Results 21 to 30 of about 8,944 (181)

Successful medical management of insulinoma with diazoxide for 27 years [PDF]

Endocrinology, Diabetes & Metabolism Case Reports, 2020
Despite improvements in localisation techniques and surgical advances, some patients with insulinoma will not be cured by surgery or may not be suitable for surgery. Medical management with diazoxide is an option for such cases.
Annabelle M Warren, Duncan J Topliss, Peter Shane Hamblin   +2 more
doaj   +2 more sources

Clinical Report and Genetic Analysis of a Patient With Congenital Hyperinsulinism Hyperammonemia Caused by a Novel Missense Mutation in the Structural Domain of the Isoform of the GLUD1 Gene. [PDF]

Clin Case Rep
This patient was admitted to the hospital 43 h after birth with convulsions and hypoglycemia, presenting as recurrent refractory hypoglycemia that was difficult to control with conventional medication. Whole exome sequencing detected the GLUD1 (NM_005271.3:c.1495G>T, p.Gly499Cys) variant, which was a de novo variant in the patient and was not detected ...
Li T, Liu T, Li L, Liu Y, Zhang Q, Cheng X, Li Z.   +6 more
europepmc   +2 more sources

Development and clinical application of a stability-indicating chromatography technique for the quantification of diazoxide

Heliyon, 2023
Diazoxide is a potential candidate for the treatment of transitional hypoglycaemia in infants. A clinical trial is currently underway to investigate whether low-dose oral diazoxide is beneficial for severe or recurrent transitional neonatal hypoglycaemia
Trusha J. Purohit, Don Laing, Christopher JD. McKinlay, Jane M. Alsweiler, Sara M. Hanning   +4 more
doaj   +1 more source

Diazoxide is a powerful cardioprotectant but is not feasible in a realistic infarct scenario

Frontiers in Cardiovascular Medicine, 2023
IntroductionDiazoxide is a powerful cardioprotective agent that activates mitochondrial ATP-dependent K-channels and stimulates mitochondrial respiration.
Petra Kleinbongard, Helmut Lieder, Andreas Skyschally, Gerd Heusch   +3 more
doaj   +1 more source

Thirst and blood pressure regulation in a novel angiotensin II receptor type 1a knockout rat. [PDF]

Physiol Rep
Regulation of arterial blood pressure (ABP) is largely preserved in angiotensin II receptor 1a knock‐out (Agtr1a−/−) rats. However, deletion of Agtr1a attenuates thirst in response to AngII and hypotension but not intracellular dehydration. Abstract Angiotensin II (AngII) plays a pivotal role in body fluid balance through AngII type 1 receptors (Agtr1)
Ferreira CB, Stocker SD.
europepmc   +2 more sources

Genomic Evidence on Antihypertensive Drug Targets and Oral Disease Outcomes. [PDF]

J Periodontal Res
Key Findings Drug‐target Mendelian randomization showed little evidence that genetically proxied on‐target pharmacological actions of most antihypertensive drug classes were associated with chronic periodontitis or dental caries. The diazoxide–periodontitis association requires cautious interpretation, given possible residual pleiotropy at KCNJ11 and ...
Puzhakkara Chennas A, Leiva-Escobar I, Reckelkamm SL, Holtfreter B, Kocher T, Baumeister SE, Nolde M, Alayash Z.   +7 more
europepmc   +2 more sources

Diazoxide Post-conditioning Activates the HIF-1/HRE Pathway to Induce Myocardial Protection in Hypoxic/Reoxygenated Cardiomyocytes

Frontiers in Cardiovascular Medicine, 2021
Background: Previous studies have shown that diazoxide can protect against myocardial ischemia-reperfusion injury (MIRI). The intranuclear hypoxia-inducible factor-1 (HIF-1)/hypoxia-response element (HRE) pathway has been shown to withstand cellular ...
Xi-Yuan Chen, Xi-Yuan Chen, Jia-Qi Wang, Si-Jing Cheng, Yan Wang, Meng-Yuan Deng, Tian Yu, Hai-Ying Wang, Wen-Jing Zhou, Wen-Jing Zhou   +9 more
doaj   +1 more source

Kir1.1 and SUR1 are not implicated as subunits of an adenosine triphosphate-sensitive potassium channel involved in diazoxide cardioprotectionCentral MessagePerspective

JTCVS Open, 2023
Objective: The adenosine triphosphate-sensitive potassium channel opener diazoxide mimics ischemic preconditioning and is cardioprotective. Clarification of diazoxide's site and mechanism of action could lead to targeted pharmacologic therapies for ...
Jie Wang, MD, Kyriakos Papanicolaou, PhD, Robert Tryon, PhD, Janelle Sangalang, BA, Ben Salazar, BS, Alejandro Suarez-Pierre, MD, Jie Dong, MD, Anson Lee, BS, BA, Emily Larson, BS, Sari Holmes, PhD, Brian O’Rourke, PhD, Colin Nichols, PhD, Jennifer Lawton, MD   +12 more
doaj   +1 more source

Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs [PDF]

, 1999
Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
David W. Busija, Perciaccante, J. V., Ferenc Domoki, James V. Perciaccante, Domoki, Ferenc, Bari, Ferenc, Ferenc Bari, Roland Veltkamp, Veltkamp, R.   +8 more
core   +2 more sources

Evaluation of spasmolytic effects of naringenin on ileum contraction and intestinal charcoal meal transit: Involvement of ATP-sensitive K+ channels [PDF]

Journal of HerbMed Pharmacology, 2022
Introduction: Naringenin is a flavonoid constituent of many herbal plants, including citreous fruits. Biological studies have suggested various therapeutic effects for naringenin, including protective effects on gastrointestinal (GI) motility.
Hassan Sadraei, Maedeh Ghasemi, Salman Saranji   +2 more
doaj   +1 more source