Results 21 to 30 of about 2,881 (262)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Electromagnetic conic sections [PDF]
American Journal of Physics, 2002 Certain orthogonal coordinate systems naturally correspond to basis vectors which are both curl-free and divergence-free, and hence solve Maxwell’s equations. After first comparing several different traditional approaches to computing div, grad, and curl in curvilinear coordinates, we present a new approach, based on these “electromagnetic” basis ...
Tevian Dray, Corinne A. Manogue
openaire +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
FERTILIZER METERING MECHANISM WITH HELICAL CONIC CYLINDRICAL THREAD FOR FAMILY AGRICULTURE [PDF]
Engenharia Agrícola, 2018 Small rural farms are important for Brazilian agribusiness, but equipment suitable for distributing fertilizers on these properties is scarce. We studied a new fertilizer metering mechanism for use on the family farm.
Cezario B. Galvão +3 more
doaj +1 more source
Micro Aspheric Convex Lenses Fabricated by Precise Scraping
Micromachines, 2022 An easy, fast, inexpensive, and simple method utilizing a microshaper with a very small knife nose is used to fabricate microconvex aspherical lenses. The microshaper is mounted on a computer numerical control (CNC) machine.
Meng-Ju Lin
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Analysis of Students’ Mathematical Representation Ability in Working on Conical Section Problems
Edumatica: Jurnal Pendidikan MatematikaThis study aims to analyze students’ representational ability in working on conic section problems. This study is included in case study research using a qualitative approach. The subjects of this study were students of Widya Dharma University.
Muhammad Ridlo Yuwono +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Conic Section Elements Based on the Rational Absolute Nodal Coordinate Formulation
MathematicsThe construction of rational absolute nodal coordinate formulation (RANCF) elements is usually based on a linear transformation of non-uniform rational B-spline (NURBS) geometry.
Yaxiong Liu +3 more
doaj +1 more source