Results 111 to 120 of about 3,875,802 (326)

A Computational Framework for Atrioventricular Valve Modeling using Open-Source Software [PDF]

arXiv, 2022
Atrioventricular valve regurgitation is a significant cause of morbidity and mortality in patients with acquired and congenital cardiac valve disease. Image-derived computational modeling of atrioventricular valves has advanced substantially over the last decade and holds particular promise to inform valve repair in small and heterogeneous populations ...
arxiv  

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Genotype distribution, viral load and clinical characteristics of infants with postnatal or congenital cytomegalovirus infection. [PDF]

PLoS ONE, 2014
BACKGROUND:Congenital cytomegalovirus infection is a leading cause of long-term sequelae. Cytomegalovirus is also frequently transmitted to preterm infants postnatally, but these infections are mostly asymptomatic.
Joppe Nijman, Femke S Mandemaker, Malgorzata A Verboon-Maciolek, Susan C Aitken, Anton M van Loon, Linda S de Vries, Rob Schuurman   +6 more
doaj   +1 more source

Evaluation of cinematic volume rendering open-source and commercial solutions for the exploration of congenital heart data [PDF]

arXiv, 2023
Detailed anatomical information is essential to optimize medical decisions for surgical and pre-operative planning in patients with congenital heart disease. The visualization techniques commonly used in clinical routine for the exploration of complex cardiac data are based on multi-planar reformations, maximum intensity projection, and volume ...
arxiv  

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Congenital anomalies from a physics perspective. The key role of "manufacturing" volatility [PDF]

, 2019
Genetic and environmental factors are traditionally seen as the sole causes of congenital anomalies. In this paper we introduce a third possible cause, namely random "manufacturing" discrepancies with respect to ``design'' values. A clear way to demonstrate the existence of this component is to ``shut'' the two others and to see whether or not there is
arxiv   +1 more source

Episodic vestibular symptoms in children with a congenital cytomegalovirus infection [PDF]

, 2019
Objective: Congenital cytomegalovirus (cCMV) infection is the most common non-genetic cause of sensorineural hearing loss in children. Although cCMV-induced vestibular loss is demonstrated in several studies, the occurrence of vertigo has been described ...
Dhondt, Cleo, Dhooge, Ingeborg, Maes, Leen, Oostra, Anna   +3 more
core   +1 more source

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Vital Signs: Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018

MMWR. Morbidity and mortality weekly report, 2018
Introduction Zika virus infection during pregnancy causes serious birth defects and might be associated with neurodevelopmental abnormalities in children.
Marion E. Rice, R. Galang, Nicole M Roth, S. Ellington, C. Moore, Miguel Valencia-Prado, Esther M Ellis, A. Tufa, Livinson A. Taulung, Julia M. Alfred, Janice Pérez-Padilla, Camille Delgado-López, S. Zaki, Sarah Reagan‐Steiner, J. Bhatnagar, John F. Nahabedian, Megan R. Reynolds, M. Yeargin-Allsopp, Laura J. Viens, Samantha M. Olson, Abbey M. Jones, Madelyn A. Baez-Santiago, Philip Oppong-Twene, Kelley VanMaldeghem, E. Simon, Jazmyn T Moore, K. Polen, Braeanna Hillman, Ruta Ropeti, L. Nieves-Ferrer, Mariam Marcano-Huertas, Carolee Masao, Edlen Anzures, R. L. Hansen, Stephany I. Pérez-Gonzalez, C. P. Espinet-Crespo, Mildred Luciano-Román, C. Shapiro-Mendoza, S. Gilboa, M. Honein   +39 more
semanticscholar   +1 more source

Travel-Associated Zika Virus Disease Acquired in the Americas Through February 2016 [PDF]

, 2016
BACKGROUND: Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. OBJECTIVE: To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas ...
Asgeirsson, Hilmir, Barbre, Kira A., Caumes, Eric, Chen, Lin H., et al., Genderen, Perry J.Jl van, Goorhulis, Abraham, Grobusch, Martin P., Hagmann, Stefan H., Hamer, Davidson, Kozarsky, Phyllis E., Molina, Israel, Schlagenhauf, Patricia   +12 more
core   +1 more source