Results 161 to 170 of about 404,179 (310)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Estimating the unemployment rate using least square and conjugate gradient methods

, 2018
Unemployment rate is one of the major issues among Malaysian citizens. The unemployment rate indicates the percentage of the total workforce who are actively seeking employment and currently unemployed.
Nur Hamizah Abdul Ghani, Norhaslinda Zull, Mohd Rivaie, Syazni Syoid, Mustafa Mamat, Nur Syarafina Mohamed, (UniKL MITEC)   +6 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Substituent Effects of Heptamethine Cyanine Dyes on Drug Uptake in Patient-Derived Glioma Cells. [PDF]

ChemMedChem
Dumo CJ, Choi PJ, Liu Y, Muhammad O, Correia JA, Dragunow M, Park TI, Jose J.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Microwave-Assisted Thioester-Empowered Toolkit for Modular Glycopeptide Synthesis

JACS Au
Yue Yang, Miaomiao Zhang, Meng-Hai Xiang, Tong Li, Huiran Hao, Yuanyuan Li, Ning Wang, Richard R. Schmidt, Hongxiang Lou, Peng Peng, Tianlu Li   +10 more
doaj   +1 more source

Development and Characterization of the PSMA-Expressing CT26-PSMA Cell Line as a Rapid Preclinical Platform for ⁶⁸Ga-Labeled PSMA-Targeted Radioconjugates. [PDF]

Int J Mol Sci
Lunev AS, Petrosova KA, Rakhimov MG, Uspenskaia AA, Machulkin AE, Malakhov IS, Shashkova OA, Samoilovich MP, Zakharkina AE, Larenkov AA.   +9 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A poly(3-hydroxybutyrate)-chitosan polymer conjugate for the synthesis of safer gold nanoparticles and their applications

A facile and eco-friendly approach is developed for the synthesis of a poly(3-hydroxybutyrate)–chitosan (PHB–chit) polymer conjugate, which is an ideal material for the synthesis of safer gold nanoparticles (nAu).
Waclawek Stanislaw Witold, Torres Mendieta Rafael Omar, Nguyen Nhung Anh Huynh, Müllerová Jana, Stuchlík Martin, Silvestri Daniele, Černík Miroslav, Sobel Bartłomiej, Varma Rajendra, Vellora Thekkae Padil Vinod, Ševců Alena, Petrangeli Papini Marco, Novotný Vít   +12 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source