Results 21 to 30 of about 6,130 (153)
Frontiers in Molecular Biosciences, 2023 Background: Diazoxide is a selective mitochondrial-sensitive potassium channel opening agent that has a definite effect on reducing myocardial ischemia/reperfusion injury (MIRI).
Cen Xiang +7 more
doaj +1 more source
Exceptional diazoxide sensitivity in hyperinsulinaemic hypoglycaemia due to a novel HNF4A mutation
Endocrinology, Diabetes & Metabolism Case Reports, 2019 Diazoxide is the first-line treatment for patients with hyperinsulinaemic hypoglycaemia (HH). Approximately 50% of patients with HH are diazoxide resistant.
Ved Bhushan Arya +4 more
doaj +1 more source
Biology, 2022 Obesity is a chronic disease that impairs skeletal muscle function, affects the ability to contract, and promotes the development of fatigue. For this reason, the study of treatments that seek to reduce the harmful effects of obesity on muscle tissue has
Mariana Gómez-Barroso +7 more
doaj +1 more source
K(ATP) channel opener diazoxide prevents neurodegeneration: a new mechanism of action via antioxidative pathway activation. [PDF]
PLoS ONE, 2013 Pharmacological modulation of ATP-sensitive potassium channels has become a promising new therapeutic approach for the treatment of neurodegenerative diseases due to their role in mitochondrial and cellular protection.
Noemí Virgili +6 more
doaj +1 more source
Diazoxide for Neonatal Hyperinsulinemic Hypoglycemia and Pulmonary Hypertension
Children, 2022 Hypoglycemia in neonates is associated with long-term neurodevelopmental effects. Hyperinsulinemic hypoglycemia (HH) is the most common cause of persistent hypoglycemia in neonatal intensive care units.
Shoshana Newman-Lindsay +2 more
doaj +1 more source
Hypoglycemia Occurrence and Risk Factors in Insulin Independent Patients After Total Pancreatectomy With Islet Autotransplantation. [PDF]
Clin TransplantABSTRACT Background Total pancreatectomy with islet auto‐transplantation (TPIAT) alleviates pain and preserves islet function in patients with severe pancreatitis. Although approximately one third of recipients achieve insulin independence, spontaneous hypoglycemia has been observed in this population. Its frequency, risk factors, and management remain
Hassaan A +10 more
europepmc +2 more sources
Cell & Bioscience, 2020 Background Openers of mitochondrial adenosine triphosphate-dependent potassium (mKATP) channels like diazoxide increase reactive oxygen species (ROS) production in cardiac cells and reduce Ca2+ elevations produced by ischemia–reperfusion, protecting the ...
Joice T. Gavali +3 more
doaj +1 more source
Diazoxide promotes oligodendrocyte precursor cell proliferation and myelination. [PDF]
PLoS ONE, 2010 Several clinical conditions are associated with white matter injury, including periventricular white matter injury (PWMI), which is a form of brain injury sustained by preterm infants.
Birgit Fogal +4 more
doaj +1 more source
Antioxidants, 2020 Obesity causes insulin resistance and hyperinsulinemia which causes skeletal muscle dysfunction resulting in a decrease in contraction force and a reduced capacity to avoid fatigue, which overall, causes an increase in oxidative stress.
Mariana Gómez-Barroso +6 more
doaj +1 more source
The danger of diazoxide in the neonatal intensive care unit
Therapeutic Advances in Drug Safety, 2021 Background: The most common cause of persistent hypoglycemia in infancy is hyperinsulinemic hypoglycemia. When conservative measures fail, providers often use medications to treat persistent hypoglycemia.
Jay Desai +4 more
doaj +1 more source