Results 51 to 60 of about 9,088,855 (308)

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

A unified optimization approach for the enhancement of Available Transfer Capability and Congestion Management using unified power flow controller [PDF]

Serbian Journal of Electrical Engineering, 2008
This paper proposes a unified optimization model and algorithm for assessing Available Transfer Capability (ATC) and carrying out Congestion Management (CM) in a Deregulated power system handling both pool and bilateral transactions.
Ramasubramanian Jayashree, Khan Abdullah Mohammed   +1 more
doaj   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Nonlinear Quantum Effects Drive Grotthuss Proton Conduction in Structured Electrolytes Based on Deep Eutectic Solvents

Advanced Science, EarlyView.
We demonstrate that the inverse relationship between viscosity and conductivity in structured electrolytes can be circumvented by leveraging their hydrogen bonding networks for Grotthuss proton transport. Using a mixture of imidazole and levulinic acid, we show that the existence of extended hydrogen‐bonded chains that can rapidly reorient result in ...
Benworth B. Hansen, Michael S. Chen, Giselle de A. L. e Souza, Kaylie Glynn, Alan Robledo, Emilia Pelegano‐Titmuss, Katherine Hightower, Miguel Muñoz, Rathiesh Pandian, Clemens Burda, Aikaterini Sanida, Mark Dadmun, Burcu E. Gurkan, Steve G. Greenbaum, Mark E. Tuckerman, Joshua R. Sangoro   +15 more
wiley   +1 more source

DFLEX: A Blockchain-Anchored Marketplace for Direct Participation of Small Distributed Energy Resources in Transmission and Distribution System Operator Flexibility Markets—Evidence from a One-Year Island Pilot

Energies
Distributed energy resources (DERs), such as prosumers and controllable loads, represent a large and underused reserve of power-system flexibility.
Athanasios S. Dagoumas, Vasileios Laitsos, Despoina I. Makrygiorgou, Dimitra Makrygiorgou, Filippos Rigas, Nikolaos Koltsaklis, Spyridon Roukanas   +6 more
doaj   +1 more source

Principles for Internet Congestion Management

Proceedings of the ACM SIGCOMM 2024 Conference
ACM SIGCOMM '24: Proceedings of the ACM SIGCOMM 2024 ...
Lloyd Brown, Albert Gran Alcoz, Frank Cangialosi, Akshay Narayan 0001, Mohammad Alizadeh, Hari Balakrishnan, Eric J. Friedman, Ethan Katz-Bassett, Arvind Krishnamurthy, Michael Schapira, Scott Shenker   +10 more
openaire   +5 more sources

Managing traffic congestion [PDF]

, 2013
The economic costs of congestion are significant and rising. While the state each year invests in initiatives to relieve congestion, it currently does so in the absence of a statewide plan with clearly defined objectives, strategies and associated agency

core  

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Flow-Tracing-Based Allocation of Congestion-Related Settlement Imbalances in Regional Electricity Markets with Priority-Based Implicit Transmission Rights

Energies
In transitional electricity markets that operate without explicit financial or physical transmission rights but retain priority generation schedules and rigidly executed medium- and long-term (MLT) contracts, network congestion gives rise to settlement ...
Zhaoxia Jing, Wenxiao Li, Xiaodong Chen
doaj   +1 more source