Results 51 to 60 of about 23,110 (126)

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, Volume 46, Issue 6, Page 1939-1957, November 2026.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Systemic Bevacizumab for Severe Bleeding From Acquired Gastrointestinal Vascular Malformations

American Journal of Hematology, Volume 101, Issue 10, Page 2605-2615, October 2026.
Targeted antiangiogenic therapy with systemic bevacizumab for bleeding from acquired GI VMs was found to be safe and effective for chronic and severe bleeding from acquired vascular malformations due to idiopathic angiodysplasia, chronic liver disease, and deficiencies of von Willebrand factor, in a patient population comprised mostly of heavily ...
Nardeen E. Ayad, Jacob R. Anderson, Bimalangshu Dey, Rebecca Karp Leaf, Andrew B. Song, Hanny Al‐Samkari   +5 more
wiley   +1 more source

Exclusive enteral nutrition containing transforming growth factor‐β improves intestinal barrier function in a colitis mouse model

Journal of Pediatric Gastroenterology and Nutrition, Volume 83, Issue 4, Page 692-702, October 2026.
Abstract Objectives Exclusive enteral nutrition (EEN) is the first‐line treatment for pediatric Crohn's disease, but its mechanisms of action remain poorly understood. Our aim was to identify the mechanisms that could explain the anti‐inflammatory effects of EEN, studying the nutritional composition and transforming growth factor‐β (TGF‐β) effects, in ...
Kawthar Boumessid, Vickie Lacroix, Ekaterina Ovtchinnikova, Sophie Thenet, Marie Carriere, Frédérick Barreau, Emmanuel Mas   +6 more
wiley   +1 more source

Reevaluating the rule of two's: Age and epidemiological variations in Meckel's diverticulum

Journal of Pediatric Gastroenterology and Nutrition, Volume 83, Issue 4, Page 658-664, October 2026.
Abstract Objective To evaluate the clinical characteristics, diagnostic modalities, and age‐related variation of Meckel's diverticulum (MD) using data from a nationwide pediatric inpatient database and a single‐center institutional cohort. Methods The Kids' Inpatient Database (KID) for 2016 and 2019 was queried for patients with a principal diagnosis ...
Ashley Polachek, Megha S. Mehta, Ahmed Shalaby, Aamirah Vadsariya, Wenjing Zong, David M. Troendle   +5 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Prevalence of Breastfeeding in Infants With Down Syndrome: A Systematic Review and Meta‐Analysis

Acta Paediatrica, Volume 115, Issue 10, Page 2063-2077, October 2026.
ABSTRACT Aim To estimate the prevalence of breastfeeding—overall, exclusive, partial and depending on infants' age—in infants with Down syndrome, and to investigate associated factors. Methods A systematic literature search was conducted in Medline, Cochrane Library, Web of Science, Embase, CINAHL and SciELO up to 1 August 2024.
Mélina Balland, Julia Prillard, Irène Loras‐Duclaux, Caroline Giroudon, Amélie Zelmar, Damien Sanlaville, Mikail Nourredine   +6 more
wiley   +1 more source

The clinical application of laparoscopic-assisted suture hook technique in the repair of Morgagni hernia

BMC Surgery
Background Morgagni hernia is a relatively rare type of diaphragmatic hernia, accounting for approximately 3% to 4% of all congenital diaphragmatic hernias.
Jishen Zhang, Defeng Jin, Xianqi Cai, Zhaoqing Cui, Yutao Wei   +4 more
doaj   +1 more source

Síndrome de intestino corto: definición, causas, adaptación intestinal y sobrecrecimiento bacteriano Short bowel syndrome: definition, causes, intestinal adaptation and bacterial overgrowth

Nutrición Hospitalaria, 2007
El síndrome de intestino corto (SIC) es una entidad compleja debida a una pérdida anatómica o funcional de una parte del intestino delgado que ocasiona un cuadro clínico de graves alteraciones metabólicas y nutricionales debidas a la reducción de la ...
M. D. Ballesteros Pomar, A. Vidal Casariego   +1 more
doaj  

Waardenburg–Shah Syndrome: Diagnostic and Surgical Challenges in a Resource-Limited Setting — A Rare Case Report

International Medical Case Reports Journal
Mohamed Nur Ali,1,* Abdisalam Ismail Hassan,2,* Abdisamad Omar Ali,3 Shuayb Moallim Ali Jama,4 Abdisalam Mohamed Sh Abdilahi,1 Ali Abdi Jama,1 Farah Ali Ahmed,1 Fardowsa Hassan Ahmed,1 Fardowso Ali Mohamud,1 Yahye Abshir Nur,5 Yasir ...
Ali MN, Hassan AI, Ali AO, Jama SMA, Sh Abdilahi AM, Jama AA, Ahmed FA, Ahmed FH, Mohamud FA, Nur YA, Ali YK, Ali AA, Bashir AM   +12 more
doaj