Results 51 to 60 of about 8,944 (181)
Obesity Reviews, Volume 27, Issue 8, August 2026.ABSTRACT Introduction This narrative review explores the epidemiological evidence and potential underlying pathophysiological defects underlying the disproportionately greater risk of Type 2 diabetes (T2D) and cardiometabolic disease in people of South Asian and African Caribbean ancestry compared with White Europeans.
Daniel J. Cuthbertson +6 more
wiley +1 more source
Preoperative treatment of benign insulinoma: diazoxide or somatostatin analogues?
, 2022 Surgery is the ideal treatment of insulinoma. However, systemic therapy may be required to prevent severe preoperative hypoglycaemia, when surgery is contraindicated, delayed or refused and in case of unresectable metastatic disease.
Gilliaux, Quentin +3 more
core +1 more source
Trisomy 13 as a risk factor for pulmonary hypertension induced by diazoxide
Annals of Pediatric CardiologyIntroduction: Diazoxide has been used globally for hyperinsulinemic hypoglycemia. However, serious adverse drug reactions, such as pulmonary hypertension (PH), are major concerns.
Kazu Ishikawa +4 more
doaj +1 more source
Ex Vivo Lung Perfusion with K(ATP) Channel Modulators Antagonize Ischemia Reperfusion Injury
Cells, 2021 Ex vivo lung perfusion (EVLP) has been implemented to increase the number of donor lungs available for transplantation. The use of K(ATP) channel modulators during EVLP experiments may protect against lung ischemia-reperfusion injury and may inhibit the ...
Stephan Arni +4 more
doaj +1 more source
Bilateral Ballismus: An Unusual Clinical Sign With an Unexpected Origin
Clinical Case Reports, Volume 14, Issue 7, July 2026.ABSTRACT The spectrum of neurologic symptoms caused by hypoglycaemia can be remarkably broad. Thus, hypoglycemia should be considered early in the diagnostic workup of neurologic symptoms, including those that may appear atypical. Prompt glucose administration can result in rapid symptom resolution, potentially preventing costly or unnecessary invasive
S. Reichert +6 more
wiley +1 more source
Diazoxide-Unresponsive Forms of Congenital Hyperinsulinism
, 2019 Congenital hyperinsulinism (HI) is defined as being “diazoxide-unresponsive” if the hypoglycemia persists despite maximum doses of diazoxide for at least five days.
Henrik Thybo Christesen +5 more
core +1 more source
Effects of diazoxide on streptozotocin induced beta cell damage via HSP70/HSP90/TLR4/AMPK signaling pathways [PDF]
, 2023 I investigated the effects of diazoxide, a mitochondrial potassium channel opener, on streptozotocin (STZ) induced pancreatic beta cell damage via the HSP70/HSP90/TLR4/AMPK signaling pathways in vitro.
Kaya, Salih Tunç
core +1 more source
Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions. [PDF]
PLoS ONE, 2016 The objective of this study was to evaluate the stability of diazoxide in extemporaneously compounded oral suspensions. Oral suspensions of diazoxide 10 mg/mL were prepared from either bulk drug or capsules dispersed in either Oral Mix or Oral Mix Sugar ...
Mihaela Friciu +3 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 14, July 2026.ABSTRACT Glioblastoma (GBM) exhibits profound metabolic plasticity and resistance to conventional therapies, partly driven by mitochondrial adaptability and stress response mechanisms. ONC212, a second‐generation imipridone, targets mitochondrial proteostasis, yet determinants of tumour sensitivity remain unclear.
Ahmet Taskesen, Ceyhan Hacioglu
wiley +1 more source
Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection [PDF]
, 2004 Background - Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial reactive oxygen species (ROS) signaling.
Wynne, A +3 more
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