Results 41 to 50 of about 12,087 (179)

Partial diazoxide responsiveness in a neonate with hyperinsulinism due to homozygous ABCC8 mutation

Endocrinology, Diabetes & Metabolism Case Reports, 2019
We report a case of partial diazoxide responsiveness in a child with severe congenital hyperinsulinaemic hypoglycaemia (CHI) due to a homozygous ABCC8 mutation.
Sarah Kiff, Carolyn Babb, Maria Guemes, Antonia Dastamani, Clare Gilbert, Sarah E Flanagan, Sian Ellard, John Barton, M Dattani, Pratik Shah   +9 more
doaj   +1 more source

Clinical and Molecular Characterisation Of Hyperinsulinaemic Hypoglycaemia In Infants Born Small-For-Gestational Age [PDF]

, 2013
OBJECTIVE: To characterise the phenotype and genotype of neonates born small-for-gestational age (SGA; birth weight 6 months. Normoglycaemia on diazoxide
Arya, Ved Bhushan, Ellard, Sian, Flanagan, Sarah E, Hamilton-Shield, Julian P, Hussain, Khalid, Kapoor, Ritika R, Kumaran, Anitha   +6 more
core   +2 more sources

Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis.

PLoS ONE, 2021
Diazoxide is the first-line drug for treating hyperinsulinism and the only pharmacological agent approved for hyperinsulinism by the Federal Drug Administration.
Xiaohong Chen, Lifang Feng, Hui Yao, Luhong Yang, Yuan Qin   +4 more
doaj   +1 more source

A combination of nifedipine and octreotide treatment in an hyperinsulinemic hypoglycemic infant. [PDF]

, 2016
PublishedResearch Support, Non-U.S. Gov'tThis is the final version of the article. Available from Galenos Publishing via the DOI in this record.Hyperinsulinemic hypoglycemia (HH) is the commonest cause of persistent hypoglycemia in the neonatal and ...
Akcurin, S, Bircan, I, Durmaz, E, Ellard, S, Flanagan, SE, Parlak, M   +5 more
core   +1 more source

Differential Pathophysiological Drivers of Susceptibility to Type 2 Diabetes and Metabolic Dysfunction–Associated Steatotic Liver Disease: Ethnic Differences in Insulin Dynamics, Whole‐Body Fat Metabolism, and Organ‐Specific Lipid Deposition

Obesity Reviews, EarlyView.
ABSTRACT Introduction This narrative review explores the epidemiological evidence and potential underlying pathophysiological defects underlying the disproportionately greater risk of Type 2 diabetes (T2D) and cardiometabolic disease in people of South Asian and African Caribbean ancestry compared with White Europeans.
Daniel J. Cuthbertson, Martin Whyte, Alex E. Henney, Uazman Alam, Louise Goff, Barbara A. Fielding, A. Margot Umpleby   +6 more
wiley   +1 more source

A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature

Frontiers in Medicine, 2023
The Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome can be potentially life-threatening. The diagnosis is sometimes difficult since the clinical manifestations may be incomplete or non-specific.
Najoua Lassoued, Najoua Lassoued, Wafa Alaya, Sondos Arfa, Mouna Korbi, Ines Lassoued, Soumaya Ben Amor, Fatma Zaouali, Zayneb Farhat, Jihen Chelly, Mohamed Habib Sfar   +10 more
doaj   +1 more source

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo [PDF]

, 2015
Epidemiological studies show that patients with type 2 diabetes (T2DM) and individuals with a diabetes-independent elevation in blood glucose have an increased risk for developing dementia, specifically dementia due to Alzheimer’s disease (AD).
Cirrito, Courtney L. Sutphen, Craft, David M. Holtzman, DeFronzo, Dunn-Meynell, Emily E. Caesar, Holtzman, Jankowsky, Liu, Marcus E. Raichle, Molly Stanley, Roh, Ronaldo Perez, Shannon L. Macauley, Steven A. Yamada, Thomas E. Mahan, Uehara   +17 more
core   +2 more sources

The Efficacy of Pharmacotherapy Intervention on Anthropometric Outcomes in Survivors of Childhood Brain Tumors: An Updated Systematic Review and Meta‐Analysis

Obesity Reviews, EarlyView.
ABSTRACT Introduction Many survivors of childhood brain tumors face long‐term adverse health outcomes like obesity. Uncertainties surround the effect of interventions to manage obesity‐related outcomes in survivors of childhood brain tumors. The goal of this updated systematic review and meta‐analysis was to provide the best estimate of the treatment ...
David Hart, Lawrence Mbuagbaw, Joseph Beyene, Marwa Akola, Sarah Burrow, M. Constantine Samaan, Lehana Thabane, Adam Fleming, Donna L. Johnston, Shahrad R. Rassekh, Laura Banfield, Russell J. de Souza   +11 more
wiley   +1 more source

Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide [PDF]

, 2001
Background: The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial KATP channel opening in myocytes. Glimepiride (Glim) is a new sulfonylurea reported to affect
Baxter, G.F., Lawrence, C.L., Maddock, H.L., Mocanu, M.M., Standen, N.B., Yellon, D.M.   +5 more
core  

Prompt Resolution of Hypoglycemia by Hepatic Transarterial Embolization for Malignant Insulinoma with Multiple Liver Metastases [PDF]

, 2014
A 45-year-old female who presented with loss of consciousness and a cold sweat was found to have a pancreatic tumor and multiple liver metastases. Laboratory studies showed marked hypoglycemia and inappropriately elevated serum insulin, C-peptide, and ...
Fujiwara, Hiroyasu, Harada, Ryo, Kanzaki, Hiromitsu, Kato, Hironari, Matsubara, Minoru, Muro, Shinichiro, Nakarai, Asuka, Nasu, Junichiro, Okada, Hiroyuki, Tanaka, Takehiro, Tsutsumi, Kouichiro, Uno, Masatoshi, Yamamoto, Kazuhide   +12 more
core   +1 more source