Results 111 to 120 of about 3,750 (209)

Deficiency in COG5 causes a moderate form of congenital disorders of glycosylation [PDF]

, 2017
The conserved oligomeric Golgi (COG) complex is a tethering factor composed of eight subunits that is involved in the retrograde transport of intra-Golgi components. Deficient biosynthesis of COG subunits leads to alterations of protein trafficking along
Baumgartner, Matthias, Foulquier, François, Hennet, Thierry, Kleinert, Peter, Maag, Charlotte, Paesold-Burda, Patricie, Schnabel, Siegrun, Troxler, Heinz   +7 more
core  

The role of Alg13 N-acetylglucosaminyl transferase in the expression of pathogenic features of Candida albicans. [PDF]

, 2017
Background: The pathogenic potential of Candida albicans depends on adhesion to the host cells mediated by highly glycosylated adhesins, hyphae formation and growth of biofilm. These factors require effective N-glycosylation of proteins.
Janik, Anna, Kruszewska, Joanna S., Niewiadomska, Monika, Palamarczyk, Grazyna, Perlinska-Lenart, Urszula, Piłsyk, Sebastian   +5 more
core   +1 more source

Evolutionary rate covariation is pervasive between glycosylation pathways and points to potential disease modifiers.

PLoS Genetics
Mutations in glycosylation pathways, such as N-linked glycosylation, O-linked glycosylation, and GPI anchor synthesis, lead to Congenital Disorders of Glycosylation (CDG).
Holly J Thorpe, Raghavendran Partha, Jordan Little, Nathan L Clark, Clement Y Chow   +4 more
doaj   +1 more source

Clinical and whole-exome sequencing findings in two siblings from Hani ethnic minority with congenital glycosylation disorders

BMC Medical Genetics, 2019
Background PMM2-CDG, is the most common N-linked glycosylation disorder and subtype among all CDG syndromes, which are a series of genetic disorders involving the synthesis and attachment of glycoproteins and glycolipid glycans. The mutations of PMM2-CDG
Zhen Zhang, Ti-Long Huang, Jing Ma, Wen-Ji He, Huaiyu Gu   +4 more
doaj   +1 more source

Glycan Engineering for Cell and Developmental Biology [PDF]

, 2016
Cell-surface glycans are a diverse class of macromolecules that participate in many key biological processes, including cell-cell communication, development, and disease progression.
Griffin, Matthew E., Hsieh-Wilson, Linda C.   +1 more
core   +1 more source

Human plasma N-glycome stability [PDF]

, 2010
N-glikani su šećerne komponente glikoproteina čije su biološke funkcije za organizam vrlo važne te ponekad i esencijalne. Kod raznih bolesti (tumori, urođeni poremećaji glikozilacije, upalne bolesti) i stanja (alkoholizam), strukture glikana mogu biti ...
Mavrinac, Marina
core   +1 more source

Characterization of Cell Glycocalyx with Mass Spectrometry Methods. [PDF]

, 2019
The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function.
Lebrilla, Carlito B, Li, Qiongyu, Wong, Maurice, Xie, Yixuan   +3 more
core   +2 more sources

Differential effects of lobe A and lobe B of the Conserved Oligomeric Golgi complex on the stability of β1,4-galactosyltransferase 1 and α2,6-sialyltransferase 1 [PDF]

, 2017
Initially described by Jaeken et al. in 1980, congenital disorders of glycosylation (CDG) is a rapidly expanding group of human multisystemic disorders.
Duvet, Sandrine, Foulquier, François, Legrand, Dominique, Matthijs, Gert, Mir, Anne-Marie, Peanne, Romain, Rohrer, Jack   +6 more
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ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis [PDF]

, 2017
N-linked protein glycosylation follows a conserved pathway in eukaryotic cells. The assembly of the lipid-linked core oligosaccharide Glc3Man9GlcNAc2, the substrate for the oligosaccharyltransferase (OST), is catalyzed by different glycosyltransferases ...
Aebi, Markus, Frank, Christian G.
core  

Role of N-glycosylation in oral cancer [PDF]

, 2017
Oral squamous cell carcinoma represents more than 90% head and neck cancers with high incidence rate and morbidity. To date, little is known about the molecular mechanisms responsible for OSCC initiation and progression to advanced disease.
Bukhari, Samah
core