Results 1 to 10 of about 6,140 (153)

Clinical Report and Genetic Analysis of a Patient With Congenital Hyperinsulinism Hyperammonemia Caused by a Novel Missense Mutation in the Structural Domain of the Isoform of the GLUD1 Gene. [PDF]

Clin Case Rep
This patient was admitted to the hospital 43 h after birth with convulsions and hypoglycemia, presenting as recurrent refractory hypoglycemia that was difficult to control with conventional medication. Whole exome sequencing detected the GLUD1 (NM_005271.3:c.1495G>T, p.Gly499Cys) variant, which was a de novo variant in the patient and was not detected ...
Li T, Liu T, Li L, Liu Y, Zhang Q, Cheng X, Li Z.   +6 more
europepmc   +2 more sources

From standard to individualized diazoxide therapy in congenital hyperinsulinism: a narrative review [PDF]

Frontiers in Pharmacology
PurposeCongenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycaemia in neonates and infants (blood glucose <3.0 mmol/L in first 2–3 days of life; <3.5 mmol/L after 3 days of life).
Teresa Wong, Daniel Chan, Daniel Chan, Cherie Chua, Cherie Chua, Wenqi Cher, Selina Lim, Suresh Chandran, Suresh Chandran, Fabian Yap, Fabian Yap   +10 more
doaj   +2 more sources

Combined Effects of Diazoxide and Moderate-Intensity Exercise on the Restoration of Redox Balance Post-Fatigue in Fast- and Slow-Twitch Skeletal Muscles of Hypertensive Rats [PDF]

Biology
Muscle fatigue, defined as a decline in force generation, is closely linked to redox imbalance—a condition exacerbated by oxidative stress in hypertension. This study investigated the effects of diazoxide administration and moderate-intensity exercise on
Estefanía Bravo-Sánchez, César J. Nolasco-Ruiz, Sarai Sánchez-Duarte, Mariana Gómez-Barroso, Manuel Alejandro Vargas-Vargas, Christian Cortés-Rojo, Salvador Manzo-Ávalos, Elizabeth Sánchez-Duarte, Alain Raimundo Rodríguez-Orozco, Alfredo Saavedra-Molina, Rocío Montoya-Pérez   +10 more
doaj   +2 more sources

Safety and feasibility of hyperkalemic cardioplegia with diazoxide in cardiac surgery: The Cardioplegia with Diazoxide in Cardiac Surgery TrialCentral MessagePerspective [PDF]

JTCVS Open
Background: We have demonstrated cardioprotection by the adenosine triphosphate–sensitive potassium (KATP) channel opener diazoxide in multiple animal models in an effort to reduce myocardial stunning following cardiac surgery.
AlleaBelle Bradshaw, MD, Jessica B. Briscoe, MD, Lisa Fornaresio, PhD, Zyriah Robinson, BS, Michelle Carvajal Villalba, MD, Shivani Shirodkar, MBBS, MPH, Hamza Aziz, MD, Jennifer S. Lawton, MD   +7 more
doaj   +2 more sources

Real-world experience with the use of diazoxide among people living with congenital hyperinsulinism and their caregivers [PDF]

Frontiers in Endocrinology
IntroductionCongenital hyperinsulinism (HI) is a rare disease that causes severe hypoglycemia. Diazoxide is the first-line treatment; however, many individuals using diazoxide continue to experience hypoglycemia. Diazoxide is associated with side effects
Tai L. S. Pasquini, Kristen E. Rohli, Fiona J. Almeida, Indraneel Banerjee, Antonia Dastamani, Diva D. De Leon, Lauren N. Lopez, Paul S. Thornton, Julie Raskin   +8 more
doaj   +2 more sources

Recurrent Hypoglycemia in Two Late‐Preterm Infants With Transitional Disorder of Glucose Mobilization—Case Series [PDF]

Clin Case Rep
Timeline of events. ABSTRACT Great emphasis is placed upon addressing hyperinsulinism in at‐risk infants with recurrent hypoglycemia. We report two preterm infants with recurrent nonhyperinsulinemic hypoglycemia due to transient impairment of glucose mobilization, warranting diazoxide use.
Chandran S, Ting Y, Abhirami S, Yap F.
europepmc   +2 more sources

Hypoglycemia Occurrence and Risk Factors in Insulin Independent Patients After Total Pancreatectomy With Islet Autotransplantation. [PDF]

Clin Transplant
ABSTRACT Background Total pancreatectomy with islet auto‐transplantation (TPIAT) alleviates pain and preserves islet function in patients with severe pancreatitis. Although approximately one third of recipients achieve insulin independence, spontaneous hypoglycemia has been observed in this population. Its frequency, risk factors, and management remain
Hassaan A, Eaton A, Jagadesh N, Trikudanathan G, Freeman M, Downs E, Chinnakotla S, Martin D, Ramanathan K, Beilman GJ, Bellin MD.   +10 more
europepmc   +2 more sources

A case of insulinoma effectively treated with low‐dose diazoxide

Clinical Case Reports (discontinued), 2020
Diazoxide is a benzothiadiazine that can be effective in managing hypoglycemia in frail patients with surgical risk. We report here a case of insulinoma effectively treated with diazoxide, as our report will be helpful for similar cases.
Toshiro Seki, Masami Seki, Atsushi Yasuda   +2 more
exaly   +2 more sources

Trisomy 13 as a risk factor for pulmonary hypertension induced by diazoxide [PDF]

Annals of Pediatric Cardiology
Introduction: Diazoxide has been used globally for hyperinsulinemic hypoglycemia. However, serious adverse drug reactions, such as pulmonary hypertension (PH), are major concerns.
Kazu Ishikawa, Hiro Nakao, Daisuke Shinjo, Mitsuru Kubota, Akira Ishiguro   +4 more
doaj   +2 more sources

Identification of an ABCC8 variant in a kindred with transient diazoxide responsive hyperinsulinism [PDF]

Endocrinology, Diabetes & Metabolism Case Reports
Congenital hyperinsulinism is a rare disorder characterized by hypoglycemia and inappropriately elevated insulin levels. The genetics of congenital hyperinsulinism is complex, with the most common cause being pathogenic variants in the ATP-sensitive ...
Ryan L Smith, Stephen I Stone
doaj   +2 more sources