ENGases) that specifically bind to human IgG antibodies and hydrolyze their N297-linked glycans.
Diego E. Sastre, Stylianos Bournazos, Maros Huliciak, Barbara Ann C. Grace, E. Josephine Boder, Jonathan Du, Nazneen Sultana, Tala Azzam, Trenton J. Brown, Maria W. Flowers, Pete Lollar, Ting Xu, Tatiana A. Chernova, Alasdair D. Keith, Meredith Keen, Abigail Saltzman, Ana Martinez Gascueña, Beatriz Trastoy, Marcelo E. Guerin, Filipp Frank, Eric A. Ortlund, Jeffrey V. Ravetch, Eric J. Sundberg   +22 more
doaj   +2 more sources

Effects of Roxadustat on Erythropoietin Production in the Rat Body

Molecules, 2022
Anemia is a major complication of chronic renal failure. To treat this anemia, prolylhydroxylase domain enzyme (PHD) inhibitors as well as erythropoiesis-stimulating agents (ESAs) have been used.
Yukiko Yasuoka, Yuichiro Izumi, Takashi Fukuyama, Haruki Omiya, Truyen D. Pham, Hideki Inoue, Tomomi Oshima, Taiga Yamazaki, Takayuki Uematsu, Noritada Kobayashi, Yoshitaka Shimada, Yasushi Nagaba, Tetsuro Yamashita, Masashi Mukoyama, Yuichi Sato, Susan M. Wall, Jeff M. Sands, Noriko Takahashi, Katsumasa Kawahara, Hiroshi Nonoguchi   +19 more
doaj   +1 more source

Progress in the Detection of Erythropoietin in Blood, Urine, and Tissue

Molecules, 2023
Detection of erythropoietin (Epo) was difficult until a method was developed by the World Anti-Doping Agency (WADA). WADA recommended the Western blot technique using isoelectric focusing (IEF)-PAGE to show that natural Epo and injected erythropoiesis ...
Yukiko Yasuoka, Yuichiro Izumi, Jeff M. Sands, Katsumasa Kawahara, Hiroshi Nonoguchi   +4 more
doaj   +1 more source

In Vitro Biotransformation of Total Glycosides in Qiwei Baizhu Powder by the Gut Microbiota of Normal and Diarrheal Mice: Novel Insight Into the Biotransformation of Multi-Glycosides by the Gut Microbiota

Frontiers in Chemistry, 2022
The gut microbiota (GM) is involved in the metabolism of glycosides and is beneficial for enhancing their bioactivity. However, the metabolism of multi-glycosides by the GM under normal and pathological conditions is unclear.
Guozhen Xie, Rongrong Zhou, Lili Huang, Shuihan Zhang, Zhoujin Tan   +4 more
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Exopolysaccharides Produced by Lactobacillus rhamnosus KL 53A and Lactobacillus casei Fyos Affect Their Adhesion to Enterocytes [PDF]

Polish Journal of Microbiology, 2018
Probiotics promote and help to maintain beneficial microbiota composition of the gastrointestinal tract ecosystem and have a positive impact on the host’s health. Production of exopolysaccharides is an important feature of probiotic lactobacilli.
CORINNA KONIECZNA, MARCIN T. SCHMIDT, MICHAŁ SŁODZIŃSKI   +2 more
doaj   +1 more source

Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines

G3: Genes, Genomes, Genetics, 2020
N-Glycanase 1 (NGLY1) deficiency is an ultra-rare, complex and devastating neuromuscular disease. Patients display multi-organ symptoms including developmental delays, movement disorders, seizures, constipation and lack of tear production.
William F. Mueller, Petra Jakob, Han Sun, Sandra Clauder-Münster, Sonja Ghidelli-Disse, Diana Ordonez, Markus Boesche, Marcus Bantscheff, Paul Collier, Bettina Haase, Vladimir Benes, Malte Paulsen, Peter Sehr, Joe Lewis, Gerard Drewes, Lars M. Steinmetz   +15 more
doaj   +1 more source

Reduction of Allergic Lung Disease by Mucosal Application of Toxoplasma gondii-Derived Molecules: Possible Role of Carbohydrates

Frontiers in Immunology, 2021
BackgroundThe hygiene hypothesis suggests a link between parasitic infections and immune disorders, such as allergic diseases. We previously showed that infection with Toxoplasma gondii or systemic application of T. gondii tachyzoites lysate antigen (TLA)
Elke Korb, Mirjana Drinić, Angelika Wagner, Nora Geissler, Aleksandra Inic-Kanada, Roman Peschke, Anja Joachim, Ursula Wiedermann, Irma Schabussova   +8 more
doaj   +1 more source

Effects of Angiotensin II on Erythropoietin Production in the Kidney and Liver

Molecules, 2021
The kidney is a main site of erythropoietin production in the body. We developed a new method for the detection of Epo protein by deglycosylation-coupled Western blotting.
Yukiko Yasuoka, Yuichiro Izumi, Takashi Fukuyama, Hideki Inoue, Tomomi Oshima, Taiga Yamazaki, Takayuki Uematsu, Noritada Kobayashi, Yoshitaka Shimada, Yasushi Nagaba, Masashi Mukoyama, Yuichi Sato, Jeff M Sands, Katsumasa Kawahara, Hiroshi Nonoguchi   +14 more
doaj   +1 more source

NGLY1 Deficiency, a Congenital Disorder of Deglycosylation: From Disease Gene Function to Pathophysiology

Cells, 2022
N-Glycanase 1 (NGLY1) is a cytosolic enzyme involved in removing N-linked glycans of misfolded N-glycoproteins and is considered to be a component of endoplasmic reticulum-associated degradation (ERAD).
Ashutosh Pandey, Joshua M. Adams, Seung Yeop Han, Hamed Jafar-Nejad   +3 more
doaj   +1 more source

N-terminal deletion of peptide:N-glycanase results in enhanced deglycosylation activity. [PDF]

PLoS ONE, 2009
Peptide:N-glycanase catalyzes the detachment of N-linked glycan chains from glycopeptides or glycoproteins by hydrolyzing the beta-aspartylglucosaminyl bond. Peptide:N-glycanase in yeast binds to Rad23p through its N-terminus.
Shengjun Wang, Fengxue Xin, Xiaoyue Liu, Yuxiao Wang, Zhenyi An, Qingsheng Qi, Peng George Wang   +6 more
doaj   +1 more source