Results 11 to 20 of about 29,179 (198)

Drug-Induced QT Prolongation as a Result of an Escitalopram Overdose in a Patient with Previously Undiagnosed Congenital Long QT Syndrome [PDF]

Case Reports in Medicine, 2014
We present a case of drug-induced QT prolongation caused by an escitalopram overdose in a patient with previously undiagnosed congenital LQTS. A 15-year-old Caucasian female presented following a suicide attempt via an escitalopram overdose.
Paul Singh, J. Martin Maldonado-Duran
doaj   +2 more sources

Utility of Provocative Testing in the Diagnosis and Genotyping of Congenital Long QT Syndrome: A Systematic Review and Meta-Analysis. [PDF]

J Am Heart Assoc, 2022
Background Diagnosis is particularly challenging in concealed or asymptomatic long QT syndrome (LQTS). Provocative testing, unmasking the characterization of LQTS, is a promising alternative method for the diagnosis of LQTS, but without uniform standards.
Yang Y, Lv TT, Li SY, Liu P, Gao QG, Zhang P, Zhang P.   +6 more
europepmc   +2 more sources

MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes [PDF]

Cardiovascular Research, 2020
Aims In long QT syndrome (LQTS) patients, modifier genes modulate the arrhythmic risk associated with a disease-causing mutation. Their recognition can improve risk stratification and clinical management, but their discovery represents a challenge.
Yee-Ki Lee, Luca Sala, Manuela Mura, Marcella Rocchetti, Matteo Pedrazzini, Xinru Ran, Timothy Shin Heng Mak, Lia Crotti, Pak C. Sham, Eleonora Torre, Antonio Zaza, Peter J. Schwartz, Hung‐Fat Tse, Massimiliano Gnecchi   +13 more
openalex   +2 more sources

Congenital long QT syndrome in children [PDF]

Medicinski Podmladak, 2016
Long QT syndrome (LQTS) is a cardiac repolarization disorder characterized by prolonged QT interval on the electrocardiogram (ECG) and increased propensity to ventricular tachyarrhythmias and cardiac events.
Cerović Ivana, Košutić Jovan
doaj   +3 more sources

“Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and Review [PDF]

Clinical Case Reports
Congenital long QT syndrome (LQTS) is a genetic disorder causing prolonged QT intervals and an increased risk of arrhythmias and sudden cardiac death. With 25% of cases lacking known genetic mutations, diagnosis and treatment can be challenging.
Clement Tan, Vaikunthan Thanabalasingam, Chaminda Sella Kapu, Zhihua Zhang   +3 more
doaj   +2 more sources

Genetic variant annotation scores in congenital long QT syndrome [PDF]

Annals of Noninvasive Electrocardiology, 2023
Background Congenital Long QT Syndrome (LQTS) is a hereditary arrhythmic disorder. We aimed to assess the performance of current genetic variant annotation scores among LQTS patients and their predictive impact.
Arwa Younis, Christopher Bodurian, Dan E. Arking, Nicola Luigi Bragazzi, Chadi Tabaja, Wojciech Zareba, Scott McNitt, Mehmet K. Aktas, Bronislava Polonsky, Coeli M. Lopes, Nona Sotoodehnia, Peter J. Kudenchuk, Ilan Goldenberg   +12 more
doaj   +2 more sources

Contribution of continuous intravenous lidocaine in managing congenital long QT syndrome with 2:1 atrioventricular block [PDF]

Indian Pacing and Electrophysiology Journal
Congenital long QT syndrome (LQTS) is a rare hereditary cardiac disorder characterized by prolongation of the QT interval on electrocardiogram (ECG), predisposing affected individuals to life-threatening arrhythmias.
Deebaj Nadeem, Muhammad Mohsin, Faisal Qadir   +2 more
doaj   +2 more sources

Deep Learning-Augmented ECG Analysis for Screening and Genotype Prediction of Congenital Long QT Syndrome.

JAMA Cardiol
Importance Congenital long QT syndrome (LQTS) is associated with syncope, ventricular arrhythmias, and sudden death. Half of patients with LQTS have a normal or borderline-normal QT interval despite LQTS often being detected by QT prolongation on resting
Jiang R, Cheung CC, Garcia-Montero M, Davies B, Cao J, Redfearn D, Laksman ZM, Grondin S, Atallah J, Escudero CA, Cadrin-Tourigny J, Sanatani S, Steinberg C, Joza J, Avram R, Tadros R, Krahn AD.   +16 more
europepmc   +2 more sources

Risk Prediction in Women With Congenital Long QT Syndrome. [PDF]

J Am Heart Assoc, 2021
Background We aimed to provide personalized risk estimates for cardiac events (CEs) and life‐threatening events in women with either type 1 or type 2 long QT.
Goldenberg I, Bos JM, Yoruk A, Chen AY, Lopes C, Huang DT, Kutyifa V, Younis A, Aktas MK, Z Rosero S, McNitt S, Sotoodehnia N, Kudenchuk PJ, Rea TD, Arking DE, Scott CG, Briske KA, Sorensen K, J Ackerman M, Zareba W.   +19 more
europepmc   +2 more sources

Management of patient with acute lymphocytic myocarditis and congenital long QT syndrome presenting with electrical storm and incessant Torsade de Pointes: a case report [PDF]

Journal of Medical Case Reports
Background This case highlights the management of concomitant acute myocarditis and congenital long QT syndrome with electrical storm and incessant Torsade de Pointes.
Giky Karwiky, Raymond Pranata, Alberta Claudia Undarsa, Mohamad Iqbal, Hawani Sasmaya Prameswari, Mohammad Rizki Akbar   +5 more
doaj   +2 more sources