From standard to individualized diazoxide therapy in congenital hyperinsulinism: a narrative review [PDF]
Frontiers in PharmacologyPurposeCongenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycaemia in neonates and infants (blood glucose <3.0 mmol/L in first 2–3 days of life; <3.5 mmol/L after 3 days of life).
Teresa Wong +10 more
doaj +2 more sources
Combined Effects of Diazoxide and Moderate-Intensity Exercise on the Restoration of Redox Balance Post-Fatigue in Fast- and Slow-Twitch Skeletal Muscles of Hypertensive Rats [PDF]
BiologyMuscle fatigue, defined as a decline in force generation, is closely linked to redox imbalance—a condition exacerbated by oxidative stress in hypertension. This study investigated the effects of diazoxide administration and moderate-intensity exercise on
Estefanía Bravo-Sánchez +10 more
doaj +2 more sources
Safety and feasibility of hyperkalemic cardioplegia with diazoxide in cardiac surgery: The Cardioplegia with Diazoxide in Cardiac Surgery TrialCentral MessagePerspective [PDF]
JTCVS OpenBackground: We have demonstrated cardioprotection by the adenosine triphosphate–sensitive potassium (KATP) channel opener diazoxide in multiple animal models in an effort to reduce myocardial stunning following cardiac surgery.
AlleaBelle Bradshaw, MD +7 more
doaj +2 more sources
Real-world experience with the use of diazoxide among people living with congenital hyperinsulinism and their caregivers [PDF]
Frontiers in EndocrinologyIntroductionCongenital hyperinsulinism (HI) is a rare disease that causes severe hypoglycemia. Diazoxide is the first-line treatment; however, many individuals using diazoxide continue to experience hypoglycemia. Diazoxide is associated with side effects
Tai L. S. Pasquini +8 more
doaj +2 more sources
A case of insulinoma effectively treated with low‐dose diazoxide
Clinical Case Reports (discontinued), 2020 Diazoxide is a benzothiadiazine that can be effective in managing hypoglycemia in frail patients with surgical risk. We report here a case of insulinoma effectively treated with diazoxide, as our report will be helpful for similar cases.
Atsushi Yasuda +2 more
exaly +2 more sources
Trisomy 13 as a risk factor for pulmonary hypertension induced by diazoxide [PDF]
Annals of Pediatric CardiologyIntroduction: Diazoxide has been used globally for hyperinsulinemic hypoglycemia. However, serious adverse drug reactions, such as pulmonary hypertension (PH), are major concerns.
Kazu Ishikawa +4 more
doaj +2 more sources
Identification of an ABCC8 variant in a kindred with transient diazoxide responsive hyperinsulinism [PDF]
Endocrinology, Diabetes & Metabolism Case ReportsCongenital hyperinsulinism is a rare disorder characterized by hypoglycemia and inappropriately elevated insulin levels. The genetics of congenital hyperinsulinism is complex, with the most common cause being pathogenic variants in the ATP-sensitive ...
Ryan L Smith, Stephen I Stone
doaj +2 more sources
Heliyon, 2023 Diazoxide is a potential candidate for the treatment of transitional hypoglycaemia in infants. A clinical trial is currently underway to investigate whether low-dose oral diazoxide is beneficial for severe or recurrent transitional neonatal hypoglycaemia
Trusha J. Purohit +4 more
doaj +1 more source
Diazoxide is a powerful cardioprotectant but is not feasible in a realistic infarct scenario
Frontiers in Cardiovascular Medicine, 2023 IntroductionDiazoxide is a powerful cardioprotective agent that activates mitochondrial ATP-dependent K-channels and stimulates mitochondrial respiration.
Petra Kleinbongard +3 more
doaj +1 more source
Diazoxide-Induced Hypertrichosis in a Neonate With Transient Hyperinsulinism
Clinical Medicine Insights: Case Reports, 2023 Diazoxide is one of the FDA-approved pharmacologic treatments for hyperinsulinemic hypoglycemia, however, its adverse effects in infants are not well described. We reported a 37-week-old boy with the diagnosis of hypoglycemia.
Seyyed Javad Boskabadi +3 more
doaj +1 more source