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The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]
, 2012 This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L +5 more
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Congenital Long-QT Syndromes [PDF]
Circulation, 2008 The congenital long-QT syndromes (LQTS) were initially described approximately 50 years ago.1–3 The principal events are syncope, seizures, and ventricular tachycardia, characteristically torsade de pointes. Most often, this arrhythmia is self terminating, producing a syncopal episode; however, LQTS is responsible for a significant proportion of sudden
openaire +1 more source
Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]
, 2000 Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core +1 more source
R-from-T as a common mechanism of arrhythmia initiation in long QT syndromes [PDF]
, 2019 Background: Long QT syndromes (LQTS) arise from many genetic and nongenetic causes with certain characteristic ECG features preceding polymorphic ventricular tachyarrhythmias (PVTs).
Liu, Michael B. +3 more
core +2 more sources
A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y. [PDF]
, 2006 Thousands die each year from sudden infant death syndrome (SIDS). Neither the cause nor basis for varied prevalence in different populations is understood.
Bowers, Peter N +8 more
core +2 more sources
Congenital Long and Short QT Syndromes [PDF]
Cardiology, 2012 Congenital long and short QT syndromes are familial arrhythmias characterized by derangement of repolarization and a high risk of sudden cardiac death due to ventricular tachyarrhythmias. With growing understanding of these syndromes in both the medical and lay communities, diagnostic and therapeutic difficulties are increasingly faced by health care ...
Andrew J, Brenyo +2 more
openaire +2 more sources
Fever-Induced QTc Prolongation and Ventricular Fibrillation in a Healthy Young Man [PDF]
, 2010 Long QT syndrome is associated with lethal tachyarrhythmia that can lead to syncope, seizure, and sudden death. Congenital long QT syndrome is a genetic disorder, characterized by delayed cardiac repolarization and prolongation of the QT interval on the ...
Amin +18 more
core +3 more sources
Congenital and acquired long QT syndrome [PDF]
European Heart Journal, 2000 There is considerable contemporary interest in ventricular repolarization, since prolonged repolarization, especially when heterogeneous, is associated with ventricular tachyarrhythmias, syncope and sudden death. Delayed ventricular repolarization occurs as a congenital anomaly or may be acquired, for example because of the effect of medications on ...
A J, Camm +5 more
openaire +2 more sources
Long QT syndrome - causes and risk factors
Journal of Education, Health and Sport, 2018 Sudden cardiac death is a major public health challenge, which can be caused by genetic or acquired structural or electrophysiological abnormalities. These abnormalities include channelopathies such as long QT, short QT and Brugada syndromes.
Erwin Ciechański +3 more
doaj +3 more sources
Prevalence of the Congenital Long-QT Syndrome [PDF]
Circulation, 2009 Background— The prevalence of genetic arrhythmogenic diseases is unknown. For the long-QT syndrome (LQTS), figures ranging from 1:20 000 to 1:5000 were published, but none was based on actual data. Our objective was to define the prevalence of LQTS.
Schwartz Peter John +15 more
openaire +3 more sources