Results 51 to 60 of about 3,949,426 (332)

Cytomegalovirus Infection in Infants: A Case Series on Varied Clinical Manifestations

Journal of Clinical and Diagnostic Research
Cytomegalovirus (CMV) is a common cause of congenital infection, presenting a wide spectrum of clinical manifestations and varying grades of severity.
Caroline D Shira, Emjaj Rahman
doaj   +1 more source

From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review

Children, 2022
Congenital infections represent a challenging and varied clinical scenario in which the brain is frequently involved. Therefore, fetal and neonatal neuro-imaging plays a pivotal role in reaching an accurate diagnosis and in predicting the clinical ...
Giulia Lucignani, Alessia Guarnera, Maria Camilla Rossi-Espagnet, Giulia Moltoni, Amanda Antonelli, Lorenzo Figà Talamanca, Chiara Carducci, Francesca Ippolita Calo Carducci, Antonio Napolitano, Carlo Gandolfo, Francesca Campi, Cinzia Auriti, Cecilia Parazzini, Daniela Longo   +13 more
doaj   +1 more source

A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig Cytomegalovirus

PLoS Pathogens, 2016
In human cytomegalovirus (HCMV), tropism to epithelial and endothelial cells is dependent upon a pentameric complex (PC). Given the structure of the placenta, the PC is potentially an important neutralizing antibody target antigen against congenital ...
Stewart M Coleman, K. Y. Choi, M. Root, A. McGregor   +3 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Congenital Chylothorax with Cytomegalovirus Positivity: An Etiological Dilemma in a Neonate with Non-Immune Hydrops Fetalis

Indian Pediatrics Case Reports, 2023
Background: Nonimmune hydrops fetalis (NIHF) due to congenital chylothorax (CC) is rare and is usually associated with high mortality. Chylothorax complicated with congenital cytomegalovirus (CMV) infection is extremely rare and the management becomes ...
Yash Jain, Shivani Jain, Jenisha Jain, Minakshi Sharma   +3 more
doaj   +1 more source

Prevalence and clinical aspects of CMV congenital Infection in a low-income population

Virology Journal, 2016
BackgroundCMV is the most common cause of congenital infection in the whole world (0.2 to 2.2 %). That infection may be symptomatic or asymptomatic at birth and, although asymptomatic cases at birth are more common, some children may develop late ...
L. J. Marin, Emanuelle Santos de Carvalho Cardoso, Sandra Mara Bispo Sousa, Luciana Debortoli de Carvalho, M. F. Marques Filho, M. Raiol, S. Gadelha   +6 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Persistent Leukoencephalopathy Following H1N1 Infection Associated With a Novel MYRF Variant (p.Gly735Asp)

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu, Leiyun Huang, Wan Zhu, Min Peng, Qiang Gong, Jing Qian   +5 more
wiley   +1 more source

Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro

Viruses, 2022
Although placental small extracellular vesicles (sEVs) are extensively studied in the context of pregnancy, little is known about their role during viral congenital infection, especially at the beginning of pregnancy.
Mathilde Bergamelli, Hélène Martin, Yann Aubert, Jean-Michel Mansuy, Marlène Marcellin, Odile Burlet-Schiltz, Ilse Hurbain, Graça Raposo, Jacques Izopet, Thierry Fournier, Alexandra Benchoua, Mélinda Bénard, Marion Groussolles, Géraldine Cartron, Yann Tanguy Le Gac, Nathalie Moinard, Gisela D’Angelo, Cécile E. Malnou   +17 more
doaj   +1 more source

The Case of a 28‐Year‐Old Woman With Medically Refractory Focal Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We present the case of a 28‐year‐old right‐handed woman with medically refractory focal epilepsy. Her seizure semiology and electroencephalography (EEG) indicated a seizure onset zone in the right central‐parietal area. However, both MRI and PET scans were unremarkable, showing no focal lesions or areas of altered metabolism.
Rishi Sharma, Ilo Leppik, Thomas Henry, Thaddeus Walczak, Sima Patel, Robert McGovern   +5 more
wiley   +1 more source