Results 91 to 100 of about 12,087 (179)

Pulmonary hypertension occurring with diazoxide use in a preterm infant with hypoglycemia

Drug, Healthcare and Patient Safety, 2019
Ranjit I Kylat Division of Neonatal-Perinatal Medicine and Developmental Biology, Department of Pediatrics, The University of Arizona, College of Medicine, Tucson, AZ, USA Abstract: Pharmacologic modulation to open the KATP channels with diazoxide is ...
Kylat RI
doaj  

Repurposed antihypertensive drugs for negative symptoms in schizophrenia: A systematic review and meta‐analysis

Psychiatry and Clinical Neurosciences, Volume 79, Issue 12, Page 784-800, December 2025.
Schizophrenia is a complex psychiatric disorder characterized by positive, negative, and general psychopathological symptoms. While antipsychotic drugs are effective for positive symptoms, they provide limited benefit for negative symptoms, which are often persistent and strongly associated with functional disability.
Thiago Carnaval, My Bui, Jesús Villoria, Dolores Rodríguez, José Manuel Menchón, Francisco Ciruela, Sebastián Videla   +6 more
wiley   +1 more source

Insulin trafficking in a glucose responsive engineered human liver cell line is regulated by the interaction of ATP-sensitive potassium channels and voltage- gated calcium channels [PDF]

, 2013
Type I diabetes is caused by the autoimmune destruction of pancreatic beta (â) cells [1]. Current treatment requires multiple daily injections of insulin to control blood glucose levels.
An, T, Castro, LM, Ch'ng, E, Elgundi, Z, Liu, GJ, Lutherborrow, M, Martin, DK, Nicholson, GM, O'Brien, B, Simpson, AM, Swan, MA, Tao, CZ, Ting, HJ, Torpy, FR, Tuch, BE   +14 more
core   +1 more source

A Deep Clinical and Biochemical Characterization of a Patient With Combined Malonic and Methylmalonic Aciduria (CMAMMA)

JIMD Reports, Volume 66, Issue 6, November 2025.
ABSTRACT Combined malonic and methylmalonic aciduria (CMAMMA) is an inborn error of metabolism caused by a deficiency in mitochondrial malonyl‐CoA synthetase, the enzyme responsible for activating malonic acid (MA) to malonyl‐CoA, a precursor of lipoic acid.
Vincenza Gragnaniello, Alfonso Galderisi, Sara Tucci, Mara Doimo, Marianna Caterino, Christian Loro, Chiara Cazzorla, Margherita Ruoppolo, Leonardo Salviati, Alberto B. Burlina   +9 more
wiley   +1 more source

ATP-Sensitive Potassium Channel-Mediated Lactate Effect on Orexin Neurons: Implications for Brain Energetics during Arousal [PDF]

, 2010
Active neurons have a high demand for energy substrate, which is thought to be mainly supplied as lactate by astrocytes. Heavy lactate dependence of neuronal activity suggests that there may be a mechanism that detects and controls lactate levels and/or ...
Hirasawa, Michiru, Parsons, Matthew P.
core   +1 more source

Sirolimus therapy in a child with partially diazoxide-responsive hyperinsulinaemic hypoglycaemia

Endocrinology, Diabetes & Metabolism Case Reports, 2016
Hyperinsulinaemic hypoglycaemia (HH), which causes persistent neonatal hypoglycaemia, can result in neurological damage and it’s management is challenging.
Kah-Yin Loke, Andrew Sng Anjian, Yvonne Lim Yijuan, Cindy Ho Wei Li, Maria Güemes, Khalid Hussain   +5 more
doaj   +1 more source

Clinical and molecular data from 61 Brazilian cases of Congenital Hyperinsulinemic Hypoglycemia [PDF]

, 2015
Objective: To study the clinical and molecular characteristics of a sample of Brazilian patients with Congenital Hyperinsulinemic Hypoglycemia (CHH).Methods: Electronic message was sent to members from Endocrinology Department-Brazilian Society of ...
Della Manna, Thais, Guerra, Gil, Liberatore, Raphael Del Roio, Martinelli Junior, Carlos Eduardo, Ramos, Priscila Manzini, Silva, Ivani Novato   +5 more
core   +3 more sources

Safety and feasibility of hyperkalemic cardioplegia with diazoxide in cardiac surgery: The Cardioplegia with Diazoxide in Cardiac Surgery TrialCentral MessagePerspective

JTCVS Open
Background: We have demonstrated cardioprotection by the adenosine triphosphate–sensitive potassium (KATP) channel opener diazoxide in multiple animal models in an effort to reduce myocardial stunning following cardiac surgery.
AlleaBelle Bradshaw, MD, Jessica B. Briscoe, MD, Lisa Fornaresio, PhD, Zyriah Robinson, BS, Michelle Carvajal Villalba, MD, Shivani Shirodkar, MBBS, MPH, Hamza Aziz, MD, Jennifer S. Lawton, MD   +7 more
doaj   +1 more source

Erythematous Papules and Plaques in an Infant Receiving Glucagon Therapy

JEADV Clinical Practice, Volume 4, Issue 5, Page 1263-1266, December 2025.
Sara Al Janahi, Alya Al‐Ali, Meera Al Adawi, Yusra S. Al Ali, Harish Bangalore   +4 more
wiley   +1 more source

Brain injury due to persistent hyperinsulinemic hypoglycemia of infancy [PDF]

, 2007
A
De Visschere, Pieter, Senepart, Maarten, Seynaeve, Patrick, Vanrietvelde, Frederik   +3 more
core   +2 more sources