Results 81 to 90 of about 127,892 (269)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Discrete Mathematics, 1989 B. Alspach asked the following question. If n is odd (even) and \(a_ 1+a_ 2+...+a_ m=n(n-1)/2,\) \((n(n-2)/2),\) \(3\leq a_ i\leq n,\) can be edges of \(K_ n\) \((K_ n-F\), F is a 1-factor) be partitioned into m cycles \(C_{a_ 1},C_{a_ 2},...,C_{a_ m}?\) The present paper gives an affirmative answer to this question in cases (i) \(a_ i\in \{n-2,n-1,n\}\
Katherine Heinrich +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Transactions of the American Mathematical Society, 1972 Knaster's conjecture is: given a continuous g: Sn Em and a set A of n-rm + 2 distinct points (q 1,. qn m+2) in Sn there exists a rotation r: Sn + Sn such that g(r(q 1)) = g(r(q2))= g(r(qnm + 2.)) We prove a stronger statement about a smaller class of functions.
openaire +2 more sources
On a Conjecture of Helleseth [PDF]
, 2013 We are concern about a conjecture proposed in the middle of the seventies by Hellesseth in the framework of maximal sequences and theirs cross-correlations. The conjecture claims the existence of a zero outphase Fourier coefficient. We give some divisibility properties in this direction.
Yves Aubry, Philippe Langevin
openaire +2 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Journal of Symbolic Logic, 1994 The Genericity Conjecture, as stated in Beller-Jensen-Welch [1], is the following:(*) If O# ∉ L[R], R ⊆ ω, then R is generic over L.We must be precise about what is meant by “generic”.Definition (Stated in Class Theory). A generic extension of an inner model M is an inner model M[G] such that for some forcing notion ⊆ M:(a) 〈M, 〉 is amenable and ⊩ is 〈
openaire +2 more sources
Behind and beyond a theorem on groups related to trivalent graphs
, 2008 In 2006 we completed the proof of a five-part conjecture that was made in 1977 about a family of groups related to trivalent graphs. This family covers all 2-generator, 2-relator groups where one relator specifies that a generator is an involution and ...
DALE C. SUTHERLAND +5 more
core +1 more source