Results 81 to 90 of about 95,729 (308)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

open access: yesAdvanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei   +11 more
wiley   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

open access: yesAdvanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi   +8 more
wiley   +1 more source

gap-packages/congruence: Congruence 1.2.6

open access: yes
<p>Release for Congruence</p ...
Joachim Zobel   +3 more
core   +1 more source

Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China

open access: yesAdvanced Science, EarlyView.
This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang   +3 more
wiley   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun   +27 more
wiley   +1 more source

Varieties satisfying the triangular scheme need not be congruence distributive [PDF]

open access: yes, 2007
summary:A diagrammatic scheme characterizing congruence distributivity of congruence permutable algebras was introduced by the first author in 2001. It is known under the name Triangular Scheme.
Chajda, Ivan, Halaš, Radomír
core  

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

open access: yesAdvanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth   +10 more
wiley   +1 more source

Comment porter le masque vertueux d’une pensée dominante et enseigner la création de liens empreints d’authenticité en relation d’aide ?

open access: yesRevue Internationale Animation, Territoires et Pratiques Socioculturelles
Depuis quelques années, on observe dans les sociétés occidentales le rétrécissement de la liberté d’expression découlant des mesures sanitaires et des discours bienveillants tenus par les universités.
Gregory Ardiet
doaj   +1 more source

A Special Congruence [PDF]

open access: yesProceedings of the American Mathematical Society, 1953
Sei \(p\) eine Primzahl \(>3\), \(m=p^rm_0\), \(r\geq 0\), \(m_0> 0\), ganz , \(w_p=[(p-1)!+1]/p\), \(\delta_m=1\) für \((p-1)\mid[m-1)\), sonst \(\delta_m=0\). Verf.
openaire   +2 more sources

Dynamic Regulation of Supramolecular Chirality in an Amphiphilic Dimeric Macrocycle Through Azobenzene‐Based Photoisomerization

open access: yesAdvanced Science, EarlyView.
A stimuli‐responsive supramolecular system has been rationally designed enabling hierarchical control over supramolecular handedness. This hybrid architecture retains orthogonal host‐guest properties and displays unique amphiphilicity‐directed chiral self‐assembly.
Minzan Zuo   +8 more
wiley   +1 more source

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