Results 41 to 50 of about 245,105 (180)

Glucocorticoid-Induced Hyperinsulinism in a Preterm Neonate with Inherited ABCC8 Variant

Metabolites, 2022
Glucose homeostasis is a real challenge for extremely preterm infants (EPIs) who have both limited substrate availability and immature glucose metabolism regulation.
Emmanuelle Motte-Signoret, Cécile Saint-Martin, Christine Bellané-Chantelot, Bernard Portha, Pascal Boileau   +4 more
doaj   +1 more source

Congenital hyperinsulinism in newborns and young children: the state of the problem and the results of surgical treatment

Медицинский совет, 2021
Congenital hyperinsulinism causes irreversible damage to the cerebral cortex with subsequent disability in children. The article presents the features of etiopathogenesis, clinical picture of the disease.
A. A. Sukhotskaya, V. G. Bairov, I. L. Nikitina, L. B. Mitrofanova, A. A. Perminova, D. V. Ryzhkova   +5 more
doaj   +1 more source

Therapies and outcomes of congenital hyperinsulinism-induced hypoglycaemia

, 2019
Congenital hyperinsulinism is a rare disease, but is the most frequent cause of persistent and severe hypoglycaemia in early childhood. Hypoglycaemia caused by excessive and dysregulated insulin secretion (hyperinsulinism) from disordered pancreatic β ...
Shah, P, Nicholson, J., Salomon Estebanez, Maria, Banerjee, Indraneel, Dunne, Mark, Cosgrove, Karen   +5 more
core   +1 more source

Inheritance of a paternal ABCC8 variant and maternal loss of heterozygosity at 11p15 retrospectively unmasks the etiology in a case of Congenital hyperinsulinism

Clinical Case Reports, 2020
Advances in genomics and 18F‐DOPA PET‐CT imaging have transformed the management of infants with Congenital Hyperinsulinism. Preoperative diagnosis of focal hyperinsulinism permits limited pancreatectomy with improved clinical outcomes while knowledge of
Caroline M. Joyce, Jayne A. Houghton, Domhnall J. O’Halloran, Paula M. O’Shea, Susan M. O’Connell   +4 more
doaj   +1 more source

Familial Hyperinsulinism due to HNF4A Deficiency and Benign Premature Adrenarche: A Case Report

International Journal of Medical Students, 2021
Background: Familial Hyperinsulinism due to HNF4A deficiency (FHI-HNF4A) is a form of diazoxide-sensitive, diffuse hyperinsulinism, characterized by transient or persistent hyperinsulinemic hypoglycemia, and a propensity to develop Maturity-Onset ...
Edward Compton, David H. Geller, Alaina Vidmar   +2 more
doaj   +1 more source

Congenital hyperinsulinism and mosaic abnormalities of the ploidy.

, 2006
BACKGROUND: Congenital hyperinsulinism and Beckwith-Wiedemann syndrome both lead to beta islet hyperplasia and neonatal hypoglycaemia. They may be related to complex genetic/epigenetic abnormalities of the imprinted 11p15 region.
Rahier, J., Nihoul-Fékété, C., Hubert, L, Brunelle, F., Bellanné-Chantelot, C, Henquin, J. C., de Lonlay, P, Giurgea, I, De Lonlay, P., Rahier, Jacques, Robert, J. J., Vekemans, M, Groos, M. S., Dunne, M. J., Fournet, J-C, Touati, G, Jaubert, F., Dunne, M J, Junien, C., Vekemans, M., Jaubert, F, Robert, J-J, Bellanné-Chantelot, C., Sempoux, Christine, Sempoux, C., Sanlaville, D, Touati, G., Groos, M-S, Henquin, Jean-Claude, Sanlaville, D., Giurgea, Irina, Fournet, J. C., Brunelle, F, Nihoul-Fékété, C, Hubert, L.   +34 more
core   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Case Report: The importance of genetic counseling for families with hyperinsulinism

Frontiers in Pediatrics
Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in infancy. Genotype-phenotype correlations directly inform medical care for patients.
Victoria R. Sanders, Victoria R. Sanders, Katherine Lord, Katherine Lord, Katherine Lord, Winnie M. Sigal, Winnie M. Sigal, Winnie M. Sigal, Heather McKnight, Heather McKnight, N. Scott Adzick, N. Scott Adzick, Lisa J. States, Lisa J. States, Tricia Bhatti, Tricia Bhatti, Diva D. De Leon, Diva D. De Leon, Diva D. De Leon   +18 more
doaj   +1 more source

Gestational diabetes in multifetal versus singleton pregnancies: A multicenter cohort study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Gestational diabetes in multifetal pregnancies was associated with increased maternal morbidity but less adverse neonatal and long‐term offspring outcomes than in singleton pregnancies, suggesting that current diagnostic thresholds derived from singleton gestations may not fully reflect the unique metabolic and clinical characteristics of multifetal ...
Rinat Gabbay‐Benziv, Esther Maor‐Sagie, Amos Stern, Inna Bleicher, Simon Shenhav, Enav Yefet, Yifat Wiener, Michal Kovo, Maya Frank Wolf   +8 more
wiley   +1 more source

Congenital hyperinsulinsim: case report and review of literature

The Pan African Medical Journal, 2020
Neonatal hypoglycemia (NH) is one of the most common abnormalities encountered in the newborn. Hypoglycemia continues to be an important cause of morbidity in neonates and children.
Brahim El Hasbaoui, Abdelhkim Elyajouri, Rachid Abilkassem, Aomar Agadr   +3 more
doaj   +1 more source