Results 31 to 40 of about 8,944 (181)

Adverse Effects Associated with Diazoxide Use in Neonates [PDF]

, 2022
Introduction: Diazoxide is the first-line treatment used to manage infants and children with hypoglycemia secondary to hyperinsulinemic hypoglycemia (HH), after initial stabilization of blood glucose.
Graber, Evan, Kushnir, Alla, Hunter, Krystal, Begun, Zoe   +3 more
core   +1 more source

The mitochondrial K-ATP channel opener diazoxide upregulates STIM1 and Orai1 via ROS and the MAPK pathway in adult rat cardiomyocytes

Cell & Bioscience, 2020
Background Openers of mitochondrial adenosine triphosphate-dependent potassium (mKATP) channels like diazoxide increase reactive oxygen species (ROS) production in cardiac cells and reduce Ca2+ elevations produced by ischemia–reperfusion, protecting the ...
Joice T. Gavali, Elba D. Carrillo, María C. García, Jorge A. Sánchez   +3 more
doaj   +1 more source

Effect Of Diazoxide on Friedreich Ataxia Models [PDF]

, 2018
Friedreich ataxia (FRDA) is an inherited recessive disorder caused by a deficiency in the mitochondrial protein frataxin. There is currently no effective treatment for FRDA available, especially for neurological deficits.
Vito Porcelli, Porcelli, Vito, Paradies, E, Taroni, Franco, Virmouni, SA, Porcelli, V, Carlo M T Marobbio, Merla, Giuseppe, Vozza, Angelo, Pook, MA, Eleonora Paradies, Nunzio Denora, Al-Mahdawi, Sahar, Mara Perrone, Sara Anjomani Virmouni, Taroni, F, Antonella Santoro, Valentina L Villalobos Coa, Palmieri, L, Perrone, Mara, Marobbio, Carlo, Luigi Palmieri, Mark A Pook, Marobbio, CMT, Santoro, A, Al-Mahdawi, S, Khoo, M, Denora, N, Franco Taroni, Denora, Nunzio, Vozza, A, Perrone, M, Paradies, Eleonora, Pook, Mark A, Sahar Al-Mahdawi, Santoro, Antonella, Villalobos Coa, Valentina L, Coa, VLV, Merla, G, Anjomani Virmouni, Sara, Giuseppe Merla, Palmieri, Luigi, Khoo, Mee, Angelo Vozza, Mee Khoo   +44 more
core   +2 more sources

Diazoxide protects myocardial mitochondria, metabolism, and function during cardiac surgery: A double-blind randomized feasibility study of diazoxide-supplemented cardioplegia [PDF]

, 2009
ObjectivesThe study was designed to assess whether diazoxide-mediated cardioprotection might be used in human subjects during cardiac surgery.MethodsForty patients undergoing coronary artery bypass grafting were randomized to receive intermittent warm ...
Kajor, Maciej, Szurlej, Dariusz, Domaradzki, Wojciech, Biernat, Jolanta, Gołba, Krzysztof S., Woś, Stanisław, Malinowski, Marcin, Bończyk, Andrzej, Deja, Marek A., Hudziak, Damian, Lebda-Wyborny, Tomasz   +10 more
core   +1 more source

Diazoxide and Exercise Enhance Muscle Contraction during Obesity by Decreasing ROS Levels, Lipid Peroxidation, and Improving Glutathione Redox Status

Antioxidants, 2020
Obesity causes insulin resistance and hyperinsulinemia which causes skeletal muscle dysfunction resulting in a decrease in contraction force and a reduced capacity to avoid fatigue, which overall, causes an increase in oxidative stress.
Mariana Gómez-Barroso, Koré M. Moreno-Calderón, Elizabeth Sánchez-Duarte, Christian Cortés-Rojo, Alfredo Saavedra-Molina, Alain R. Rodríguez-Orozco, Rocío Montoya-Pérez   +6 more
doaj   +1 more source

The danger of diazoxide in the neonatal intensive care unit

Therapeutic Advances in Drug Safety, 2021
Background: The most common cause of persistent hypoglycemia in infancy is hyperinsulinemic hypoglycemia. When conservative measures fail, providers often use medications to treat persistent hypoglycemia.
Jay Desai, Logan Key, Alyson Swindall, Kan Gaston, Ajay J. Talati   +4 more
doaj   +1 more source

Combined Effects of Diazoxide and Moderate-Intensity Exercise on the Restoration of Redox Balance Post-Fatigue in Fast- and Slow-Twitch Skeletal Muscles of Hypertensive Rats

Biology
Muscle fatigue, defined as a decline in force generation, is closely linked to redox imbalance—a condition exacerbated by oxidative stress in hypertension. This study investigated the effects of diazoxide administration and moderate-intensity exercise on
Estefanía Bravo-Sánchez, César J. Nolasco-Ruiz, Sarai Sánchez-Duarte, Mariana Gómez-Barroso, Manuel Alejandro Vargas-Vargas, Christian Cortés-Rojo, Salvador Manzo-Ávalos, Elizabeth Sánchez-Duarte, Alain Raimundo Rodríguez-Orozco, Alfredo Saavedra-Molina, Rocío Montoya-Pérez   +10 more
doaj   +1 more source

Partial diazoxide responsiveness in a neonate with hyperinsulinism due to homozygous ABCC8 mutation

Endocrinology, Diabetes & Metabolism Case Reports, 2019
We report a case of partial diazoxide responsiveness in a child with severe congenital hyperinsulinaemic hypoglycaemia (CHI) due to a homozygous ABCC8 mutation.
Sarah Kiff, Carolyn Babb, Maria Guemes, Antonia Dastamani, Clare Gilbert, Sarah E Flanagan, Sian Ellard, John Barton, M Dattani, Pratik Shah   +9 more
doaj   +1 more source

A New Case of Lethal Congenital Contracture Syndrome Type 3 With Hyperinsulinism and Optic Atrophy

Clinical Genetics, EarlyView.
PIP5K1C‐related lethal congenital contracture syndrome with hyperinsulinism and optic atrophy. ABSTRACT Lethal congenital contracture syndrome 3 (LCCS3, MIM #611369) is a rare autosomal recessive neuromuscular disorder caused by biallelic loss‐of‐function (LOF) variants in PIP5K1C, reported in only two families to date.
Tameemi Abdalla Moady, Hadar Hulin Ma'ayan, Michal Cohen, Karin Weiss   +3 more
wiley   +1 more source

Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis.

PLoS ONE, 2021
Diazoxide is the first-line drug for treating hyperinsulinism and the only pharmacological agent approved for hyperinsulinism by the Federal Drug Administration.
Xiaohong Chen, Lifang Feng, Hui Yao, Luhong Yang, Yuan Qin   +4 more
doaj   +1 more source