Results 41 to 50 of about 477,435 (129)

The Initiation and Progression of Neoplasia in Inherited and Sporadic Colorectal Cancer. [PDF]

, 2009
PhDThis dissertation describes investigations into aspects of neoplastic initiation and progression in the gut, in the context of inherited and sporadic gastrointestinal cancer. In familial adenomatous polyposis, there is marked locoregional variation
Will, Olivia Constance Claire
core   +4 more sources

Zebrafish xenograft models as a fast platform for metastasis diagnosis and cisplatin response of head and neck squamous cell carcinoma

Animal Models and Experimental Medicine, EarlyView.
A zebrafish xenograft model accurately distinguishes metastatic from non‐metastatic HNSCC and recapitulates cisplatin sensitivity/resistance patterns. Using patient‐derived tumors, it predicts individual therapeutic responses, offering a rapid, clinically applicable platform for guiding personalized treatment. Abstract Background Head and neck squamous
Lu Chen, Shu Sun, Yujia Liu, Liehao Jiang, Cuiyun Wu, Ting Liu, Yujiao Zhao, Yuwei Liu, Lu Liu, Qi Wang, Xiaowei Zheng, Ping Huang   +11 more
wiley   +1 more source

Rare anorectal malformation with a non-terminal colovesical fistula

Journal of Pediatric Surgery Case Reports, 2015
We describe a unique case of anorectal malformation (ARM) with a non-terminal colovesical fistula. While some aspects are similar to the congenital pouch colon (CPC), the differences make it a distinct form.
Sabine Vasseur Maurer, Eleuthère Stathopoulos, Vanina Estremadoyro, Blaise J. Meyrat   +3 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Disease of South American camelids in England and Wales: Analysis of diagnoses from Animal and Plant Health Agency laboratory submissions between 2012 and 2021

Veterinary Record, EarlyView.
Abstract Background South American camelids (SACs) have become increasingly popular in the UK. Consequently, knowledge among veterinary practitioners about diseases in these non‐native species has improved, although gaps remain. The remit of this study was to identify common diseases of SACs based on Animal and Plant Health Agency (APHA) surveillance ...
Sonja Jeckel, Carissa Xian Chow, David Jorge   +2 more
wiley   +1 more source

Uses of Bovine Pericardium in General Surgery

ANZ Journal of Surgery, EarlyView.
Bovine pericardium is a versatile biologic material with expanding applications across general surgery. ABSTRACT Background Bovine pericardium (BP) is increasingly utilised in complex surgical reconstruction because of its favourable biological and mechanical properties.
William A. Ziaziaris, Makaela Bowman, Paul D. Morris, Kilian G. M. Brown, Michael J. Solomon, Jerome M. Laurence   +5 more
wiley   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, Volume 46, Issue 6, Page 1939-1957, November 2026.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Surgical evaluation of patients presenting with congenital pouch colon: A comprehensive study

National Journal of Physiology, Pharmacy and Pharmacology, 2023
Background: Congenital pouch colon (CPC) is a rare, complex anorectal malformation often associated with various anomalies. Timely diagnosis and recognition of anatomical variations are crucial for effective management.
Aniz A Ratani, Maheshkumar M Vaghela, Jatin Jadhav   +2 more
doaj   +1 more source

Recurrent Congenital Hiatal Hernia After Laparoscopic Repair Complicated by Gastric Perforation and Abdominal Compartment Syndrome

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Complete excision of the hernial sac during congenital hiatal hernia repair may help prevent recurrence. This case also emphasizes the importance of early recognition and prompt management of abdominal compartment syndrome when progressive abdominal distension and organ dysfunction develop postoperatively.
Takayuki Fujii, Yui Noguchi, Nanami Harada, Hiroto Katami, Aya Tanaka   +4 more
wiley   +1 more source

A Terminal Colovesical Fistula in an Anorectal Malformation

Global Pediatric Health, 2020
Anorectal malformations are relatively common anomalies encountered in pediatric surgical practice. They are usually recognized at birth with absent anal canal or failure to pass meconium and hence can lead to life threatening bowel obstruction without ...
Jayalaxmi Shripati Aihole
doaj   +1 more source