Results 91 to 100 of about 127,892 (269)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Kimmerle conjecture for the Held and O'Nan sporadic simple groups
, 2009 Using the Luthar--Passi method, we investigate the Zassenhaus and Kimmerle conjectures for normalized unit groups of integral group rings of the Held and O'Nan sporadic simple groups.
Bódi, Viktor +2 more
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
On The Sensitivity Conjecture.
Electron. Colloquium Comput. Complex., 2016 The sensitivity of a Boolean function f:{0,1}^n -> {0,1} is the maximal number of neighbors a point in the Boolean hypercube has with different f-value. Roughly speaking, the block sensitivity allows to flip a set of bits (called a block) rather than just one bit, in order to change the value of f. The sensitivity conjecture, posed by Nisan and Szegedy
openaire +4 more sources
Journal of Combinatorial Theory, Series A, 1983 AbstractThe twelve point Desmic configuration in Euclidean three space is composed of three finite sets with the property that any line intersecting points of two of the sets also intersects the remaining set. The Desmic conjecture asserts that this is the only such configuration. In this paper the Desmic conjecture is proven.
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Journal of Combinatorial Theory, Series B, 1985 The authors prove the following conjecture of Bondy: if G is a k- connected graph, where \(k\geq 2\), such that the degree-sum of any \(k+1\) independent vertices is at least m, then G contains a cycle of length at least \(\min (2m/(k+1),n)\) (n denotes the order of G).
Irène Fournier, Pierre Fraisse
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FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Bredon homology and equivariant K-homology of SL(3,Z)
, 2008 We obtain the equivariant K-homology of the classifying space underline{E}SL(3,Z) from the computation of its Bredon homology with respect to finite subgroups and coefficients in the representation ring.
Sanchez-Garcia, Ruben
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source