Results 31 to 40 of about 334,679 (233)

Gene-based genome-wide association studies and meta-analyses of conotruncal heart defects. [PDF]

, 2019
Conotruncal heart defects (CTDs) are among the most common and severe groups of congenital heart defects. Despite evidence of an inherited genetic contribution to CTDs, little is known about the specific genes that contribute to the development of CTDs ...
Agopian, AJ, Goldmuntz, Elizabeth, Hakonarson, Hakon, Mitchell, Laura E, Morrow, Bernice E, Pediatric Cardiac Genomics Consortium, Sewda, Anshuman, Taylor, Deanne   +7 more
core   +2 more sources

Metal nickel exposure increase the risk of congenital heart defects occurrence in offspring

Medicine, 2019
Background: Previous studies have investigated heavy metal exposure could increase the occurrence of congenital heart defects (CHDs). However, there are limited data regarding the relationship between exposure to nickel and CHDs occurrence in offspring ...
Nan-nan Zhang, Ming Chen, Jun Li, Ying Deng, Shengli Li, Yixiong Guo, Nana Li, Yuan Lin, Ping Yu, Zhen Liu, Jun Zhu   +10 more
semanticscholar   +1 more source

Patient attitudes to sternotomy and thoracotomy scars [PDF]

, 2005
Young adults with congenital heart defects expressed dissatisfaction with their surgical scar. The impact extended to their social life and ability to form close relationships, and has implications for holistic practice.
Burn, John, Crossland, David, Hamilton, Leslie, Hasan, Asif, Jackson, Sue, Lyall, Rosalind, O'Sullivan, John   +6 more
core   +1 more source

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing

Nature Genetics, 2016
Congenital heart defects (CHDs) have a neonatal incidence of 0.8–1% (refs. 1,2). Despite abundant examples of monogenic CHD in humans and mice, CHD has a low absolute sibling recurrence risk (∼2.7%), suggesting a considerable role for de novo mutations ...
A. Sifrim, M. Hitz, A. Wilsdon, J. Breckpot, S. A. Turki, B. Thienpont, J. McRae, Tomas W. Fitzgerald, T. Singh, G. Swaminathan, E. Prigmore, D. Rajan, H. Abdul-Khaliq, S. Banka, U. Bauer, J. Bentham, F. Berger, S. Bhattacharya, F. Bu'Lock, N. Canham, Irina Colgiu, C. Cosgrove, H. Cox, I. Daehnert, A. Daly, J. Danesh, A. Fryer, M. Gewillig, E. Hobson, K. Hoff, T. Homfray, A. Kahlert, A. Ketley, H. Kramer, K. Lachlan, Anne Katrin Lampe, J. Louw, Ashok Kumar Manickara, D. Manase, Karen P. McCarthy, K. Metcalfe, C. Moore, R. Newbury-Ecob, S. Omer, W. Ouwehand, Soo-Mi Park, M. Parker, T. Pickardt, Martin O Pollard, L. Robert, David J Roberts, J. Sambrook, Kerry Setchfield, B. Stiller, Chris Thornborough, O. Toka, H. Watkins, Denise Williams, M. Wright, S. Mital, P. Daubeney, B. Keavney, J. Goodship, R. Abu-Sulaiman, S. Klaassen, C. Wright, H. Firth, Jeffrey C. Barrett, K. Devriendt, David Fitzpatrick, J. Brook, M. Hurles   +71 more
semanticscholar   +1 more source

Dynamic Views of Structure and Function during Heart Morphogenesis [PDF]

, 2006
Congenital heart defects remain the most common birth defect in humans, occurring in over 1% of live births. The high prevalence of cardiac malformations can be partially attributed to limited knowledge regarding the embryonic roots of the disease.
Forouhar, Arian Soroush
core   +1 more source

Mental Health Among Parents of Children With Critical Congenital Heart Defects: A Systematic Review

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2017
Background Parents of children with critical congenital heart defects (PCCHDs) may be at high risk for mental health morbidity; however, the literature is not well characterized.
Sarah E. Woolf-King, Alexandra Anger, Emily A. Arnold, S. Weiss, D. Teitel   +4 more
semanticscholar   +1 more source

Congenital Abnormalities of the Fetal Heart [PDF]

, 2018
Congenital heart defects (CHDs) are the most frequent congenital malformations, the costliest hospital admissions for structural defects and the leading cause of infant general and malformations related mortality.
Cara, Laura Monica, Ceausu, Iuliana, Cirstoiu, Monica Mihaela, Drăgușin, Roxana Cristina, Iliescu, Dominic Gabriel, Marginean, Claudiu, Muresan, Cezara, Muresan, Daniel, Nemescu, Dragos, Patru, Ciprian Laurentiu, Sorop-Florea, Maria, Tudorache, Ștefania, Vicea, Marius Calomfirescu, Vlădăreanu, Simona, Zvanca, Mona Elena   +14 more
core   +1 more source

Association Between Maternal Folic Acid Supplementation and Congenital Heart Defects in Offspring in Birth Cohorts From Denmark and Norway

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2019
Background Evidence linking individual‐level maternal folic acid supplementation to offspring risk of congenital heart defects is lacking. We investigated whether folic acid supplementation in early pregnancy reduces offspring risk of heart defects in 2 ...
N. Øyen, S. Olsen, S. Basit, E. Leirgul, M. Strøm, L. Carstensen, C. Granström, G. Tell, P. Magnus, S. Vollset, J. Wohlfahrt, M. Melbye   +11 more
semanticscholar   +1 more source

Folate supplementation for prevention of congenital heart defects and low birth weight: an update.

Cardiovascular Diagnosis and Therapy, 2019
Women planning a pregnancy and pregnant women in the first trimester are recommended to use folate-containing supplements in order to prevent neural tube defects.
R. Obeid, W. Holzgreve, K. Pietrzik
semanticscholar   +1 more source

Tessier number 30 clefts with congenital heart defects [PDF]

, 2015
Introduction: Midline cleft of mandible, classified as Tessier 30 clefts is extremely rare, with less than 100 reported cases in the latest studies. Variations in severity and associated malformations have been reported before. Case Presentation: In this
Aminolsharieh Najaf, S., Hasheminejad, R., Mirfazeli, A., Shafee, A., Tafreshi, M.   +4 more
core   +1 more source