Results 71 to 80 of about 12,087 (179)

Adenosine triphosphate-sensitive potassium channel Kir subunits implicated in cardioprotection by diazoxide [PDF]

, 2015
BACKGROUND: ATP-sensitive potassium (K(ATP)) channel openers provide cardioprotection in multiple models. Ion flux at an unidentified mitochondrial K(ATP) channel has been proposed as the mechanism.
Henn, Matthew C, Janjua, M. Burhan, Kanter, Evelyn M, Lawton, Jennifer S, Makepeace, Carol M, Nichols, Colin G, Schuessler, Richard B   +6 more
core   +2 more sources

Executive Summary of the 2024 Philippine Clinical Practice Guidelines on the Diagnosis and Management of Acute Severe Blood Pressure Elevation

The Journal of Clinical Hypertension, Volume 28, Issue 2, February 2026.
ABSTRACT A recent survey in the Philippines, PRESYON‐4, showed increasing prevalence of hypertension from 22% in the 1990s to 37% in 2021, of which only 52% were aware of their diagnosis. While rates of treatment and adherence were 68% and 86%, respectively, the rate of BP control was low at 37%. Furthermore, there remained a high degree of unawareness
Deborah Ignacia D. Ona, Felix Eduardo Punzalan, Raymond V. Oliva, Ma. Sergia Fatima Sucaldito, Noel Espallardo, Richard Santos, Hannah Almenario, Karl Murillo, Valentin Dones III, Elmer Jasper Llanes, Lourdes Ella Santos, Maria Cristina San Jose, Alyssa Samantha Fusingan‐Peralta, Rommel Bataclan, Maria Katrina Mata, Pauline Convocar, Aurelia Leus, Gilbert Vilela   +17 more
wiley   +1 more source

Heterozygous Insulin Receptor (INSR) Mutation Associated with Neonatal Hyperinsulinemic Hypoglycaemia and Familial Diabetes Mellitus: Case Series

JCRPE, 2020
Mutations in the insulin receptor (INSR) gene are associated with insulin resistance and hyperglycaemia. Various autosomal dominant heterozygous INSR mutations leading to hyperinsulinemic hypoglycaemia (HH) have been described in adults and children ...
Aashish Sethi, Nicola Foulds, Sarah Ehtisham, Syed Haris Ahmed, Jayne Houghton, Kevin Colclough, Mohammed Didi, Sarah E. Flanagan, Senthil Senniappan   +8 more
doaj   +1 more source

Az ATP-szenzitív káliumion-csatorna nyitók neuroprotektív hatásának vizsgálata újszülött malacban = The neuroprotective effect of ATP-sensitive potassium channel openers in piglets [PDF]

, 2006
A pályázat célja az mitokondriális ATP-szenzitív káliumcsatorna (mitoKATP) nyitók közé tartozó diazoxid direkt és indirekt neuroprotektív hatásának vizsgálata volt az újszülött malacban.
Domoki, Ferenc, Nagy, Krisztina
core  

Oncology drug repurposing as a blueprint for Alzheimer's therapy

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract Alzheimer's disease (AD) imposes substantial personal, social, and economic burdens, yet current therapies provide only modest slowing of clinical decline. Recent approvals of amyloid‐targeting antibodies confirm target engagement but also expose the limitations of single‐target strategies in a disease shaped by interacting processes ...
Viswanath Das, Marián Hajdúch
wiley   +1 more source

Oral administration of the K_ATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis

Journal of Neuroinflammation, 2011
Background Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of nontraumatic disability among young adults.
Mahy Nicole, Rodríguez Manuel J, Gimeno-Bayon Javier, Pastén-Zamorano Andrea, Mancera Pilar, Espinosa-Parrilla Juan F, Virgili Noemí, Pugliese Marco   +7 more
doaj   +1 more source

Differential sensitivity of atrial and ventricular KATP channels to metabolic inhibition [PDF]

, 2017
Objective: The aim is to compare the activation of ATP-sensitive potassium channels (KATP channels) in intact and metabolically impaired atrial and ventricular myocytes.
Baertschi, Alex J., Coppex, Fabrice, Poitry, Serge, Roatti, Angela, van Bever, Laurianne   +4 more
core  

A Multicenter Experience with Long-Acting Somatostatin Analogues in Patients with Congenital Hyperinsulinism [PDF]

, 2017
Background/Aims: Congenital hyperinsulinism (CHI) is a rare disease characterized by recurrent severe hypoglycemia. In the diffuse form of CHI, pharmacotherapy is the preferred choice of treatment.
Banerjee, Indraneel, Boot, Annemieke M., Christesen, Henrik Thybo, Empting, Susann, Mohnike, Klaus, Rasmussen, Amalie Greve, Salomon-Estebanez, Maria, Stuart, Annemarie Verrijn, van Albada, Mirjam E., van der Linde, Annelieke A. A., van der Steen, Ivo   +10 more
core   +4 more sources

Non‐Islet Cell Tumor Hypoglycemia Secondary to Gastrointestinal Stromal Tumor: A Rare Paraneoplastic Presentation

Case Reports in Oncological Medicine, Volume 2026, Issue 1, 2026.
We present a rare case of non‐islet cell tumor hypoglycemia (NICTH) in a 52‐year‐old female with metastatic gastrointestinal stromal tumor (GIST). Her hypoglycemia worsened alongside her disease burden, reaching Grade 4 and mirroring the rapid progression of her cancer.
K. Elmusharaf, H. Ismail, O. M. Fitzpatrick, C. Moloney, W. Grogan, Jose I. Mayordomo   +5 more
wiley   +1 more source

Congenital hyperinsulinemic hypoglycemia (HH) requiring treatment as the presenting feature of Kabuki syndrome

Clinical Case Reports, 2023
Key Clinical Message Kabuki syndrome is a congenital condition characterized by a set of facial dysmorphic features that often help the clinician to suspect the diagnosis.
Saloua Ait Souabni, Antoine Harvengt, Camille Legat, Philippe A. Lysy   +3 more
doaj   +1 more source