Results 71 to 80 of about 8,944 (181)

ACUTE AND CHRONIC INFLUENCE OF DIAZOXIDE ON ADRENAL-REGENERATION HYPERTENSION

, 1967
The antihypertensive activity of diazoxide was evaluated in rats with regenerating adrenal glands. The drug was given chronically in the drinking fluid, and also by subcutaneous injection at two intervals during the experiment.
C. E. Hall, O. Hall, O. B. Holland
core   +1 more source

Diazoxide Attenuates Ischemic Myocardial Injury in a Porcine Model [PDF]

, 2017
Background: We hypothesized that diazoxide, a mitochondrial ATP-sensitive potassium channel opener, has cardioprotective effects during acute myocardial ischemia. Diazoxide is suggested to act through protein kinase Ce (PKC epsilon) activation.
Hannu Tuominen, Sarja, Henna, Honkanen, Hannu-Pekka, Herajarvi, Johanna, Tuominen, Hannu, Ilkka Miinalainen, Juvonen, Tatu, Tuomas Anttila, Miinalainen, Ilkka, Anttila, Vesa, Henri Haapanen, Tatu Juvonen, Caius Mustonen, Haapanen, Henri, Vesa Anttila, Anttila, Tuomas, Hannu-Pekka Honkanen, Johanna Herajärvi, Mustonen, Caius, Henna Elisa Sarja   +19 more
core   +1 more source

Suspected congenital hyperinsulinism in a Shiba Inu dog

Journal of Veterinary Internal Medicine, 2020
A 3‐month‐old male intact Shiba Inu dog was evaluated for a seizure disorder initially deemed idiopathic in origin. Seizure frequency remained unchanged despite therapeutic serum phenobarbital concentration and use of levetiracetam.
Simon Cook, Myles McKenna, Barbara Glanemann, Ranbir Sandhu, Chris Scudder   +4 more
doaj   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Hypoglycemia Occurrence and Risk Factors in Insulin Independent Patients After Total Pancreatectomy With Islet Autotransplantation

Clinical Transplantation, Volume 40, Issue 5, May 2026.
ABSTRACT Background Total pancreatectomy with islet auto‐transplantation (TPIAT) alleviates pain and preserves islet function in patients with severe pancreatitis. Although approximately one third of recipients achieve insulin independence, spontaneous hypoglycemia has been observed in this population. Its frequency, risk factors, and management remain
Azza Hassaan, Anne Eaton, Niveditha Jagadesh, Guru Trikudanathan, Martin Freeman, Elissa Downs, Srinath Chinnakotla, David Martin, Karthik Ramanathan, Gregory J. Beilman, Melena D. Bellin   +10 more
wiley   +1 more source

Relaxation of Isolated Middle Cerebral Artery Induced by Diazoxide

, 1981
The effect of diazoxide on isometric tension of goat middle cerebral arteries was investigated both under resting conditions and under contraction produced by 10^–6 Af serotonin.
C. Estrada, S. Lluch, M.V. Conde, G. Balfagón, B. Gómez   +4 more
core   +1 more source

Recurrent Hypoglycemia in Two Late‐Preterm Infants With Transitional Disorder of Glucose Mobilization—Case Series

Clinical Case Reports, Volume 14, Issue 3, March 2026.
Timeline of events. ABSTRACT Great emphasis is placed upon addressing hyperinsulinism in at‐risk infants with recurrent hypoglycemia. We report two preterm infants with recurrent nonhyperinsulinemic hypoglycemia due to transient impairment of glucose mobilization, warranting diazoxide use.
Suresh Chandran, Yu Shan Ting, Skanthakumar Abhirami, Fabian Yap   +3 more
wiley   +1 more source

Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma

Frontiers in Endocrinology
Definitive management of insulinoma is challenging as curative surgery is associated with a considerable risk of morbidity and mortality. The successful long-term use of diazoxide for patients diagnosed with insulinoma has been described, but rarely, the
Run Ting Chin, Jolene Jiayu Kiew, Khek Yu Ho, Doddabele S. Deepak   +3 more
doaj   +1 more source

Future Prospects of Imatinib in Advanced Pulmonary Hypertension Management

IUBMB Life, Volume 78, Issue 3, March 2026.
ABSTRACT Pulmonary arterial hypertension (PAH) is a severe, progressive disease characterized by elevated pulmonary arterial pressure and increased vascular resistance. This hemodynamic strain forces the right ventricle to pump against a high‐pressure system, ultimately leading to right‐sided heart failure and death.
Federica Davì, Stella Mangione, Antonella Iaconis, Tiziana Genovese, Nicla Tranchida, Salvatore Cuzzocrea   +5 more
wiley   +1 more source

Analysis of cerebrovascular action of diazoxide in conscious goats.

, 1980
The effects of diazoxide on cerebral blood flow were evaluated in unanesthetized goats under control conditions and after selective blockade of adrenergic or cholinergic receptors in cerebral vessels.
B Gómez, G Dieguez, S Lluch
core   +1 more source