Results 31 to 40 of about 59,062 (321)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Electromagnetic conic sections [PDF]

open access: yesAmerican Journal of Physics, 2002
Certain orthogonal coordinate systems naturally correspond to basis vectors which are both curl-free and divergence-free, and hence solve Maxwell’s equations. After first comparing several different traditional approaches to computing div, grad, and curl in curvilinear coordinates, we present a new approach, based on these “electromagnetic” basis ...
Tevian Dray, Corinne A. Manogue
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

FERTILIZER METERING MECHANISM WITH HELICAL CONIC CYLINDRICAL THREAD FOR FAMILY AGRICULTURE [PDF]

open access: yesEngenharia Agrícola, 2018
Small rural farms are important for Brazilian agribusiness, but equipment suitable for distributing fertilizers on these properties is scarce. We studied a new fertilizer metering mechanism for use on the family farm.
Cezario B. Galvão   +3 more
doaj   +1 more source

Micro Aspheric Convex Lenses Fabricated by Precise Scraping

open access: yesMicromachines, 2022
An easy, fast, inexpensive, and simple method utilizing a microshaper with a very small knife nose is used to fabricate microconvex aspherical lenses. The microshaper is mounted on a computer numerical control (CNC) machine.
Meng-Ju Lin
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Analysis of Students’ Mathematical Representation Ability in Working on Conical Section Problems

open access: yesEdumatica: Jurnal Pendidikan Matematika
This study aims to analyze students’ representational ability in working on conic section problems. This study is included in case study research using a qualitative approach. The subjects of this study were students of Widya Dharma University.
Muhammad Ridlo Yuwono   +2 more
doaj   +1 more source

CSD: Discriminance with Conic Section for Improving Reverse k Nearest Neighbors Queries

open access: yes, 2020
The reverse $k$ nearest neighbor (R$k$NN) query finds all points that have the query point as one of their $k$ nearest neighbors ($k$NN), where the $k$NN query finds the $k$ closest points to its query point. Based on the characteristics of conic section,
Bai, Mingyuan   +5 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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