Results 41 to 50 of about 172,842 (307)

Human gene copy number spectra analysis in congenital heart malformations [PDF]

, 2012
The clinical significance of copy number variants (CNVs) in congenital heart disease (CHD) continues to be a challenge. Although CNVs including genes can confer disease risk, relationships between gene dosage and phenotype are still being defined.
Bick, David P., Broeckel, Ulrich, Goetsch, Mary A., Harris, Susan, Hidestrand, Mats, Mahnke, Donna K., Mitchell, Michael, Pelech, Andrew N., Simpson, Pippa, Stamm, Karl D., Struble, Craig, Tomita-Mitchell, Aoy, Tuffnell, Maureen E., Tweddell, James S.   +13 more
core   +2 more sources

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, EarlyView.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

Bridging clinical care and lived experience: early implementation of longitudinal health-related quality of life monitoring in congenital heart disease

Frontiers in Pediatrics
BackgroundCongenital heart defects (CHD) are the most common congenital malformations, and, although survival rates now exceed 90%, children remain at risk for long-term psychomotor, cognitive, and psychosocial difficulties.
Jana Willems, Philipp A. Müller, Anna Erbers, Franziska Renninger, Alina Stricker, Vera König, Rouven Kubicki, Hannah E. Kappler, Alexej Bobrowski, Brigitte Stiller, Christoph Zürn   +10 more
doaj   +1 more source

Pentalogy of Cantrell : the first Maltese case with successful outcome [PDF]

, 1997
Pentalogy of Cantrell is a rare disorder which was first described by Cantrell and his colleagues in 1958. It is comprised of congenital heart disease and midline defects.
Grech, Victor E., Parascandalo, Raymond, Rees, Philip G.   +2 more
core  

Detection rates of congenital heart disease in Guatemala [PDF]

, 2010
ObjectivesIn developing countries, congenital heart disease is often unrecognised, leading to serious morbidity and mortality. Guatemala is one of the few developing countries where expert paediatric cardiac treatment is available and affordable, and ...
Barnoya, Joaquin, Castañeda, Aldo, Larrazabal, Luis A, Teitel, David F, Trucco, Sara M   +4 more
core   +2 more sources

Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare

Advanced Robotics Research, EarlyView.
Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin, Jimin Kim, Inho Kim, Bong Hoon Kim   +3 more
wiley   +1 more source

Quality of life in children with infrequent congenital heart defects: cohort study with one-year of follow-up

Health and Quality of Life Outcomes, 2020
Background The evidence regarding patient related outcomes in children with infrequent congenital heart defects (I-CHD) is very limited. We sought to measure quality of life (QoL) in children with I-CHD, and secondarily, to describe QoL changes after one-
Karen Moreno-Medina, Magally Barrera-Castañeda, Catalina Vargas-Acevedo, Alberto E. García-Torres, Miguel Ronderos, Manuel Huertas-Quiñones, Silvana Cabrera, María Teresa Domínguez, Nestor Sandoval Reyes, Rodolfo J. Dennis   +9 more
doaj   +1 more source

Utility of deep learning networks for the generation of artificial cardiac magnetic resonance images in congenital heart disease

BMC Medical Imaging, 2020
Background Deep learning algorithms are increasingly used for automatic medical imaging analysis and cardiac chamber segmentation. Especially in congenital heart disease, obtaining a sufficient number of training images and data anonymity issues remain ...
Gerhard-Paul Diller, Julius Vahle, Robert Radke, Maria Luisa Benesch Vidal, Alicia Jeanette Fischer, Ulrike M. M. Bauer, Samir Sarikouch, Felix Berger, Philipp Beerbaum, Helmut Baumgartner, Stefan Orwat, for the German Competence Network for Congenital Heart Defects Investigators   +11 more
doaj   +1 more source

Complex cardiac defects after ethanol exposure during discrete cardiogenic events in zebrafish: prevention with folic acid [PDF]

, 2013
Fetal alcohol spectrum disorder (FASD) describes a range of birth defects including various congenital heart defects (CHDs). Mechanisms of FASD-associated CHDs are not understood.
Marrs, James A., Swapnalee, Sarmah
core   +1 more source