Sirolimus therapy in a child with partially diazoxide-responsive hyperinsulinaemic hypoglycaemia
Endocrinology, Diabetes & Metabolism Case Reports, 2016 Hyperinsulinaemic hypoglycaemia (HH), which causes persistent neonatal hypoglycaemia, can result in neurological damage and it’s management is challenging.
Kah-Yin Loke +5 more
doaj +1 more source
Pulmonary hypertension, heart failure and neutropenia due to diazoxide therapy
, 2008 PubMedID: 18512033Primary persistent hyperinsulinaemic hypoglycaemia is characterised by clinical symptoms that occur when blood glucose levels drop below the normal range. Diazoxide treatment remains the mainstay of medical therapy.
Erdem S. +4 more
core +1 more source
Population Pharmacokinetics of Diazoxide in Children with Hyperinsulinemic Hypoglycemia
, 2017 <b><i>Background:</i></b> Diazoxide is the first-line treatment for pediatric hyperinsulinemic hypoglycemia (HI). This study aimed to elucidate the pharmacokinetics of diazoxide in children with HI.
Toshiaki Tanaka +6 more
core +1 more source
Diazoxide protects against doxorubicin-induced cardiotoxicity in the rat [PDF]
, 2014 Aim: Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure.
Hole, Lisa Drange +9 more
core +2 more sources
Identification of an ABCC8 variant in a kindred with transient diazoxide responsive hyperinsulinism
Endocrinology, Diabetes & Metabolism Case ReportsCongenital hyperinsulinism is a rare disorder characterized by hypoglycemia and inappropriately elevated insulin levels. The genetics of congenital hyperinsulinism is complex, with the most common cause being pathogenic variants in the ATP-sensitive ...
Ryan L Smith, Stephen I Stone
doaj +1 more source
Anticonvulsant Effect of Diazoxide against Dichlorvos-Induced Seizures in Mice
The Scientific World Journal, 2013 Dichlorvos, a synthetic organophosphate toxin, is used as pesticides. These toxins can be used as pesticides in farming and medicine for the devastation and/or elimination of ectoparasites of animals.
Amin Jazayeri +2 more
doaj +1 more source
Diazoxide inhibits intracellular calcium accumulation.
, 2013 Data points are the mean ± SEM of 30 separate cells. 100 depicts baseline Fluo-3 intensity. Drugs administered at 0 seconds. These data are representative of 3 separate studies. Tolbutamide (100 uM), diazoxide (10 uM).
Carolyn McClaskey (364455) +4 more
core +1 more source
Severe transient neonatal hyperinsulinism: First Peruvian case series
SAGE Open Medical Case ReportsCongenital hyperinsulinism is characterized by dysregulated insulin secretion and is the most common and severe cause of persistent hypoglycemia in pediatrics. Brain damage rates can be as high as 50% due to inadequate treatment.
Manuel André Virú-Loza +2 more
doaj +1 more source
Action of diazoxide on isolated vascular smooth muscle
, 1969 Diazoxide, a non-diuretic benzothiadiazlne antihypertensive agent, is thought to act directly upon the vascular smooth muscle of the resistance vessels to exert its therapeutic effects in hypertension.
Rhodes, Harold James
core +1 more source
Complications of diazoxide treatment in persistent neonatal hyperinsulinism
, 1989 SUMMARY Seven infants with persistent neonatal hyperinsulinism were treated in Dhahran Health Centre from 1983 to 1986. The insulin:glucose ratio (serum insulin concentration pmolIl) divided by the blood glucose concentration (mmolI1) ranged from 12 to ...
K B Manasra +3 more
core +1 more source