Results 91 to 100 of about 3,949,426 (332)

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Prognostic determinants of hearing outcomes in children with congenital cytomegalovirus infection [PDF]

, 2022
Ta‐Hsuan Lo, Pei‐Hsuan Lin, Wei‐Chung Hsu, Po‐Nien Tsao, Tien‐Chen Liu, Tzong‐Hann Yang, Chuan‐Jen Hsu, Li‐Min Huang, Chun‐Yi Lu, Chen‐Chi Wu   +9 more
openalex   +1 more source

Machine Learning‐Assisted Infectious Disease Detection in Low‐Income Areas: Toward Rapid Triage of Dengue and Zika Virus Using Open‐Source Hardware

Advanced Intelligent Discovery, EarlyView.
This study introduces an affordable machine learning platform for simultaneous dengue and zika detection using fluorine‐doped tin oxide thin films modified with gold nanoparticles and DNA aptamers. Designed for low‐cost, hardware‐limited devices (< $25), the model achieves 95.3% accuracy and uses only 9.4 kB of RAM, demonstrating viability for resource‐
Marina Ribeiro Batistuti Sawazaki, Bassam Bachour Junior, Marcelo Mulato, José Ilton de Oliveira Filho   +3 more
wiley   +1 more source

The burden of congenital rubella syndrome in the Philippines: results from a retrospective assessment

Western Pacific Surveillance and Response, 2017
Introduction: In line with the regional aim of eliminating rubella and congenital rubella syndrome (CRS), phased introduction of rubella-containing vaccines (RCV) in the Philippines’ routine immunization programme began in 2010.
Anna Lena Lopez, Peter Francis Raguindin, Jose Jonas del Rosario, Ramon Najarro, Eleanor Du, Josephine Aldaba, Aida Salonga, Andrea Kristina Monzon-Pajarillo, Alvina Pauline Santiago, Alan Ou, Maria Joyce Ducusin   +10 more
doaj   +1 more source

Factor XIII Supplementation in Postpartum Hemorrhage: From Biological Rationale to Clinical Implementation

American Journal of Hematology, EarlyView.
ABSTRACT Postpartum hemorrhage (PPH) remains the leading cause of preventable maternal mortality despite standard interventions. Recent fibrinogen trials failed to improve outcomes, prompting interest in coagulation factor XIII (FXIII). FXIII functions as “molecular cement,” cross‐linking fibrin and stabilizing clots.
Jeremy W. Jacobs, Elizabeth A. Abels, Brian D. Adkins, Garrett S. Booth, Victoria Costa, Sheharyar Raza, Michelle Simon, Jennifer S. Woo, Allison P. Wheeler   +8 more
wiley   +1 more source

The effect of valacyclovir on secondary prevention of congenital cytomegalovirus infection, following primary maternal infection acquired periconceptionally or in the first trimester of pregnancy. An individual patient data meta-analysis [PDF]

, 2023
Christos Chatzakis, Karen Shahar-Nissan, Valentine Faure‐Bardon, Olivier Picone, Eran Hadar, Jacob Amir, Charles Egloff, Alexandre Vivanti, Alexandros Sotiriadis, Marianne Leruez‐Ville, Y. Ville   +10 more
openalex   +1 more source

Vital Signs: Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018

MMWR. Morbidity and mortality weekly report, 2018
Introduction Zika virus infection during pregnancy causes serious birth defects and might be associated with neurodevelopmental abnormalities in children.
Marion E. Rice, R. Galang, Nicole M Roth, S. Ellington, C. Moore, Miguel Valencia-Prado, Esther M Ellis, A. Tufa, Livinson A. Taulung, Julia M. Alfred, J. Pérez-Padilla, Camille Delgado-López, S. Zaki, Sarah Reagan‐Steiner, J. Bhatnagar, John F. Nahabedian, Megan R. Reynolds, M. Yeargin-Allsopp, Laura J. Viens, Samantha M. Olson, Abbey M. Jones, Madelyn A. Baez-Santiago, Philip Oppong-Twene, Kelley VanMaldeghem, E. Simon, Jazmyn T Moore, K. Polen, Braeanna Hillman, Ruta Ropeti, L. Nieves-Ferrer, Mariam Marcano-Huertas, Carolee Masao, Edlen Anzures, R. L. Hansen, Stephany I. Pérez-Gonzalez, C. P. Espinet-Crespo, Mildred Luciano-Román, C. Shapiro-Mendoza, S. Gilboa, M. Honein   +39 more
semanticscholar   +1 more source

Descriptive Epidemiology From the Myhre Syndrome Foundation Registry: The Value of Self‐Reported Data

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is an ultrarare genetic disease characterized by short stature, distinct craniofacial features, cardiovascular and respiratory fibrosis and stenosis, neurodevelopmental delays, autism, intellectual disability, and hearing loss. The natural history of Myhre syndrome is still not fully understood due to a small patient population ...
Mary K. Young, Armelle Pindon, Maggie R. Brand, Kate Wears, Katherine H. Young, Alyssa Mendel, Michael J. Lyons   +6 more
wiley   +1 more source

Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle, Sara M. Sarasua, Tracy Lowe, Christopher L. Farrell, Luigi Boccuto, Charles Schwartz, Anthony E. Pegg, Angela Peron, Victor Faundes, Mythily Ganapathi, Wendy K. Chung, Alban Ziegler, Floris Hofstede, Clément Prouteau, Katharina Steindl, Colleen Olson, Orrin Devinsky, Teresa L. Mastracci, Robert A. Casero Jr., Tracy Murray Stewart, Susan Gilmour, Teri Koerner, Mary Jo Kutler, Surender Rajasekaran, Julianne Michael, André S. Bachmann, Caleb P. Bupp   +26 more
wiley   +1 more source

Zika Virus Infection in Pregnancy: Advanced Diagnostic Approaches in Dengue-Naive and Dengue-Experienced Pregnant Women and Possible Implication for Cross-Reactivity and Cross-Protection

Microorganisms, 2019
Zika virus (ZIKV) infection has been linked to congenital defects in fetuses and infants, as exemplified by the microcephaly epidemic in Brazil. Given the overlapping presence of Dengue virus (DENV) in the majority of ZIKV epidemic regions, advanced ...
Maurizio Zavattoni, Francesca Rovida, Elena Percivalle, Irene Cassaniti, Antonella Sarasini, Alessia Arossa, Beatrice Tassis, Lina Bollani, Giuseppina Lombardi, Simona Orcesi, Fausto Baldanti   +10 more
doaj   +1 more source