Results 61 to 70 of about 6,140 (153)
Oncology drug repurposing as a blueprint for Alzheimer's therapy
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.Abstract Alzheimer's disease (AD) imposes substantial personal, social, and economic burdens, yet current therapies provide only modest slowing of clinical decline. Recent approvals of amyloid‐targeting antibodies confirm target engagement but also expose the limitations of single‐target strategies in a disease shaped by interacting processes ...
Viswanath Das, Marián Hajdúch
wiley +1 more source
Coexisting ADAR and TSHB Mutations in an Infant With Retinal Detachment and Transient Cardiomyopathy
Case Reports in Endocrinology, Volume 2026, Issue 1, 2026.Background Central congenital hypothyroidism (C‐CH) due to thyroid‐stimulating hormone beta (TSHB) variants is rare and often missed by thyroid‐stimulating hormone (TSH)–based neonatal screening. Adenosine deaminase acting on RNA (ADAR)‐related Aicardi–Goutières syndrome type 6 (AGS6) is an interferonopathy with early‐onset encephalopathy.
Tamer Draidi +5 more
wiley +1 more source
Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma
Frontiers in EndocrinologyDefinitive management of insulinoma is challenging as curative surgery is associated with a considerable risk of morbidity and mortality. The successful long-term use of diazoxide for patients diagnosed with insulinoma has been described, but rarely, the
Run Ting Chin +3 more
doaj +1 more source
Proinsulinoma Unmasked by Intermittent Fasting: A Case of Endogenous Proinsulinaemic Hypoglycaemia
Case Reports in Endocrinology, Volume 2026, Issue 1, 2026.We report a 45‐year‐old man with recurrent fasting and post‐prandial hypoglycaemia due to a proinsulin (PI)‐secreting pancreatic neuroendocrine tumour (NET). During a supervised fast, plasma glucose fell to 1.8 mmol/L with detectable but low insulin (0.6 μU/L) and C‐peptide (range 0.3–0.6 nmol/L). These concentrations did not meet diagnostic thresholds
Aongus O’Brolchain +4 more
wiley +1 more source
Sirolimus therapy in a child with partially diazoxide-responsive hyperinsulinaemic hypoglycaemia
Endocrinology, Diabetes & Metabolism Case Reports, 2016 Hyperinsulinaemic hypoglycaemia (HH), which causes persistent neonatal hypoglycaemia, can result in neurological damage and it’s management is challenging.
Kah-Yin Loke +5 more
doaj +1 more source
Anticonvulsant Effect of Diazoxide against Dichlorvos-Induced Seizures in Mice
The Scientific World Journal, 2013 Dichlorvos, a synthetic organophosphate toxin, is used as pesticides. These toxins can be used as pesticides in farming and medicine for the devastation and/or elimination of ectoparasites of animals.
Amin Jazayeri +2 more
doaj +1 more source
Severe transient neonatal hyperinsulinism: First Peruvian case series
SAGE Open Medical Case ReportsCongenital hyperinsulinism is characterized by dysregulated insulin secretion and is the most common and severe cause of persistent hypoglycemia in pediatrics. Brain damage rates can be as high as 50% due to inadequate treatment.
Manuel André Virú-Loza +2 more
doaj +1 more source
مجله دانشگاه علوم پزشکی گرگان, 2010 Background and Objective: Until now there is no drug formulated to prevent Neuronal Loss following Brain Stroke. In this study, we compared the effects of the mitoKATP opener, diazoxide, on ultra-structural morphology changes following in cortical ...
Katebi M (PhD) +5 more
doaj
JCRPEHomozygous or compound heterozygous mutations in insulin receptor gene (INSR) lead to marked insulin resistance and hyperglycaemia in Donohue syndrome and Rabson-Mendenhall syndrome, conditions which are associated with significant morbidity early in ...
Sarah Wing-Yiu Poon +3 more
doaj +1 more source