Results 161 to 170 of about 345,370 (259)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Enhancing anandamide signalling through fatty acid amide hydrolase inhibition: An update on the pharmacological strategy for treating psychiatric disorders. [PDF]

Transl Psychiatry
Couttas TA, Hoffmann AE, Jieu B, Golla FR, Shepherd CE, Leweke FM, Rohleder C.   +6 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Ancient DNA as a temporal lens: reconstructing evolution, migration, and disease dynamics. [PDF]

J Genet Eng Biotechnol
Akwo AU, Luvanga J, Ketu KV.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Looking for keys in model organisms: interpreting and keying-up in basal cognition. [PDF]

Hist Philos Life Sci
Rorot W.
europepmc   +1 more source

Magnifying the first points of life: Harvey and Descartes on generation and scale. [PDF]

Hist Sci, 2022
Basse Eriksen C.
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A refined phylochronology of the second plague pandemic in Western Eurasia. [PDF]

Proc Natl Acad Sci U S A
Keller M, Guellil M, Slavin P, Saag L, Irdt K, Kabral H, Solnik A, Malve M, Valk H, Kriiska A, Cessford C, Inskip SA, Robb JE, Cooper C, von Planta C, Seifert M, Reitmaier T, Baetsen WA, Walker D, Lösch S, Szidat S, Metspalu M, Kivisild T, Tambets K, Scheib CL.   +24 more
europepmc   +1 more source

Outdoor Physical Activity During the First Wave of the COVID-19 Pandemic. A Comparative Analysis of Government Restrictions in Italy, France, and Germany. [PDF]

Front Public Health, 2021
Michelini E, Bortoletto N, Porrovecchio A.   +2 more
europepmc   +1 more source