Results 51 to 60 of about 6,130 (153)

Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis

open access: yesJournal of Neuroinflammation, 2011
Background Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of nontraumatic disability among young adults.
Mahy Nicole   +7 more
doaj   +1 more source

Executive Summary of the 2024 Philippine Clinical Practice Guidelines on the Diagnosis and Management of Acute Severe Blood Pressure Elevation

open access: yesThe Journal of Clinical Hypertension, Volume 28, Issue 2, February 2026.
ABSTRACT A recent survey in the Philippines, PRESYON‐4, showed increasing prevalence of hypertension from 22% in the 1990s to 37% in 2021, of which only 52% were aware of their diagnosis. While rates of treatment and adherence were 68% and 86%, respectively, the rate of BP control was low at 37%. Furthermore, there remained a high degree of unawareness
Deborah Ignacia D. Ona   +17 more
wiley   +1 more source

Congenital hyperinsulinemic hypoglycemia (HH) requiring treatment as the presenting feature of Kabuki syndrome

open access: yesClinical Case Reports, 2023
Key Clinical Message Kabuki syndrome is a congenital condition characterized by a set of facial dysmorphic features that often help the clinician to suspect the diagnosis.
Saloua Ait Souabni   +3 more
doaj   +1 more source

Oncology drug repurposing as a blueprint for Alzheimer's therapy

open access: yesAlzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract Alzheimer's disease (AD) imposes substantial personal, social, and economic burdens, yet current therapies provide only modest slowing of clinical decline. Recent approvals of amyloid‐targeting antibodies confirm target engagement but also expose the limitations of single‐target strategies in a disease shaped by interacting processes ...
Viswanath Das, Marián Hajdúch
wiley   +1 more source

Suspected congenital hyperinsulinism in a Shiba Inu dog

open access: yesJournal of Veterinary Internal Medicine, 2020
A 3‐month‐old male intact Shiba Inu dog was evaluated for a seizure disorder initially deemed idiopathic in origin. Seizure frequency remained unchanged despite therapeutic serum phenobarbital concentration and use of levetiracetam.
Simon Cook   +4 more
doaj   +1 more source

Mitochondrial ATP-Sensitive K+ Channel Opening Increased the Airway Smooth Muscle Cell Proliferation by Activating the PI3K/AKT Signaling Pathway in a Rat Model of Asthma

open access: yesCanadian Respiratory Journal, 2021
Abnormal proliferation of airway smooth muscle cells (ASMCs) leads to airway remodeling and the development of asthma. This study aimed to assess whether mitochondrial ATP-sensitive K+ (mitoKATP) channels regulated the proliferation of ASMCs by ...
Min Gao, Qinran Sun, Qingfa Liu
doaj   +1 more source

Coexisting ADAR and TSHB Mutations in an Infant With Retinal Detachment and Transient Cardiomyopathy

open access: yesCase Reports in Endocrinology, Volume 2026, Issue 1, 2026.
Background Central congenital hypothyroidism (C‐CH) due to thyroid‐stimulating hormone beta (TSHB) variants is rare and often missed by thyroid‐stimulating hormone (TSH)–based neonatal screening. Adenosine deaminase acting on RNA (ADAR)‐related Aicardi–Goutières syndrome type 6 (AGS6) is an interferonopathy with early‐onset encephalopathy.
Tamer Draidi   +5 more
wiley   +1 more source

Non‐Islet Cell Tumor Hypoglycemia Secondary to Gastrointestinal Stromal Tumor: A Rare Paraneoplastic Presentation

open access: yesCase Reports in Oncological Medicine, Volume 2026, Issue 1, 2026.
We present a rare case of non‐islet cell tumor hypoglycemia (NICTH) in a 52‐year‐old female with metastatic gastrointestinal stromal tumor (GIST). Her hypoglycemia worsened alongside her disease burden, reaching Grade 4 and mirroring the rapid progression of her cancer.
K. Elmusharaf   +5 more
wiley   +1 more source

Pulmonary hypertension occurring with diazoxide use in a preterm infant with hypoglycemia

open access: yesDrug, Healthcare and Patient Safety, 2019
Ranjit I Kylat Division of Neonatal-Perinatal Medicine and Developmental Biology, Department of Pediatrics, The University of Arizona, College of Medicine, Tucson, AZ, USA Abstract: Pharmacologic modulation to open the KATP channels with diazoxide is ...
Kylat RI
doaj  

Successful medical management of insulinoma with diazoxide for 27 years

open access: yesEndocrinology, Diabetes & Metabolism Case Reports, 2020
Despite improvements in localisation techniques and surgical advances, some patients with insulinoma will not be cured by surgery or may not be suitable for surgery. Medical management with diazoxide is an option for such cases.
Annabelle M Warren   +2 more
doaj   +1 more source

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