Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose A new workflow was investigated for Elekta Unity MR‐Linac by removing the computed tomography (CT)‐simulation step and using diagnostic CT (DCT) for reference plan generation. Materials and methods Ten patients with ultra‐hypofractionated prostate cancer treated with magnetic resonance imaging (MRI)‐guided adaptive radiotherapy were ...
Yuan Xu +5 more
wiley +1 more source
Formation of mono- and dual-labelled antibody fragment conjugates via reversible site-selective disulfide modification and proximity induced lysine reactivity. [PDF]
Chem SciThanasi IA +10 more
europepmc +1 more source
Log file‐based quality assurance method for respiratory gating system
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Background As medical linear accelerator technology advances, enabling higher dose rate deliveries, hypofractionation regimens has increased. This necessitates respiratory gating systems that synchronize radiation delivery with tumor position, requiring simple rigorous quality assurance (QA) to ensure treatment accuracy and patient safety ...
Wonjoong Cheon +7 more
wiley +1 more source
Enhancement of Physicochemical and Functional Properties of Chicken Breast Protein Through Polyphenol Conjugation: A Novel Ingredient for Protein Supplements. [PDF]
MoleculesSon WY +6 more
europepmc +1 more source
Machine stability and dosimetry for ultra‐high dose rate FLASH radiotherapy human clinical protocol
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Background The FLASH effect, induced by ultra‐high dose rate (UHDR) irradiations, offers the potential to spare normal tissue while effectively treating tumors. It is important to achieve precise and accurate dose delivery and to establish reliable detector systems, particularly for clinical trials needed to help the clinical transfer of FLASH‐
Patrik Gonçalves Jorge +9 more
wiley +1 more source
Towards precision medicine using biochemically triggered cleavable conjugation. [PDF]
Commun ChemParshad B +6 more
europepmc +1 more source
Heterozygous variants in AP4S1 are not associated with a neurological phenotype
Annals of Clinical and Translational Neurology, EarlyView.Abstract Biallelic loss‐of‐function variants in AP4S1 cause childhood‐onset hereditary spastic paraplegia. A recent report suggested that heterozygous AP4S1 variants lead to a syndrome of lower limb spasticity and dysregulation of sphincter function. We critically evaluate this claim against clinical observations in 28 heterozygous carriers of the same
Vicente Quiroz +9 more
wiley +1 more source
Global distribution and characteristics of pneumococcal serotypes in adults. [PDF]
Hum Vaccin ImmunotherMaeda H, Morimoto K.
europepmc +1 more source
ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective We performed a pilot screen to assess the utility of the NULISA™ (Nucleic‐acid‐Linked Immuno‐Sandwich Assay) platform in the identification of amyotrophic lateral sclerosis (ALS) biomarkers. Methods Plasma from 86 individuals (48 ALS, 18 asymptomatic C9orf72 repeat expansion carriers (AsymC9), and 20 healthy controls) was analyzed ...
Eleanor V. Thomas +10 more
wiley +1 more source
PCV13-Serotype Breakthrough Pneumococcal Disease in Infants Receiving High-Valency Conjugate Vaccines: Population-Level Modeling in France. [PDF]
Infect Dis TherBakker KM +7 more
europepmc +1 more source