Results 31 to 40 of about 6,140 (153)

The danger of diazoxide in the neonatal intensive care unit

Therapeutic Advances in Drug Safety, 2021
Background: The most common cause of persistent hypoglycemia in infancy is hyperinsulinemic hypoglycemia. When conservative measures fail, providers often use medications to treat persistent hypoglycemia.
Jay Desai, Logan Key, Alyson Swindall, Kan Gaston, Ajay J. Talati   +4 more
doaj   +1 more source

Necrotizing enterocolitis following diazoxide therapy for persistent neonatal hypoglycemia

Journal of Pediatric Surgery Case Reports, 2020
Recalcitrant neonatal hypoglycemia poses a treatment challenge for clinicians. When a patient's hypoglycemia does not respond to dextrose infusion, several medication options are available, including diazoxide(1,2).
Christina M. Theodorou, Shinjiro Hirose
doaj   +1 more source

Partial diazoxide responsiveness in a neonate with hyperinsulinism due to homozygous ABCC8 mutation

Endocrinology, Diabetes & Metabolism Case Reports, 2019
We report a case of partial diazoxide responsiveness in a child with severe congenital hyperinsulinaemic hypoglycaemia (CHI) due to a homozygous ABCC8 mutation.
Sarah Kiff, Carolyn Babb, Maria Guemes, Antonia Dastamani, Clare Gilbert, Sarah E Flanagan, Sian Ellard, John Barton, M Dattani, Pratik Shah   +9 more
doaj   +1 more source

Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis.

PLoS ONE, 2021
Diazoxide is the first-line drug for treating hyperinsulinism and the only pharmacological agent approved for hyperinsulinism by the Federal Drug Administration.
Xiaohong Chen, Lifang Feng, Hui Yao, Luhong Yang, Yuan Qin   +4 more
doaj   +1 more source

The Efficacy of Pharmacotherapy Intervention on Anthropometric Outcomes in Survivors of Childhood Brain Tumors: An Updated Systematic Review and Meta‐Analysis

Obesity Reviews, EarlyView.
ABSTRACT Introduction Many survivors of childhood brain tumors face long‐term adverse health outcomes like obesity. Uncertainties surround the effect of interventions to manage obesity‐related outcomes in survivors of childhood brain tumors. The goal of this updated systematic review and meta‐analysis was to provide the best estimate of the treatment ...
David Hart, Lawrence Mbuagbaw, Joseph Beyene, Marwa Akola, Sarah Burrow, M. Constantine Samaan, Lehana Thabane, Adam Fleming, Donna L. Johnston, Shahrad R. Rassekh, Laura Banfield, Russell J. de Souza   +11 more
wiley   +1 more source

A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature

Frontiers in Medicine, 2023
The Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome can be potentially life-threatening. The diagnosis is sometimes difficult since the clinical manifestations may be incomplete or non-specific.
Najoua Lassoued, Najoua Lassoued, Wafa Alaya, Sondos Arfa, Mouna Korbi, Ines Lassoued, Soumaya Ben Amor, Fatma Zaouali, Zayneb Farhat, Jihen Chelly, Mohamed Habib Sfar   +10 more
doaj   +1 more source

Differential Pathophysiological Drivers of Susceptibility to Type 2 Diabetes and Metabolic Dysfunction–Associated Steatotic Liver Disease: Ethnic Differences in Insulin Dynamics, Whole‐Body Fat Metabolism, and Organ‐Specific Lipid Deposition

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Introduction This narrative review explores the epidemiological evidence and potential underlying pathophysiological defects underlying the disproportionately greater risk of Type 2 diabetes (T2D) and cardiometabolic disease in people of South Asian and African Caribbean ancestry compared with White Europeans.
Daniel J. Cuthbertson, Martin Whyte, Alex E. Henney, Uazman Alam, Louise Goff, Barbara A. Fielding, A. Margot Umpleby   +6 more
wiley   +1 more source

Thirst and blood pressure regulation in a novel angiotensin II receptor type 1a knockout rat

Physiological Reports, Volume 14, Issue 15, August 2026.
Regulation of arterial blood pressure (ABP) is largely preserved in angiotensin II receptor 1a knock‐out (Agtr1a−/−) rats. However, deletion of Agtr1a attenuates thirst in response to AngII and hypotension but not intracellular dehydration. Abstract Angiotensin II (AngII) plays a pivotal role in body fluid balance through AngII type 1 receptors (Agtr1)
Caroline B. Ferreira, Sean D. Stocker
wiley   +1 more source

Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells. [PDF]

PLoS ONE, 2013
Beta cells of pancreatic islets are susceptible to functional deficits and damage by hypoxia. Here we aimed to characterize such effects and to test for and pharmacological means to alleviate a negative impact of hypoxia.Rat and human pancreatic islets ...
Zuheng Ma, Noah Moruzzi, Sergiu-Bogdan Catrina, Ingrid Hals, José Oberholzer, Valdemar Grill, Anneli Björklund   +6 more
doaj   +1 more source

Effects of Mitochondrial ATP-Sensitive Potassium Channel in Rats with Acute Myocardial Infarction and Its Association with the AKT/mTOR Pathway

Anatolian Journal of Cardiology, 2023
Background: Myocardial infarction is associated with the autophagy and apoptosis of cardiomyocytes, and the protein kinase B/mammalian target of rapamycin (AKT/mTOR) pathway plays a crucial role in this mechanism.
Qian Zeng, Long-Dan Zhang, Quan-fang Chen, Wei Wang, Zhou Huang, Dong-Ling Huang, Fan Wang, Feng Yang, Jifei Nong, Jie Yang, Jincheng Zeng   +10 more
doaj   +1 more source