Results 51 to 60 of about 12,087 (179)

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, Volume 183, Issue 12, Page 3213-3233, June 2026.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells. [PDF]

PLoS ONE, 2013
Beta cells of pancreatic islets are susceptible to functional deficits and damage by hypoxia. Here we aimed to characterize such effects and to test for and pharmacological means to alleviate a negative impact of hypoxia.Rat and human pancreatic islets ...
Zuheng Ma, Noah Moruzzi, Sergiu-Bogdan Catrina, Ingrid Hals, José Oberholzer, Valdemar Grill, Anneli Björklund   +6 more
doaj   +1 more source

Effects of Mitochondrial ATP-Sensitive Potassium Channel in Rats with Acute Myocardial Infarction and Its Association with the AKT/mTOR Pathway

Anatolian Journal of Cardiology, 2023
Background: Myocardial infarction is associated with the autophagy and apoptosis of cardiomyocytes, and the protein kinase B/mammalian target of rapamycin (AKT/mTOR) pathway plays a crucial role in this mechanism.
Qian Zeng, Long-Dan Zhang, Quan-fang Chen, Wei Wang, Zhou Huang, Dong-Ling Huang, Fan Wang, Feng Yang, Jifei Nong, Jie Yang, Jincheng Zeng   +10 more
doaj   +1 more source

Diazoxide maintains human myocyte volume homeostasis during stress [PDF]

, 2012
BACKGROUND: Exposure to hypothermic hyperkalemic cardioplegia, hyposmotic stress, or metabolic inhibition results in significant animal myocyte swelling (6% to10%) and subsequent reduced contractility (10% to 20%).
Al-Dadah, Ashraf S, Damiano, Ralph J, Jr., Lawton, Jennifer S, Maffit, Sara K, Schuessler, Richard B, Sellitto, Angela D   +5 more
core   +2 more sources

Nanodiamond‐Based Quantum Sensing Reveals Changes in Endo‐Lysosomal Activity of Stimulated Cardiac Fibroblasts in a Cellular Fibrosis Model

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Quantum sensing reveals intricate patterns linking endo‐lysosomal maturation to cardiac fibrosis progression, highlighting complexity in cellular remodeling. This study investigates fibroblast‐to‐myofibroblast transition under cell aging, stiffness, and TGF‐β stimulation, comparing nanodiamond uptake, endo‐lysosomal dynamics, and free radical ...
Aldona Mzyk, Ezgi Yilmaz, Giovanni D Angelo, Kirstine Berg‐Sørensen   +3 more
wiley   +1 more source

Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus [PDF]

, 2016
Diazoxide, a well-known mitochondrial KATP channel opener with neuroprotective effects, has been proposed for the effective and safe treatment of neuroinflammation.
Andrade, Carmen, Batlle, Montserrat, Gimeno-Bayon, Javier, Mahy Gehenne, Josette Nicole, Martínez Moreno, Martín, Ortega González, Fco. Javier, Rodríguez Allué, Manuel José   +6 more
core   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Diazoxide and moderate‐intensity exercise improve skeletal muscle function by decreasing oxidants and enhancing antioxidant defenses in hypertensive male rats

Physiological Reports
High sodium intake is decisive in the incidence increase and prevalence of hypertension, which has an impact on skeletal muscle functionality. Diazoxide is an antihypertensive agent that inhibits insulin secretion and is an opener of KATP channels ...
Estefanía Bravo Sánchez, César J. Nolasco Ruíz, Mariana Gómez‐Barroso, Christian Cortés Rojo, Alain R. Rodríguez Orozco, Alfredo Saavedra Molina, Salvador Manzo Ávalos, Rocío Montoya Pérez   +7 more
doaj   +1 more source

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]

, 2017
Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe, Beneventano, Martina, Bruno, Valeria, Bucci, Domenico, Di Pietro, Paola, Liberatore, Francesca, Madonna, Michele, Mascio, Giada, Nicoletti, Ferdinando, Puliti, Alda Maria, Romano, Maria Rosaria   +10 more
core   +1 more source

Hypoglycemia Occurrence and Risk Factors in Insulin Independent Patients After Total Pancreatectomy With Islet Autotransplantation

Clinical Transplantation, Volume 40, Issue 5, May 2026.
ABSTRACT Background Total pancreatectomy with islet auto‐transplantation (TPIAT) alleviates pain and preserves islet function in patients with severe pancreatitis. Although approximately one third of recipients achieve insulin independence, spontaneous hypoglycemia has been observed in this population. Its frequency, risk factors, and management remain
Azza Hassaan, Anne Eaton, Niveditha Jagadesh, Guru Trikudanathan, Martin Freeman, Elissa Downs, Srinath Chinnakotla, David Martin, Karthik Ramanathan, Gregory J. Beilman, Melena D. Bellin   +10 more
wiley   +1 more source